Folic Acid: Biochemistry and Physiology in Relation to the Human Nutrition Requirement

National Research Council

doi:10.17226/20320

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Suggested Citation

National Research Council. 1977. Folic Acid: Biochemistry and Physiology in Relation to the Human Nutrition Requirement. Washington, DC: The National Academies Press. https://doi.org/10.17226/20320.

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Publication Info

309 pages | 5 x 9 | DOI: https://doi.org/10.17226/20320

Chapters		skim
Front Matter	i-vii
INTRODUCTION	1-2
FOLIC ACID BIOCHEMISTRY: PRESENT STATUS AND FUTURE DIRECTION	3-24
STUDIES ON THE BIOLOGICAL ROLE OF FOLIC ACID POLYGLUTAMATES	25-42
FOLATE POLYGLUTAMYL CHAIN LENGTH OF MAMMALIAN AND BACTERIAL CELLS	43-55
DISTRIBUTION OF FOLATE FORMS IN FOOD AND FOLATE AVAILABILITY	56-68
DATA ON FOLACIN ACTIVITY IN FOODS: AVAILABILITY, APPLICATIONS, AND LIMITATIONS	69-81
USE AND SIGNIFICANCE OF FOLATE BINDERS	82-97
MEASUREMENT OF SERUM FOLATE LEVELS: CURRENT STATUS OF THE RADIOASSAY METHODOLOGY	98-109
FOLATE POLYGLUTAMATE SYNTHESIS AND BREAKDOWN IN HUMAN CELLS	110-121
REGULATION OF FOLATE METABOLISM BY VITAMIN B12	122-135
ROLE OF INTESTINAL CONJUGASE IN THE CONTROL OF THE ABSORPTION OF POLYGLUTAMYL FOLATES	136-146
PLASMA CONJUGASE ACTIVITY IN HEALTH AND DISEASE	147-151
AUTOMATED MICROBIOLOGICAL ASSAY FOR FOLIC ACID	152-155
MECHANISMS IN THE PRODUCTION OF MEGALOBLASTIC ANEMIA	156-168
DRUG-INDUCED FOLATE DEFICIENCY	169-177
MECHANISM OF UPTAKE OF FOLATE MONOGLUTAMATES AND THEIR METABOLISM	178-187
PHYSIOLOGY OF ABSORPTION OF MONOGLUTAMYL FOLATES FROM THE GASTROINTESTINAL TRACT	188-197
PROCESS OF DIGESTION AND ABSORPTION OF PTEROYLPOLYGLUTAMATE	198-208
INTRODUCTION TO DISCUSSION OF HUMAN REQUIREMENTS FOR FOLIC ACID	209-212
DETECTION OF FOLIC ACID DEFICIENCY IN POPULATIONS	213-231
FOLACIN REQUIREMENT OF INFANTS	232-246
FOLIC ACID REQUIREMENT IN ADULTS (INCLUDING PREGNANT AND LACTATING FEMALES)	247-255
FOLIC ACID REQUIREMENT IN SITUATIONS OF INCREASED NEED	256-276
SUMMARY OF THE WORKSHOP	277-294
CONTRIBUTORS	295-296
ATTENDEES	297-300

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