National Academies Press: OpenBook
« Previous: Specific Comments
Suggested Citation:"General Comments." National Research Council. 2004. Tenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/10894.
×
Page 14

Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

TENTH INTERIM REPORT OF THE SUBCOMMITTEE ON ACUTE EXPOSURE GUIDELINE LEVELS 14 Page 16, Section 5.3. “inappropriate” needs more argumentation. There is a TLV-STEL of 1 ppm; that value would fit into the data set, compared with AEGL-2 value. Page 19. There needs to be discussion of the fact that the ERPG-2 is 0.5 ppm, while AEGL-2 for 1 hr is 2 ppm. Explain the discrepancy between the derivation of the ERPG-2 and the AEGL-2 values. COMMENTS ON BORON TRICHLORIDE At its July 21–23, 2003 meeting, the subcommittee reviewed the AEGL document on boron trichloride. The document was presented by Claudia Troxel of Oak Ridge National Laboratory. The SOP manual should be updated to define the minimum data set necessary for AEGL development. The subcommittee recommends that it not review the current version of the AEGL document at this time. However, if the NAC is able to get additional data on this compound, AEGL values can be developed with greater confidence and validity. The comments below are offered by the subcommittee should the NAC reconsider the database and continue to pursue development of AEGLs. General Comments There are few human or animal toxicity data for boron trichloride (BCl3). There are only two animal toxicity studies, an LD50 (Vernot et al., 1977) and a pilot study (Stockinger and Spiegel, 1953). The subcommittee discussed whether there was sufficient information to establish AEGL values and concluded that additional information is needed to justify development of AEGLs for boron trichloride. There are too few data for AEGL development, and the many assumptions reduce confidence in the AEGL derivation. Given the paucity of data, consideration should be given to revision of the SOP manual to define the minimum data required for development of any AEGL document. Furthermore, consideration should be given to deleting boron trichloride from the AEGL development process until more data become available to derive rigorous AEGL values for this substance. AEGL-1 and AEGL-2 values are derived by analogy (a surrogate approach) to hydrogen chloride (HCl), and the document contains detailed information (e.g., studies, uncertainties) about the HCl AEGLs. The subcommittee agreed that the detailed HCl information should be deleted and replaced by reference to the HCl AEGL document (see also Specific Comments). AEGL-1: Summary: The paucity of data on boron trichloride precludes derivation of AEGL-1. The AEGL-1 value in the TSD is based on HCl as a surrogate chemical and a proposed mechanism that boron trichloride theoretically hydrolyzes to form 3 moles of HCl in moist air. As there are no relevant data available for boron trichloride, the proposed AEGL-1 for boron

Next: Specific Comments »
Tenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels Get This Book
×
MyNAP members save 10% online.
Login or Register to save!
  1. ×

    Welcome to OpenBook!

    You're looking at OpenBook, NAP.edu's online reading room since 1999. Based on feedback from you, our users, we've made some improvements that make it easier than ever to read thousands of publications on our website.

    Do you want to take a quick tour of the OpenBook's features?

    No Thanks Take a Tour »
  2. ×

    Show this book's table of contents, where you can jump to any chapter by name.

    « Back Next »
  3. ×

    ...or use these buttons to go back to the previous chapter or skip to the next one.

    « Back Next »
  4. ×

    Jump up to the previous page or down to the next one. Also, you can type in a page number and press Enter to go directly to that page in the book.

    « Back Next »
  5. ×

    To search the entire text of this book, type in your search term here and press Enter.

    « Back Next »
  6. ×

    Share a link to this book page on your preferred social network or via email.

    « Back Next »
  7. ×

    View our suggested citation for this chapter.

    « Back Next »
  8. ×

    Ready to take your reading offline? Click here to buy this book in print or download it as a free PDF, if available.

    « Back Next »
Stay Connected!