53 matches found for How People Learn Brain,Mind,Experience,and School Expanded Edition. in 1 Introduction and Background
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... Introduction and Background1...
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... Accumulating evidence gathered over the past three decades has demonstrated a biological basis for differences between men and women with respect to clinical features and treatment responses to several neuropsychiatric, neurodevelopmental, and neurodegenerative disorders. ... also been identified in the brain transcriptomes of individuals with multiple brain disorders, including depression, posttraumatic stress disorder, and autism. The brain transcriptome includes all of the messenger RNA as well as the non-protein-coding RNA molecules expressed in brain tissue and thus ... gene activity. To explore these sex-based transcriptomic differences further, the National Academies of Sciences, Engineering, and Medicine’s (the National Academies’) Forum on Neuroscience and Nervous System Disorders (Neuroscience Forum) hosted a workshop on September 23, ... , titled Sex Differences in Brain Disorders: Emerging Transcriptomic Evidence and Implications for Therapeutic Development. The workshop brought together a broad spectrum of stakeholders to share cutting-edge emerging evidence, ... challenges, and identify future opportunities and potential directions....
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... This workshop explored the evolving understanding of sex differences in brain disorders, as reflected in previous reports and workshops convened...
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... 1 The planning committee’s role was limited to planning the workshop, and the Proceedings of a Workshop was prepared by the workshop rapporteurs as a factual summary of what occurred at the workshop. Statements, ... , and opinions expressed are those of individual presenters and participants, and have not been endorsed or verified by the National Academies of Sciences, Engineering, and Medicine. They should not be construed as reflecting any ...
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... sex matters in explorations of the biological contributions to human health. In that report, Mary-Lou Pardue, chair of the IOM Committee on Understanding the Biology of Sex and Gender Differences answered, “Sex does matter. It matters in ways that we did not expect. Undoubtedly, it also matters in ...
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... Ten years after that report, the Neuroscience Forum hosted a workshop on Sex Differences and Implications for Translational Neuroscience Research (IOM, 2011). By then, understanding of sex differences at the biological level had advanced ... at the National Institutes of Health (NIH), noted that sex-specific research had been stymied by a limited focus on clinical studies. Molecular- and cellular-level research, she said, was essential to understanding sex differences in health....
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... Now, 10 years after the 2010 workshop and 20 years after the 2000 IOM report, recent advances in developing tools and technologies for molecular- and cellular-level research have fueled further advances and investigators are vigorously pursuing this research, said Rita Valentino, director of the ... of Neuroscience and Behavior at the National Institute on Drug Abuse....
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... all NIH-funded research consider sex as a biological variable, said workshop chair Eric Nestler, Nash Family Professor of Neuroscience at the Icahn School of Medicine at Mount Sinai. Nestler called this mandate “transformational.” For many years, his lab, like many others, had studied male rodents ...
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... The workshop was designed to explore emerging data about sex differences in the underlying biology of many different brain disorders with...
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... a focus on transcriptomic evidence; to consider how this evidence may advance understanding of brain disorder pathophysiology; to examine potential opportunities for applying this knowledge in the development of improved sex-specific ... ; and to review obstacles that must be overcome to realize this potential (see Box 1-1). Nestler noted that studying the impact of sex in a binary way— ... and female—excludes people who do not fall along the male/female binary, for example, transgender individuals, those who have transitioned sex, and intersex individuals. Although this area of research is extremely important, he said, it is difficult to study in animal models, and the lack of ...
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... Research presented at the workshop by individual participants is not a systematic review of the scientific landscape, but rather examples of emerging transcriptomic evidence for sex differences in brain disorders. Due to time restrictions, this 1-day workshop ...
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... This public workshop will bring together experts and key stakeholders from academia, government, industry, and nonprofit organizations to explore emerging evidence regarding differences in transcriptomic abnormalities that occur in the brains of men versus ... with a variety of brain disorders including depression, posttraumatic stress disorder, drug addiction, neurodegenerative conditions, and other brain disorders....
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... Invited presentations and discussions will be designed to:...
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... Review the landscape of emerging evidence regarding sex differences in transcriptomic abnormalities in a variety of brain disorders and discuss how this can be used to advance understanding of brain disorder pathophysiology....
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... Explore ramifications for therapeutic development for these disorders, including identification of new targets, implications for preclinical and clinical study design, regulatory considerations, and potential sex-specific treatments....
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... Discuss open research questions and opportunities to move the field forward....
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... The committee will develop the agenda for the workshop, select and invite speakers and discussants, and moderate the discussions. A proceedings of the presentations and discussions at the workshop will be prepared by a designated rapporteur in ...
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... differences in health and disease, or the merits and limitations of comparative studies apart from those in humans and mice, due to time restrictions....
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... The workshop was organized around several psychiatric and neurological disorders with evidence of biological differences according to sex. Chapter 2 focuses on stress- and reward-related disorders; Chapter 3 ... neurodevelopmental and neurodegenerative disorders. Chapter 4 transitions to a focus on policy implications and how federal agencies, industry, and nonprofit organizations can partner to leverage this new biology of sex differences to improve diagnostics and therapeutics for a range of brain ...
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