Tenth Interim Report of the Subcommittee on Acute Exposure Guideline Levels (2004)

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TENTH INTERIM REPORT OF THE SUBCOMMITTEE ON ACUTE EXPOSURE GUIDELINE LEVELS 25 The justification on page 33 is appropriate for the 10-min AEGL values. The subcommittee recommends that the entire revised aniline document be included in the next AEGL volume. COMMENTS ON ARSINE At its July 21–23, 2003 meeting, the subcommittee reviewed the AEGL document on arsine. The document was presented by Robert Young of Oak Ridge National Laboratory. The subcommittee recommends that the following revisions be made. This document can be finalized if the recommended revisions are made appropriately. Comments Development of 10-min AEGLs for Arsine The subcommittee's concern for arsine is the same as previously discussed for aniline. The revised document is identical to that published in AEGLs Volume 1 (NRC 2000) and the derivation of the AEGLs in the appendix is also identical to that in Volume 1 except for addition of 10-min AEGL values. The subcommittee must be assured that all relevant new data have been considered and that there are no new data that would alter the previously recommended AEGLs for arsine. Page 3. A decreased hematocrit is not a sensitive indicator of arsine toxicity because it reflects chronic anemia. An increase in plasma hemoglobin (or potassium) is a better indicator for acute hemolysis. Page 5. AEGLs-2 end point: How can absence of an effect be consistent with arsine toxicity? High-susceptibility groups have to be defined (sickle cell anemia; G6PD-deficiency). The garlic odor of arsine was used until 1840 without too many casualties. It would be relevant to know how the odor threshold compares with the proposed AEGLs. The document should provide the odor threshold value of arsine in air. Delete calculation for AEGL-1 values. COMMENTS ON MONOMETHYLHYDRAZINE At its July 21–23, 2003 meeting, the subcommittee reviewed the revised AEGL document on monomethylhydrazine. The revised document is identical to that published in AEGLs Volume 1 (NRC 2000), and the derivation of the AEGLs in the appendix is also identical to that in Volume 1 except for addition of 10- min AEGL values. The subcommittee must be assured