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Front Matter (i-xiv)

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Introduction (1-4)

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1 Regulatory and Ethical Considerations (5-11)

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2 Protocol-Development Strategies (12-29)

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3 General Animal-Care Concerns (30-68)

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4 Survival Studies (69-87)

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5 Prolonged Nonsurvival Studies (88-93)

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6 Studies of Neural Injury and Disease (94-101)

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7 Perinatal Studies (102-108)

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8 Agents and Treatments (109-122)

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9 Behavioral Studies (123-149)

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References (150-174)

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Appendix A: Sample Size Determination (175-180)

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Appendix B: Estimating Animal Numbers (181-190)

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Appendix C: Biographical Sketches of Authoring Committee (191-194)

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Index (195-209)

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