Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

National Research Council

doi:10.17226/12037

Consensus Study Report

VIEW LARGER COVER

Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment

(2007)

The new field of toxicogenomics presents a potentially powerful set of tools to better understand the health effects of exposures to toxicants in the environment. At the request of the National Institute of Environmental Health Sciences, the National Research Council assembled a committee to identify the benefits of toxicogenomics, the challenges to achieving them, and potential approaches to overcoming such challenges. The report concludes that realizing the potential of toxicogenomics to improve public health decisions will require a concerted effort to generate data, make use of existing data, and study data in new ways—an effort requiring funding, interagency coordination, and data management strategies.

Contributor(s): National Research Council; Division on Earth and Life Studies; Board on Environmental Studies and Toxicology; Board on Life Sciences; Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology

RESOURCES AT A GLANCE

Topics

Suggested Citation

National Research Council. 2007. Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment. Washington, DC: The National Academies Press. https://doi.org/10.17226/12037.

Import this citation to:

Publication Info

300 pages | 6 x 9 |

ISBNs:

Paperback: 978-0-309-11298-7
Ebook: 978-0-309-17889-1

DOI: https://doi.org/10.17226/12037

Chapters		skim
Front Matter	i-xxiv
Summary	1-10
1 Introduction	11-21
2 Toxicogenomic Technologies	22-44
3 Experimental Design and Data Analysis	45-58
4 Application to Exposure Assessment	59-72
5 Application to Hazard Screening	73-91
6 Application to Analyzing Variation in Human Susceptibility	92-106
7 Application to the Study of Mechanisms of Action	107-120
8 Other Potential Applications of Toxicogenomic Technologies to Risk Assessment	121-134
9 Validation	135-151
10 Sample and Data Collection and Analysis	152-171
11 Ethical, Legal, and Social Issues	172-200
12 Conclusions and Recommendations	201-212
References	213-254
Appendix A: Biographic Information on the Committee on Applications of Toxicogenomic Technologies to Predictive Toxicology	255-261
Appendix B: Minimum Information About a Microarray Experiment for Toxicogenomics	262-269
Appendix C: Overview of Risk Assessment	270-276

What is skim?

The Chapter Skim search tool presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter. You may select key terms to highlight them within pages of each chapter.

Copyright Information

The National Academies Press (NAP) has partnered with Copyright Clearance Center's Rightslink service to offer you a variety of options for reusing NAP content. Through Rightslink, you may request permission to reprint NAP content in another publication, course pack, secure website, or other media. Rightslink allows you to instantly obtain permission, pay related fees, and print a license directly from the NAP website. The complete terms and conditions of your reuse license can be found in the license agreement that will be made available to you during the online order process. To request permission through Rightslink you are required to create an account by filling out a simple online form. The following list describes license reuses offered by the National Academies Press (NAP) through Rightslink:

Republish text, tables, figures, or images in print
Post on a secure Intranet/Extranet website
Use in a PowerPoint Presentation
Distribute via CD-ROM
Photocopy

Click here to obtain permission for the above reuses. If you have questions or comments concerning the Rightslink service, please contact:

Rightslink Customer Care
Tel (toll free): 877/622-5543
Tel: 978/777-9929
E-mail: customercare@copyright.com
Web: http://www.rightslink.com

To request permission to distribute a PDF, please contact our Customer Service Department at 800-624-6242 for pricing.

To request permission to translate a book published by the National Academies Press or its imprint, the Joseph Henry Press, pleaseclick here to view more information.

Loading stats for Applications of Toxicogenomic Technologies to Predictive Toxicology and Risk Assessment...