TY - BOOK AU - National Academies of Sciences, Engineering, and Medicine TI - Reproducibility Issues in Research with Animals and Animal Models: Workshop in Brief DO - 10.17226/21835 PY - 2015 UR - https://nap.nationalacademies.org/catalog/21835/reproducibility-issues-in-research-with-animals-and-animal-models-workshop PB - The National Academies Press CY - Washington, DC LA - English KW - Biology and Life Sciences AB - In June 2014, the Roundtable on Science and Welfare in Laboratory Animal Use organized a public workshop to discuss fundamental aspects of experimental design of research using animals and animal models, aimed at improving reproducibility. At this workshop, researchers from around the world explored the many facets of animal-based research that could contribute to irreproducible results, including perspectives on improving experimental planning, design, and execution; the importance of reporting all methodological details; and efforts to establish harmonization principles of reporting on the care and use of animals in research studies. ER - TY - BOOK AU - National Academies of Sciences, Engineering, and Medicine TI - Fostering Integrity in Research SN - DO - 10.17226/21896 PY - 2017 UR - https://nap.nationalacademies.org/catalog/21896/fostering-integrity-in-research PB - The National Academies Press CY - Washington, DC LA - English KW - Policy for Science and Technology AB - The integrity of knowledge that emerges from research is based on individual and collective adherence to core values of objectivity, honesty, openness, fairness, accountability, and stewardship. Integrity in science means that the organizations in which research is conducted encourage those involved to exemplify these values in every step of the research process. Understanding the dynamics that support – or distort – practices that uphold the integrity of research by all participants ensures that the research enterprise advances knowledge. The 1992 report Responsible Science: Ensuring the Integrity of the Research Process evaluated issues related to scientific responsibility and the conduct of research. It provided a valuable service in describing and analyzing a very complicated set of issues, and has served as a crucial basis for thinking about research integrity for more than two decades. However, as experience has accumulated with various forms of research misconduct, detrimental research practices, and other forms of misconduct, as subsequent empirical research has revealed more about the nature of scientific misconduct, and because technological and social changes have altered the environment in which science is conducted, it is clear that the framework established more than two decades ago needs to be updated. Responsible Science served as a valuable benchmark to set the context for this most recent analysis and to help guide the committee's thought process. Fostering Integrity in Research identifies best practices in research and recommends practical options for discouraging and addressing research misconduct and detrimental research practices. ER - TY - BOOK AU - National Academies of Sciences, Engineering, and Medicine TI - Reproducibility and Replicability in Science SN - DO - 10.17226/25303 PY - 2019 UR - https://nap.nationalacademies.org/catalog/25303/reproducibility-and-replicability-in-science PB - The National Academies Press CY - Washington, DC LA - English KW - Surveys and Statistics KW - Policy for Science and Technology AB - One of the pathways by which the scientific community confirms the validity of a new scientific discovery is by repeating the research that produced it. When a scientific effort fails to independently confirm the computations or results of a previous study, some fear that it may be a symptom of a lack of rigor in science, while others argue that such an observed inconsistency can be an important precursor to new discovery. Concerns about reproducibility and replicability have been expressed in both scientific and popular media. As these concerns came to light, Congress requested that the National Academies of Sciences, Engineering, and Medicine conduct a study to assess the extent of issues related to reproducibility and replicability and to offer recommendations for improving rigor and transparency in scientific research. Reproducibility and Replicability in Science defines reproducibility and replicability and examines the factors that may lead to non-reproducibility and non-replicability in research. Unlike the typical expectation of reproducibility between two computations, expectations about replicability are more nuanced, and in some cases a lack of replicability can aid the process of scientific discovery. This report provides recommendations to researchers, academic institutions, journals, and funders on steps they can take to improve reproducibility and replicability in science. ER -