Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals contains a detailed and comprehensive methodology for developing acute exposure guideline levels (AEGLs) for toxic substances from inhalation exposures.
The book provides guidance on what documents and databases to use, toxicity endpoints that need to be evaluated, dosimetry corrections from animal to human exposures, selection of appropriate uncertainty factors to address the variability between animals and humans and within the human population, selection of modifying factors to address data deficiencies, time scaling, and quantitative cancer risk assessment.
It also contains an example of a summary of a technical support document and an example of AEGL derivation. This book will be useful to persons in the derivation of levels from other exposure routes—both oral and dermal—as well as risk assessors in the government, academe, and private industry.
National Research Council. 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals. Washington, DC: The National Academies Press. https://doi.org/10.17226/10122.
|Roster of the National Advisory Committee for Acute Exposure Guideline Levels (NAC/AEGL Committee) for Hazardous Substances||7-14|
|Appendix: Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals||15-16|
|1 Overview of AEGL Program and NAC/AEGL Committee||19-33|
|2 Derivation of AEGL Values||34-123|
|3 Format and Content of Technical Support Documents||124-138|
|4 Current Administrative Processes and Procedures for the Development of AEGL Values||139-153|
|A Priority Lists of Chemicals||165-172|
|B Diagram of the AEGL Development Process||173-174|
|C Glossary of Acronyms, Abbreviations, and Symbols||175-178|
|D Example of a Table of Contents of a Technical Support Document||179-181|
|E Example of a Summary of a Technical Support Document||182-185|
|F Example of the Derivation of AEGL Values Appendix in a Technical Support Document||186-189|
|G Example of Time-Scaling Calculations Appendix in a Technical Support Document||190-193|
|H Example of a Carcinogenicity Assessment Appendix in a Technical Support Document||194-195|
|I Example of the AEGL Derivation Summary Appendix in a Technical Support Document||196-200|
|J List of Extant Standards and Guidelines in a Technical Support Document||201-202|
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