Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment

National Research Council

doi:10.17226/11688

Consensus Study Report

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Health Risks from Dioxin and Related Compounds

Evaluation of the EPA Reassessment

(2006)

Although the U.S. Environmental Protection Agency presented a comprehensive review of the scientific literature in its 2003 draft reassessment of the risks of dioxin, the agency did not sufficiently quantify the uncertainties and variabilities associated with the risks, nor did it adequately justify the assumptions used to estimate them, according to this new report from the National Academies' National Research Council. The committee that wrote the report recommended that EPA re-estimate the risks using several different assumptions and better communicate the uncertainties in those estimates. The agency also should explain more clearly how it selects both the data upon which the reassessment is based and the methods used to analyze them.

Contributor(s): National Research Council; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Committee on EPA's Exposure and Human Health Reassessment of TCDD and Related Compounds

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Suggested Citation

National Research Council. 2006. Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment. Washington, DC: The National Academies Press. https://doi.org/10.17226/11688.

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Publication Info

268 pages | 6 x 9 |

ISBNs:

Paperback: 978-0-309-10258-2
Ebook: 978-0-309-13388-3

DOI: https://doi.org/10.17226/11688

Chapters		skim
Front Matter	i-xxviii
Public Summary	1-10
Summary	11-27
1 Introduction	28-44
2 General Considerations of Uncertaintyand Variability, Selection of DoseMetric, and Dose-Response Modeling	45-74
3 Toxic Equivalency Factors	75-89
4 Exposure Assessment	90-107
5 Cancer	108-143
6 Noncancer End Points	144-174
7 Review of Risk Characterization	175-187
8 Conclusions and Recommendations	188-198
References	199-226
A Biographical Information onCommittee Members	227-235
B EPA's 2005 Guidelines forCarcinogen Risk Assessment	236-240

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