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CONTRACT SUMMARY 10 ⢠Evaluation of TCDD in blood serum samples from selected veterans likely to have been heavily exposed and of an appropriate selection of Vietnam-era veteran controls using high-resolution gas chromatography/high-resolution mass spectrometry analysis. ⢠Examination of the utility of chemical-activated luciferase gene expression (CALUX) analysis as a lower-cost method of screening for TCDD exposure in studies of Vietnam veterans. Project 5: Analysis of International Agency for Research on Cancer (IARC) Tissue Samples of Selected Vietnamese for Dioxin and Dibenzofuran Levels in Archived Adipose Tissues ⢠Evaluation of the correlation between levels of TCDD and dioxin- and dibenzofuran congeners in adipose tissue collected from Vietnamese citizens as part of an IARC case-control study tissue archive with lifetime residence-history data and herbicide-spray records, on the basis of the exposure-opportunity index developed in Project 1. EVOLUTION OF PROJECT DEVELOPMENT AND IMPLEMENTATION In the course of the study, the Columbia University researchers entered considerable amounts of data into new composite databases, creating, cleaning, and expanding archives for use in future epidemiologic studies. They also refined their computational approaches and developed new approaches to classifying and analyzing existing data. The researchers conducted two large surveys to elucidate the extent to which covariates and confounders must be considered in designing and executing studies of the effects of herbicide exposure on Vietnam veterans. In the course of seeking access to military personnel records for research purposes, they documented gaps and flaws in the data and identified potential barriers to conducting new studies of veterans' health.
