By two years of age, healthy infants in the United States can receive up to 20 vaccinations to protect against 11 diseases. Although most people know that vaccines effectively protect against serious infectious diseases, approximately one-quarter of parents in a recent survey believe that infants get more vaccines than are good for them, and that too many immunizations could overwhelm an infant's immune system. The Immunization Safety Review Committee reviewed the evidence regarding the hypothesis that multiple immunizations increase the risk for immune dysfunction. Specifically, the committee looked at evidence of potential biological mechanisms and at epidemiological evidence for or against causality related to risk for infections, the autoimmune disease type 1 diabetes, and allergic disorders.
Institute of Medicine. 2002. Immunization Safety Review: Multiple Immunizations and Immune Dysfunction. Washington, DC: The National Academies Press. https://doi.org/10.17226/10306.
|Immunization Safety Review: Multiple Immunizations and Immune Dysfunction||23-126|
|Appendix A Chronology of Important Events Regarding Vaccine Safety||127-130|
|Appendix B Committee Conclusions and Recommendations from Previous Reports||131-134|
|Appendix C Immmunization Safety Review Committee||135-136|
|Appendix D Methods of Identifying the Literature for the Causality Agreement||137-138|
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