TY - BOOK AU - Institute of Medicine A2 - Kathleen Stratton A2 - Donna A. Almario A2 - Marie C. McCormick TI - Immunization Safety Review: SV40 Contamination of Polio Vaccine and Cancer SN - DO - 10.17226/10534 PY - 2003 UR - https://nap.nationalacademies.org/catalog/10534/immunization-safety-review-sv40-contamination-of-polio-vaccine-and-cancer PB - The National Academies Press CY - Washington, DC LA - English KW - Health and Medicine AB - The Immunization Safety Review Committee was established by the Institute of Medicine (IOM) to evaluate the evidence on possible causal associations between immunizations and certain adverse outcomes, and to then present conclusions and recommendations. The committee's mandate also includes assessing the broader societal significance of these immunization safety issues. While all the committee members share the view that immunization is generally beneficial, none of them has a vested interest in the specific immunization safety issues that come before the group. The committee reviews three immunization safety review topics each year, addressing each one at a time. In this fifth report in a series, the committee examines the hypothesis that exposure to polio vaccine contaminated with simian virus 40 (SV40), a virus that causes inapparent infection in some monkeys, can cause certain types of cancer. ER - TY - BOOK AU - Institute of Medicine A2 - Kathleen Stratton A2 - Donna A. Almario A2 - Theresa M. Wizemann A2 - Marie C. McCormick TI - Immunization Safety Review: Vaccinations and Sudden Unexpected Death in Infancy SN - DO - 10.17226/10649 PY - 2003 UR - https://nap.nationalacademies.org/catalog/10649/immunization-safety-review-vaccinations-and-sudden-unexpected-death-in-infancy PB - The National Academies Press CY - Washington, DC LA - English KW - Health and Medicine AB - With current recommendations calling for infants to receive multiple doses of vaccines during their first year of life and with sudden infant death syndrome (SIDS) the most frequent cause of death during the postneonatal period, it is important to respond to concerns that vaccination might play a role in sudden unexpected infant death. The committee reviewed epidemiologic evidence focusing on three outcomes: SIDS, all SUDI (sudden unexpected death in infancy), and neonatal death (infant death, whether sudden or not, during the first 4 weeks of life). Based on this review, the committee concluded that the evidence favors rejection of a causal relationship between some vaccines and SIDS; and that the evidence is inadequate to accept or reject a causal relationship between other vaccines and SIDS, SUDI, or neonatal death. The evidence regarding biological mechanisms is essentially theoretical, reflecting in large measure the lack of knowledge concerning the pathogenesis of SIDS. ER -