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This book results from a study by a committee of the Institute of Medicine and the National Research Council's Board on Agriculture. The committee examined the scientific foundations of medically assisted conception and developed an agenda for basic research in reproductive and developmental biology that would contribute to advances in the clinical and agricultural practice of in vitro fertilization and embryo transfer. The volume also discusses some barriers to progress in research and ways of lowering them, and explains the scientific issues important to ethical decision making.

Suggested Citation

Institute of Medicine. 1989. Medically Assisted Conception: An Agenda for Research. Washington, DC: The National Academies Press.

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Publication Info

370 pages |  6 x 9 |  Paperback
ISBN: 978-0-309-04128-7
Chapters skim
Front Matter i-viii
Summary/Scope of the Study 1-14
I. In Vitro Fertilization and Embryo Transfer and Social Concerns 15-24
II. Advances in the Practive and Science Base of Medically Assisted Conception 25-65
III. Barriers to Progress in In Vitro Fertilization and Embryo Transfer 66-85
IV. Research Agenda and Recommendations 86-94
Appendix A: Papers Presented at Workshop 95-95
Technologies for Assisted Conception/Embryo Transfer in Agricultural and Veterinary Practice 96-116
Ovarian Stimulation in Non-Human Primates 117-129
Responses to Gonadotropins in Domestic Animals 130-154
Membrane Models: Evolution From the Fluid-Mosaic Standby 155-175
Mammalian Oocyte Maturation: Mechanisms for Regulation and Prospects for Practical Application of In Vitro Technology 176-190
Intragonadal Control of Testis Function 191-210
Paracrine Regulation in the Ovary 211-233
Experimental Approaches to the Study of Early Developmental Failure in Human Reproduction 234-249
The Fertilizing Sperm: Structure, Maturation and Function 250-261
Molecular Events Pre- and Post-Fertilization of Mouse Eggs: Oocyte Maturation, Egg Activation, and Polyspermy Block 262-281
Glycolytic Pathway in Preimplantation Mammalian Embryos 282-303
Regulative Potential of Micromanipulated Embryos 304-318
Uterine Receptivity, Maternal Recognition of Pregnancy and Early Embryonic Loss 319-335
Towards a Cellular and Molecular Understanding of Implantation in the Human: Implications for Assisted Reproductive Technologies 336-361

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