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Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 499
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 500
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 501
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 502
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 503
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 504
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 505
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 506
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 507
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 508
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 509
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 510
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 511
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 512
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 513
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 514
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 515
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 516
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 517
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 518
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 519
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 520
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 521
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 522
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 523
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 524
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 525
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 526
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 527
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 528
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 529
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 530
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 531
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 532
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 533
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 534
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 535
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 536
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 537
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 538
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 539
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 540
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 541
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 542
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 543
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 544
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 545
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 546
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 547
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 548
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 549
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 550
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 551
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 552
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 553
Suggested Citation:"Part 3: Information and Data Resources." Institute of Medicine. 1988. Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources. Washington, DC: The National Academies Press. doi: 10.17226/1090.
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Page 554

Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Part 3 Information and Data Resources

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Part 3: Information and Data Resources This part has three sections: a categorical chart of information and data resources beginning on page 501, the 73 resource descriptions beginning on page 504, and a subject index to the resource descriptions beginning on page 551. The categorical chart indicates which of three broad types of descriptors, i.e. file type, format, and access, characterizes each resource. The descriptions of each of the 73 information and data resources are arranged alphabetically by name of resource; each is described in terms of source, subject, content, compilation, and access. The subject index is for identifying information and data resources relevant to particular topics. BOO

INFORMATION AND DATA RESOURCES Categories of Infonnation and Data Resources I doe .~ 1_ A ~e,~ 39- ~ Aid\ fit ~ /~ Abstracts of Health Care Machine-Readable Data Files ADAMHA Publications and Data AMA/NET Baseline Reports BIOETHICSLINE Birth Defects and Developmental Disabilities Reports BMEDSS Boston Collaborative Drug Surveillance Program BPS/SEARCH CANCERLIT CASSIS CCC Bibliography on Regional Variations in Health Care Center for Health Promotion and Education CLINPROT COLLEAGUE COMPASS, DURbase Compendium of HHS Evaluations and Relevant Other Studies CPHA Files CRISP Current Assessments New Technology Abstracts ~4 · . · . · · _ continued ~%,~9 501

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Categories of Information and Data Resources \ Device Experience Network DIALOG Directory of Health Services and Research Organizations DIRLINE Drug Product Problem Reporting Program Duke Comprehensive Cancer Center Database Environmental Hazards and Health Effects Reports Environmental Health Laboratory Sciences Reports FDA Bulletin Board F-D-C Reports Futures Program HEALTH Health Devices Alerts Health Devices Sourcebook Health Information Resources in the Federal Government HEALTHLAWYER HECLINET HIAA Medical Appropriateness Compilation High Blood Pressure Information Center IMPAC IMS Audits International Market Research Studies INTERNIST- 1/ QUICK MEDICAL REFERENCE Market Research Reports Market/Technology Reports Medical Device and Laboratory Product Problem Reporting Program Medical Device Register 502 \ ~ ~ Ace' , ~_ -, ~ · ~ ~ ~ .+ \,~9

INFORMATION AND DATA RESOURCES Categories of Information and Data Resources  .^ MEDLINE MEDLINK Multi-Client Reports NAHDO Resource Manual NCHS Publications and Data National Cholesterol Educ Prog/ NHLBI Smoking Educ Prog Info Ctr National Reference File NTIS Publications and Data NEXIS NHLBI Publications Oxford Database of Perinatal Trials PDQ Pharmaprojects POPLINE Product Development Directory Product SOS Randomized Controlled Clinical Trials Report Collection Report on Cost-Effective Products and Technologies Scrip SEER SPRILINE Technical Data Center U.S. Industrial Outlook WHO/LINFO Database on Health Technology Assessment WHO Publications Cal An' Medical Device Reporting l | · | | | | :~ 1 :41 ~4 503

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Abstracts of Health Care Machine-Readable Data Files Source: Hospital Data Center, Department of Special Studies, American Hospital Association (AHA), 840 North Lake Shore Drive, Chicago, IL 60611, 312-280-6520 Subject: Machine-readable databases related to health care that are national in scope and are available to users outside the source organizations, with or without restrictions on use or conditions of release. Content: The 1986 version contains 137 abstracts of non-bibliographic machine-read- able files. Each abstract includes the file citation, brief narrative description, descriptors based on NLM controlled vocabulary MeSH, geographic coverage, time coverage, technical notes, information about related files, availability, and contact person. The abstracts are arranged alphabetically by title and are indexed by source and by MeSH. The 1986 version is an expansion and updating of shorter descriptions of 257 data- bases contained in the 1984 version. The forthcoming version will be an expansion and update of the two earlier documents. Compilation: All versions were compiled by the AHA from survey forms sent to source organizations. Databases listed include data pertaining to periods later than January 1, 1970. Access: The 1 986 volume Abstracts of Health Care Machine-Readable Data Files ( 157 pages) is available from the AHA Hospital Data Center; price to be set by AHA. Its predecessor, the 1984 Inventory of U.S. Health Care Data Bases 1976-1983, was originally published by HRSA, and is available from NTIS (order HRP0906300LP) for $18.95 plus $3 handling. An updated version, Inventory of Machine-Readable Healthcare Data Bases will be available in 1988; price to be set by AHA. Alcohol, Drug Abuse, and Mental Health Administration Publications and Data Source: Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA), Park- lawn Building, Room 13C-05, 5600 Fishers Lane, Rockville, MD 20857, 301-443-3820 Subject: Alcohol, drug abuse, and mental health (ADM) disorders. Content: Publications and data cover statistical, epidemiological and services research information pertaining to substance abuse and mental health disorders and their public health implications. Includes ADM client/patient data, research findings on ADM disorders, facility service and resources information, and financial data. Also available: directory of organizations involved in ADM research, treatment, and related issues. 504

INFORMATION AND DATA RESOURCES Compilation: Most ADAMHA activities initiated in 1972. Information gathered from clients in treatment; facilities providing alcohol, drug abuse, and mental health treat- ment and prevention services in U.S., Puerto Rico, and six territories. Publications issued periodically. Access: Alcohol, Drug Abuse, and Mental Health Administration (ADAMHA' publi- cations are available free of charge by contacting individual institutes within ADAMHA, i.e., National Institute on Drug Abuse (NIDA) 301-443-4577, National Institute on Mental Health (NIMH) 301-443-4515, National Institute on Alcohol Abuse and Alcoholism (NIAAA) 301-443-2954. Studies independently conducted for use by NIAAA, NIDA, NIMH; IBM-compatible data tapes available from sponsoring Institute, price to be determined. Sample formats of particular data collections or surveys are available from sponsoring Institutes. AMA/NET v Source: SoftSearch, Inc., 1560 Broadway, Suite 900, Denver, CO 80202, 303-832- 7111, 800-426-2873. Sponsored by the American Medical Association (AMA). Subject: Medicine and health care delivery; designed for health care professionals. Content: AMA/NET provides the following databases. AP MEDICAL NEWS SERV- ICE is a compendium of health care-related articles selected from Associated Press news wires and U.S. newspapers. EMPIRES CURRENT AWARENESS provides ac- cess to specialty specific citations; contains references to articles from over 300 interna- tional medical and scientific journals covering some 65 medical specialties and subspe- cialties. DISEASE INFORMATION is a reference summary of more than 3,500 ct~st~nct diseases, disorders, and conditions; provides synopsis of classic signs and symptoms as well as laboratory and radiologic findings of the entities. MEDICAL PR(~(:EDURE CODING & NOMENCLATURE, based on AMA publication Physi- cians' Current Procedural Terminology includes descriptive terms and billing codes for more than 6,000 medical procedures and services performed by physicians. SOCIO/ ECONOMIC BIBLIOGRAPHIC INFORMATION contains over 5,500 citations to documents pertaining to health care delivery and economic issues in medicine. Also available are electronic communications services, including electronic mail and bulletin boards; public information services providing direct access to such government organizations as the Centers for Disease Control, the Surgeon General's Office, and the National Library of Medicine/National Institutes of Health; AMA; literature ordering service providing reprints of articles referenced in either the SOCIO/ECONOMIC BIBLIOGRAPHIC INFORMATION or EMPIRES databases; interactive, computer- based continuing medical education courses developed at the Massachusetts General Hospital Laboratory of Computer Science. ~ 1 ' Compilation: Databases compiled from journal articles, legislative reports, books, wire services, and newspapers. AP MEDICAL NEWS SERVICE updated daily; EMPIRES updated weekly. Access: Online databases and other services available at any time; accessible via modem from remote terminal. Subscription required. One-time subscription fee ($30 for AMA members, $50 for non-members) includes one user name and introductory materials. Registration fee for each additional user $15. Basic service charge $14/hour peak time; $10/hour off-peak. Information service charge varies with service used. 505

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Baseline Reports Source: Massachusetts Health Data Consortium, Inc., 400-1 Totten Pond Road, Wal- tham, MA 02154, 617-890-6040 Subject: Diagnosis, treatment, costs, and outcomes of all patients discharged from acute care hospitals in Massachusetts. Content: Database covers information on hospital utilization, hospital charges, patient socio-demographic characteristics, clinical status including principle diagnoses and procedures, and discharge status. The following types of reports and data sets are available. Patient origin report sets identify hospital service areas and community dependency for pediatrics, medical/surgical, obstetrics/gynecology, and psychiatry. Market position reports analyze market penetration by town, age, and payer. Market position trend analyses chart market share changes over time by hospital for 24 clinical specialties. Statewide summary charge data reports rank top 100 diagnosis-related groups (DRGs) by payers, hospital bed size, patient discharge status, sex, and age. Hospital-specific charge data reports highlight charges and length of stay by DRGs. Case mix profiles display a case mix adjustment factor and length-of-stay performance measures. Per diem charge profiles provide case mix adjusted per diem charges for Blue Cross and commercially insured patients. Payer mix trend analyses display changes in payer mix for 24 clinical specialties. Community use rate reports contain population-based discharge and use rates. DRG outlier and mortality reports include hospital-specific length of stay, deaths, and outliers by DRG. Data express service provides custom reports in response to special requests for data or analyses. Compilation: Information gathered from data tapes supplied by 109 acute care hospi- tals and two Veterans Administration hospitals in Massachusetts and surrounding communities. Coverage from 1978 to present; updated annually. Access: Free catalog of publications available upon request. Report prices range from $75 to $1,850. Database available online; accessible via modem from remote terminal. BIOETHICSLINE Source: Bioethics Information Retrieval Project, Kennedy Institute of Ethics, George- town University, Washington, DC 20057, 202-687-3885 Subject: Multidisciplinary coverage of the ethical, legal, and public policy aspects of medicine, health care, and biomedical and behavioral research. Content: Database includes bibliographic citations to documents relating to euthanasia, organ donation and transplantation, allocation of health care resources, patients' rights, codes of professional ethics, in vitro fertilization and other reproductive technol- ogies, genetic intervention, abortion, behavior control and mental health therapies, and human experimentation. About 20 percent of citations include abstracts. Approxi- mately 80 percent of database keywords are mapped to terms in NLM controlled vocabulary MeSH, making it possible to search BIOETHICSLINE using MeSH. See MEDLINE description for listing of NLM MEDLARS databases. 506

INFORMATION AND DATA RESOURCES Compilation: Compiled from journal articles, monographs, newspaper articles, court decisions, bills, laws, audiovisual materials, and unpublished documents. Coverage from 1973 to present. Updated bimonthly with approximately 2,000 citations added annually. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. To contact MEDLARS Manage- ment Division call 800-638-8480 or 301-496-6193 in Maryland. Call source for search strategies and further information about Bibliography of Bioethics and related services. Connect cost averages $22/hour peak time, $15/hour off-peak. Individual searches available free of charge from the affiliated National Reference Center for Bioethics Literature 800-633-3849; citations are printed offline and arrive in about one week. Printed bibliographies on selected topics are available bimonthly ($10/topic, $60/complete package). BIOETHICSLINE citations Nor in print form in the annual Bibliography of Bioethics ($25~. Birth Defects and Developmental Disabilities Reports err -~- Source: Division of Birth Defects and Developmental Disabilities (BDDD), Center for Environmental Health, Centers for Disease Control, 1600 Clifton Road, Atlanta, GA 30333, 404-454-4706 Subject: Adverse reproductive outcomes, congenital malformations, genetic diseases, and other diseases or conditions that originate before birth or that develop during childhood. Content: BDDD surveillance activities include the following programs. Metropolitan Atlanta Congenital Defects Program (MACDP) monitors occurrence of congenital malformations (e.g., structural, chromosomal, or biochemical abnormalities) in Atlan- ta-area hospitals and maintains a case registry for epidemiologic and genetic studies. Birth Defects Monitoring Program (BDMP) monitors U.S. incidence of birth defects; functions primarily as an early warning system for correlating incidence patterns with temporal and geographic distribution of drugs, chemicals, other possible human te- ratogens. Developmental Disabilities Surveillance Program collects and analyzes data on developmental disabilities in 10 year-olds in Atlanta area. Data include statistical information for trend analysis and selected regional comparisons. Compilation: MACDP initiated in 1967; BDMP initiated in 1975; Developmental Disabilities Surveillance initiated in 1985. BDMP data gathered from hospital discharge data on newborns. MACDP drawn from Atlanta-area hospital records. Disabilities Surveillance Program drawn from educational and health care providers records. MACDP updated monthly; BDMP updated quarterly. Surveillance reports published . . Intermittent Y Access: Copies of Congenital Malformations Surveillance reports available upon request. All data maintained in computer files is for access by CDC staff; no public use data tapes available. Staff may prepare documents or data sets in response to justified individual requests made directly to BDDD for specific data or information. 507

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY BMEDSS (Biomedical Engineering Decision Support Services) Source: Medical Engineering Department, Akron City Hospital, 525 East Market Street, Akron, OH 44309-2090, 216-375-3501 Subject: Pharmaceuticals, medical devices and equipment. Designed primarily for biomedical engineers, device/equipment manufacturers, purchasing agents, materiel managers, biomedical research and teaching professionals. Content: BMEDSS databases include FDA ENFORCEMENT REPORTS on medical devices and lab reagents, FDA RECALL REPORTS on pharmaceuticals, FDA TALK PAPERS, FDA MEDICAL DEVICE BULLETIN, FDA DEN (Device Experience Network) and MDR (Medical Device Reporting) as formatted and coded by ECRI, abstracts from Journal of Clinical Engineering from 1976 to present, abstracts of AAMI (Association for the Advancement of Medical Instrumentation) publications including National Standards and Recommended Practices, Technology Assessment Reports, Updates and Information Reports, and Medical Instrumentation; ECRI databases including HDA (Health Devices Alerts), abstracts and indexes of ECRI publications. Other services include User Report Forum that allows device experiences to be entered onto FDA DEN; Inventory Comparison Program permits in-house medical device inventories to be compared to current FDA recall file and ECRI's HDA and DEN files and automati cally flags recalled equipment; electronic mail and bulletin board. Compilation: Information gathered from FDA sources, ECRI publications and data- bases, professional journals, and other relevant publications. Databases updated monthly. BMEDSS initiated in 1984. Access: Databases available online through COMPUSERVE 800-848-8990; accessible via modem from remote terminal. Charges are $50 subscription fee plus approximate- ly $35/month and $35/connect hour, adjusted for usage. Special group rates available. Connect cost varies with service used. Reprints of abstracts are available; contact BMEDSS for further information. Boston Collaborative Drug Surveillance Program Source: Boston University Medical Center, 400 Totten Pond Road, Waltham, MA 02154, 617-890-1300. Supported by the FDA and the pharmaceutical industry. Subject: Postmarketing drug surveillance. Content: Program monitors clinical effects of drugs routinely prescribed to hospital- ized and ambulatory-care patients. Database includes information on frequency and importance of adverse drug reactions, adverse reaction rates, adverse reaction causa- tion, assessment of adverse drug interactions, unsuspected drug side effects, drug efficacy, and evaluation of the role of certain patient characteristics in influencing clinical drug effects. Information is also available regarding drug utilization and pre- vailing practices in drug therapy such as magnitude of drug use, frequencies of various indications, utilization of specific drugs, and variability of utilization patterns by hospi- tal and geographic area. 508

INFORMATION AND DATA RESOURCES Compilation: Program implemented in 1966. Studies use data from two primary sources: drug use experience of 50,000 people hospitalized in one of eight hospitals in the U.S., Canada, and Israel; and members of Group Health Cooperative of Puget Sound (GHC) in Seattle, Washington. Hospital data include records of all drug expo- sures and all adverse events at the selected hospitals. Automated data files received from GHC on annual basis include all prescriptions and refills filled by GHC members at one GHC pharmacy, hospitalizations of GHC members, and routine information on GHC members. Access: Boston Collaborative Drug Surveillance Program (BCDSP) computer tapes are not in the public domain. Contact BCDSP regarding access to data resources in collaboration with BCDSP. Over 200 articles describing past BCDSP studies have been published in various medical and professional journals. Reprints are available upon request. Listing of publications is available in: Cohen, M.R. A Compilation of Abstracts and Index Published by the Boston Collaborative Drug Surveillance Program 1966-1985. Hospital Pharmacy 21:497-559, 1986. BPS/SEARCH Source: BRS Information Technologies, 1200 Route 7, Latham, NY 12110, 800-345- 4277 Subject: Health, medicine, pharmacology, biosciences, science and technology, educa- tion, business and finance, social sciences, politics, humanities. Content: BPS/SEARCH Service includes over 90 multidisciplinary databases. Among those relevant to medical technology are MEDLINE, HEALTH, PDQ, HEALTHLAWYER, DRUG INFORMATION FULL TEXT (full-text information on current and investigational drugs, including research, treatment, and pharmacolog- ical practice), INTERNATIONAL PHARMACEUTICAL ABSTRACTS (indexes and abstracts from international pharmaceutical and health-related journals, covering drug development, use, and professional pharmaceutical practice), DIOGENES (FDA Medical Device Reporting, other regulatory information), EMBASE (from Excerpta Medica; references and summaries of international medical literature covering bio- medicine, health, and health care management), IRCS MEDICAL SCIENCE DATA- BASE (full-text articles on biomedical research). Many databases provide bibliographic citations, many include abstracts; others provide complete document texts; most are indexed by title, subject, author, publication date. Monthly BRS Bulletin provides information on new databases, developments, and features. Compilation: Databases are compiled from journal articles, books, periodicals, disser- tations, monographs, government reports, corporate reports, newspaper articles. Most references are updated monthly; newspaper files are updated daily. Access: Databases available online; accessible via modem from remote terminal through TELENET, TYMNET, OCLC GATEWAY, IN-WATS, direct dial. Outside U.S. and Canada, accessed through BRSNET. Online or offline document printing. Subscription required. Two basic subscription plans offered: ( 1 ) basic plan allows access to BRS on an as-needed basis; annual password fee ($751; connect cost ($25/hour plus database royalties), telecommunications, and document charges; (2) advance purchase plan provides volume discounts; a variety of subscription levels available. User manual ($45), database guides ($5 each), database summaries, and catalog available to subscrib- ers. Training seminars offered in BPS/SEARCH features and search procedures. 509

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY C A N C EEULIT Source: International Cancer Information Center, Office of International Affairs, National Cancer Institute (NCI), Building 82 Room 103, Bethesda, MD 20892, 301- 496-7403 Subject: Major cancer topics. Content: Database includes more than 600,000 citations and abstracts of published cancer literature and other sources. All records from non-MEDLINE sources contain abstracts; more than 60 percent of MEDLINE-derived records include abstracts. Re- cords added since January 1980 have been indexed using NLM controlled vocabulary MeSH. All records are retrievable by free-text searching. See MEDLINE description for listing of NLM MEDLARS databases. Compilation: Compiled from articles appearing in approximately 2,000 biomedical journals, government reports, meeting abstracts, papers presented at conferences, books, monographs, theses and dissertations. Most journal literature is derived from MEDLINE. Approximately 200 additional foreign journals and published literature references are also screened. 5,000 new references are added monthly. Access: Ava~ia0ie online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. To contact MEDLARS Manage- ment Division call 800-638-8480 or 301-496-6193 in Maryland. Connect cost averages $22/hour peak time, $15/hour off-peak. Also available through BRS 800-345-4277, COLLEAGUE (BRS/Saunders) 800-468-0908, and DIALOG 800-334-2564. CASSIS (CIassif~cation and Search Support Information System) Source: Patent Depository Library Program Office, Patent and Trademark Office, U.S. Department of Commerce, Washington, DC 20231,703-557-9686 Subject: Patent information of the U.S. Patent and Trademark Office. Content: Encompasses information on the 4.9 million U.S. patents. Generally used to search classes and subclasses of patents in order to identify patent numbers that may be used to locate patent documents in microfilm holdings of Patent Depository Libraries. CASSIS searches or displays classifications of patents, patents in classifications, struc- tured classification titles, keywords in classification titles, keywords in patent abstracts, and terms in the patent classification index. Within the patent classification system, the following are examples of classes of patents that pertain to medical technologies: surgery (classes 128 and 604~; drugs, bio-affect- ing, and body treating compositions (424,5 14~; dentistry (4331; prosthesis, i.e., artificial body members, parts thereof, or aids and accessories therefore (6231; genetic engineer- ing technology (935~; multicellular living organisms and unmodified parts thereof ~ ~ A ~ ~ ~ ~ ~ . . . . t500); chemistry: molecular biology and microbiology (4351; chemistry: analytical and immunological testing (436~; eye examination, vision testing, and correcting (3511. Each class has many subclasses. 5IO

INFORMATION AND DATA RESOURCES Compilation: Operational since the late 1970s. Updated continuously; information about a new patent appears in the system approximately two months after it is issued. Although all patent numbers and classification information remain on the system, patent abstracts are rotated off after one to three years. Access: Available online at no charge through any of the 60 Patent Depository Librar- ies located in 38 states in the U.S. No direct access from other remote terminals. CCC (Copenhagen Collaborating Center) Bibliography on Regional Variations in Health Care Source: Copenhagen Collaborating Center for the Study of Regional Variations in Health Care, Institute of Social Medicine, University of Copenhagen, Panum Institute, Blegdamsvej 3, 2200 Copenhagen N., Denmark, (45-1) 35-79-00 Ext. 3011. CCC is a World Health Organization (WHO) Collaborating Center established by four Danish ~ . . research Institutes. Subject: Regional variation in the provision, utilization, and outcomes of health care. Content: Studies covered in bibliography focus on small area variations, employ epide- miological methods, and include interpretation and discussion of variations. 1986 bibliography contains 153 entries, abstracts/extracts, author and subject index. Quar- terly International Newsletter on Regional Variations in Health Care reports regional varia- tions in medical practice, practice outcomes, clinical decision-making processes. Other articles include meeting announcements, summaries of proceedings, international activities in technology assessment, e.g., WHO Global Programme for Appropriate Health Care Technology. Also available is a directory of persons and institutions interested in regional variations in health care. Other CCC activities include research, organization of international meetings, and international research training. Compilation: Bibliography compiled through unpublished literature reviews and in- formation from researchers in the field. Data for other organizational and information activities are acquired through questionnaires sent to individuals and research insti- tutes. CCC activities initiated in 1985. First bibliography was published in 1986; to be updated periodically. Directory is updated continuously. Access: Online text retrieval and literature searches available from Danish Hospital Institute. Printed copy of bibliography and copies of newsletter available upon request. Contact CCC about receiving newsletter on regular basis. Center for Health Promotion and Education Source: Centers for Disease Control (CDC), 1600 Clifton Road, Atlanta, GA 30333, 404-32 1-2263 Subject: Nutritional status of select U.S. populations, behavioral risk factors, women's reproductive health. 511

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Content: Reports and data tapes from Center for Health Promotion and Education's (CHPE) national surveillance activities cover nutritional status of high-risk pediatric populations and low-income, high-risk pregnant women, adolescent pregnancy, infant mortality, abortion, and behavioral risk factors such as smoking, hypertension, obesity, and alcohol use.-Areas of applied research include female reproductive cancer and endogenous hormones, and the safety and efficacy of tubal ligation/female sterilization procedures. Data include statistical and demographic information which permit trend analysis and select regional comparisons. Compilation: CHPE established in 1981. Information gathered primarily from state health departments, clinics, and select health and nutrition programs, e.g., Supplemen tal Food Program for Women, Infants, and Children (WIC), Early and Periodic Screening, Diagnosis, and Treatment (EPSDT) program. Information on behavioral risk factors gathered through telephone surveys by states. Reports usually issued annually. Access: Reports available upon request, free of charge. Contact CHPE) for further information regarding access and availability of public use data tapes. CLINPROT Source: International Cancer Information Center, Office of International Affairs, National Cancer Institute (NCI), Building 82 Room 103, Bethesda, MD 20892, 301- 496-7403 Subject: Clinical investigations of new anti-cancer agents and treatment modalities. Content: Database contains comprehensive information on approximately 6,000 ex- perimental cancer therapy protocols from the U.S. and other countries; approximately 1,500 are active protocols and over 4,000 are completed studies. Protocol summaries provide descriptions of clinical trials, including protocol objectives, study outline, pa- tient entry criteria, treatment regimen, special study parameters, and status of the protocol. Active protocols indexed according to type and stage of cancer treated, phase of clinical investigation, specific agents or combination of agents, treatment modalities. Records retrieved by free-text searching or by using the 300 clinical protocol terms used for indexing. See MEDLINE description for listing of NLM MEDLARS data- bases. Compilation: Coverage from 1960 to present. Currency and accuracy of information are maintained through monthly updates. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. To contact MEDLARS Manage- ment Division call 800-638-8480 or 301-496-6193 in Maryland. Connect cost averages $22/hour peak time, $15/hour off-peak. 512

INFORMATION AND DATA RESOURCES COLLEAGUE Source: BPS/Saunders, 1290 Avenue of the Americas, New York, NY 10104, 800-468- 0908 Subject: Health care, medicine, pharmaceuticals; designed for health care profession- als. Content: Medical Search Service offers bibliographic sources including MEDLINE, HEALTH, EMBASE (from Exerpta Medical, BIOSIS PREVIEWS, INTERNATION- AL PHARMACEUTICAL ABSTRACTS, COMPREHENSIVE CORE MEDICAL LIBRARY, and PDQ. Medical and Psychological Previews Service permits access to citations from over 200 journals indexed by title and author prior to their inclusion in MEDLINE; also includes editorials, letters, and clinical notes. Complete Text Library incorporates full text of more than 20 medical books and textbooks in critical care medicine, and more than 50 medical and health-related journals. General Searching Service allows access to 70 other nonmedical databases offered by BRS. Electronic mail and bulletin boards are available through COLLEAGUE Mail service. Compilation: Databases compiled from journal articles, periodicals, textbooks, mono- graphs, medical manuals. Most references updated monthly; Medical and Psychologi- cal Previews updated weekly. Access: Databases available online; accessible via modem from remote terminal through TELENET, TYMNET, direct dial. Online or offline document printing are available. Connect cost $32 to $79/hour peak time, $20 to $69/hour off-peak. Connect time volume discounts available. Subscription required. One-time registration fee ($95/ individual. $175/~rouni. includes nassworcl Il.~er manila once cilnn~rt c~rvir`~ Tllt~ri 1 ~ ~ 1 ~ ~ ~ ~ ~ ~ ^ _ ~ _ r r A ~ ~ ~ V ~ A ~ ~ ~ al diskettes explaining COLLEAGUE and search strategies available upon request. COMPASS (Computerized On-Line Meclicaid Pharmaceutical Analysis and Surveillance System), DURbase (Drug Utilization Review base) Source: Health Information Designs, Inc. (HID), 1616 North Fort Meyer Drive, Suite 1420, Arlington, VA 22209, 703-528-2032 Subject: Postmarketing drug surveillance. Content: COMPASS database is composed of patient-specific billing data, including age, sex, state, inpatient and outpatient diagnoses recorded by ICD-9-CM codes, and outpatient drugs dispensed. Drug data are retrievable by strength, generic name, therapeutic class, or manufacturer. Database is supplemented by data on mortality, maternal-child linkages, and nursing home status. Reports available on individual patient diagnosis and prescription profiles, rankings of drugs and diagnoses, demo- graphic characteristics, drug use patterns, average daily doses for specific drugs, com- parisons of clinical outcomes between patients receiving specific drugs and control groups, and temporal relationships between specific drugs and subsequent diagnoses. 513

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY DURbase is a computerized drug utilization review system for identifying patients at high risk for drug-induced illness. Reports include chronological listings of all pharma- ceuticals for patients identified as being at risk for drug-induced illness, summaries of individual patient prescription patterns, and other services. Compilation: COMPASS and DURbase are drawn from HID database consisting primarily of billing data covering hospital, dental, and pharmaceutical services provid- ed to 9 million patients, including 7 million Medicaid patients from 11 states and 2 million patients from HMOs, major employers, and other private sector sources. Medicaid data come from state Medicaid Management Information Systems. More than 20 million encounter records are added to the database monthly, including 7 million prescription drug claims. System includes data collected since 1980. Access: COMPASS is used primarily by the FDA and pharmaceutical companies for postmarketing surveillance. DURbase is used primarily by government and private sector providers and payers for drug utilization monitoring and related quality review activities for their patient groups. Most HDI products are in the form of reports generated from COMPASS and DURbase data and analysis. Report prices depend upon the amount of data, level of analysis, and computer time required; charges for COMPASS products may range from $2,000 to $250,000. Online access to COMPASS is available only to the FDA. DURbase charges generally are based upon the size of the patient group studied and a per patient record charge. Patient group sizes range from 10,000 to 1.5 million people for certain Medicaid data sets. Charge per patient record ranges from $0.60 to $1.25 depending upon the extent to which HDI is asked to undertake clinical review of the data. Compendium of HHS Evaluations and Relevant Other Studies Source: HHS Evaluation Documentation Center (EDC), Office of the Assistant Secre- tary for Planning and Evaluation, U.S. Department of Health and Human Services (HHS), Room 438F Humphrey Building, 200 Independence Avenue, SW, Washing- ton, DC 20201, 202-245-6445 Subject: Examples from 300-term subject index are ambulatory and outpatient health care, biomedical research, drugs therapeutic and devices, economic analysis, health care delivery systems, health insurance and financing, information systems, medical practice, medical technology, quality assurance, and utilization review. Content: Project descriptions of in-process and completed evaluations from the Office of the Secretary of HHS, HCFA, PHS (e.g., ADAMHA, CDC, FDA, HRSA, NIH, DASH), Social Security Administration, and other agencies. Compendium is organized by HHS operating divisions and agencies; it includes project descriptions (1,800 in 1985 edition), a subject index, agency sponsor index, and program name index. Project descriptions include agency sponsor, project title, report title, performer, agency con- tact, programs evaluated, abstract, access descriptors, and other information. The 1985 edition is 926 pages long; the 1987 edition is approximately 1,100 pages long. Compilation: Compiled from one-page descriptions of all ongoing and completed HHS evaluation studies carried out since the early 1970s. EDC first published project descriptions of HHS evaluation activities in 1976. System was computerized in 1979. Database was expanded in later years to include more agencies. 514

INFORMATION AND DATA RESOURCES ~ 1: d ~ ~1 ~1 ~ c) to ~- 1 . - Access: Copies of Compendium, a bound volume, may be obtained from NTIS 703-487- 4650. 1985 (fifth) edition (order PB86112281) price is $66.95 plus $3 handling. Sixth Saloon aue summer 1Y5/. for electronic access to the EDC database, users must register with EDC and have an account with the Parklawn Computer Center. EDC makes available Users Guide to the Evaluation Documentation Center and Sponsors Guide to the Evaluation Documentation Center. The quarterly Memorandum provides information on EDC acquisitions as they occur. CPHA (Commission on Professional and Hospital Activities) Files Source: CPHA, 1968 Green Road, PO Box 1809, Ann Arbor, MI 48106. 800-521- 6210, 800-828-6762 in Michigan Subject: Computerized patient discharge data. Content: National Inpatient Profile is a diagnosis and procedure utilization data set drawn from the CPHA National Patient Sample File. Two-volume annual set is se- quenced by ICD-9-CM diagnoses and procedures. The summary profile section pro- vides overview of projected number of principal and secondary diagnoses or proce- dures treated in U.S. hospitals. The detail profile displays demographic, clinical, and facility characteristics of these diagnoses and procedures. For each ICD-9-CM code, data are provided on patient demographics, patient clinical information, number and percent of patients having the code as a principal procedure, number and percent of occurrences of the code as a secondary procedure, and hospital facility information. Other standard CPHA data sets include Cost Containment Series: Length of Stay and Medicare Ancillary Charge Norms, Quality of Care Series: Case Fatalities by DRG, and National Outpatient Profile. National Patient Sample File is also used to generate other data files and customized data sets on, e.g., newborns, inpatient charges, and trends in occurrences of diseases and procedures. Compilation: CPHA files are compiled from patient discharge data from more than 1,400 hospitals, covering 10 million patients and 25 percent of North America's acute care hospitalizations. National Patient Sample File is based on 2 million patient sample drawn every year. CPHA archive maintains a total of 300 million patient records. For some files, CPHA merges its patient data with institutional data from the American Hospital Association and other sources. Access: CPHA files are available as hard copy reports, on floppy disk, or magnetic tape. Charge for National Inpatient Profile is $5,000 to commercial and $750 to non-commer- cial buyers. Charge for National Outpatient Profile is $3,000 to commercial and $500 to non-commercial buyers. Charge for Length of Stay information sets (one each on diagnoses and procedures) is $85 for books and $4,500 for tapes. Prices for customized statistical reports vary; typical charge m~vhe.~.~()() orl`>ccif alien t is ~ roods 1 lair Cl ~hc~rih~r to CPHA information services. ~-_ - ~ - - ~ ~b ~ 'I ^ v ~ i_ ~ ~ ^ A Am ~ 4 CRISP (Computer Retrieval of Information on Scientific Projects) Source: Statistics and Analysis Branch, Division of Research Grants (DRG), National Institutes of Health, Bethesda, MD 20892, 301-496-7543 5~5

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Subject: Scientific information on extramural research projects supported through grants and contracts programs of NIH, ADAMHA, and other PHS agencies, as well as intramural research projects conducted by NIH and ADAMHA. Content: In general, information from CRISP can take the form of topical scientific information or institution-based scientific profiles. The five files of CRISI? computer information system use disk storage for random and sequential access. CRISP is capable of subdividing program projects, center, and other multifaceted projects into smaller research components. File 1 is a master dictionary of scientific subject headings corresponding to those appearing in MPIRST (Medical and Health Related Sciences Thesaurus used for describing research projects). File 2 stores the indexed subject heading numbers with their associated project numbers. File 4 serves to combine the data elements contained in the Files 1 and 2. File 3 is a project identification master file, consisting of information transferred from IMPAC (a related system dealing with administrative aspects of NIH extramural programs; see description), including pro- ject and subproject numbers and titles, investigators names and addresses, initial review group designations, institution codes, and amounts awarded. File 5 contains the investi- gator-prepared narrative for each project. The two-volume Research Awards Index, compiled from CRISP, contains project and contract information listed bv subject. project or contract number, and principal investigator. , ~ Compilation: Projects are indexed based on applications or progress reports for extra- mural research, and on annual reports or project narratives for intramural research. CRISP is updated twice weekly; intramural projects are reported and entered into CRISP annually. The project identification master file (File 3) is updated through weekly links with IMPAC. MHkST is updated semiannually. The Research Awards Index is published annually. Access: Direct access to CRISP files is available to all NIH staff with registered accounts by contacting DRG. Online access to selected data from the latest fiscal year files is available to outside individuals or organizations through subscription from NTIS 703- 487-4808. Current Assessments, New Technology Abstracts Source: New York State Center for Assessing Health Services, Health Services Center 4L 215, State University of New York at Stony Brook, Stony Brook, NY 1~1794, 516- 444-2101 Subject: Current Assessments covers public health, clinical and health services research; New Technology Abstracts covers innovations in health care technology and biomedical research. Content: Current Assessments provides annotated summaries of journal articles that report findings from public health, clinical, and health services research; and address the impact of technology on health policy. Summaries include reference citation, research findings, description of data source, study population, research methodology, study limitations, and implications of research for health care industry and subsequent policy decisions. 516

INFORMATION AND DATA RESOURCES New Technology Abstracts lists citations to journal articles and reports that cover new technologies in health care and biomedical research, or innovative applications of existing technologies. Also includes listings of FDA notices and notices from U.S. Patent Office. Center also conducts studies of the impact of changes in health ce~rvirec for health policy. Studies conducted during 1987 address innovations In Intensive home health care, regulation of risk in ambulatory surgery, organization of organ replacement services by states, and cost of inpatient treatment for patients with AIDS in four hospitals in metropolitan New York. Compilation: Journal articles were selected through monthly computer search of Index Medicos, Index to Dental Literature, International Nursing Index, Hospital Literature Index, and staff review of recent publications. Center also conducted monthly search of U.S. government technical and research reports listed in NTIS Bibliographic Data Base, FDA notices listed in Federal Register, and patents for medical devices reported in the Off cial Gazette of the U.S. Patent and Trademark Office. Publications were first issued in 1985. Current Assessments and New Technology Abstracts published every few months. Access: In 1987, the New York State Department of Health ended its cosponsorship of the Center, hence, publication of Current Assessments and New Technology Abstracts has been suspended. Back publications, reports, and copies of articles listed in New Technol- ogy Abstracts are available upon request. Device Experience Network (DEN) Source: Division of Product Surveillance, Office of Compliance, Center for Devices and Radiological Health, HFZ-343, Food and Drug Administration, 8757 Georgia Avenue, Silver Spring, MD 20910, 301-427-8100 Subject: Postmarketing surveillance of FDA-approved medical devices and in vitro diagnostic and laboratory products. Content: Computerized database contains voluntary reports from health care provid- ers and provider organizations concerning device-related hazards, defects, and defi- ciencies; these include performance failures, improper labeling, incomplete, inade- quate, or erroneous instructions, unsatisfactory packaging, or defective components. DEN identifies industry-wide problems and significant trends, e.g., product recalls and regulatory actions related to a particular product. Compilation: DEN consists primarily of information from the Medical Device and Laboratory Product Problem Reporting Program (PRP) administered by the United States Pharmacopeial Convention and the Medical Device Reporting (MDR) program of the FDA. Information is gathered from health care professionals, hospitals, state and local government, public~health officials, FDA field offices, contracting groups, con- sumer organizations, and consumers. Established in 1973. Updated continuously. Access: DEN reports accessible through BMEDSS 216-375-3501, National Technical Information Service 703-487-4630, Medical Device lkegister's Product SOS 203-348- 6319, and ECRI 215-825-6000. Confidential trade, commercial, financial, personnel, medical, and patient information are deleted from publicly available reports. DEN reports in microfiche and additional information about specific reports available from FDA, Freedom of Information Office, Room 12A16, WFI-31, 5600 Fishers Lane, 517

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Rockville, MD 20857, 301-443-6310. Monthly publication Device Experience Network Reports, which includes PRP but not MDR information, is available from FOI Services 301-881-0410 for $190. To report a device problem call U.S. Pharmacopeial Conven- tion 800-638-6725 or contact FDA. DIALOG Source: DIALOG Information Services, Inc., 3460 Hillview Avenue, Palo Alto, CA 94304, 800-334-2564, 415-858-3785 Subject: Databases cover biosciences, health care, medicine, science and technology, business and finance, law, government, social sciences, current affairs/news, human . . . sties, ec ucat~on. Content: Includes over 250 multidisciplinary databases. Those relevant to medical technology include BIOSIS PREVIEWS, CANCERLIT, CLINICAL ABSTRACTS (abstracts from journals covering clinical medicine, clinical practice, and research), DRUG INFORMATION FULL TEXT (full-text information on current and investi- gational drugs, including research, treatment, and pharmacological practice), EM- BASE (from Excerpta Medica, with references and summaries of international medical literature, covering biomedicine, health, and health care management), HEALTH, and MEDLINE. Many databases offer bibliographic citations, summaries of articles and reports, detailed financial data on companies, directory listings of companies and associations, or full-text articles and newswires; most indexed by title, subject, author, publication date. Monthly newsletter provides information on DIALOG system and databases. Electronic mail and bulletin boards available through DIALMAIL service. Compilation: Databases are compiled from journal articles, books, periodicals, patent indexes, business/company directories, newspaper articles, government documents, dissertations and theses, wire services, corporate reports. Most references are updated monthly; newspaper files are updated daily. Access: Databases are available online; accessible via modem from remote terminal through DIALNET, TYMNET, TELENET, MEADNET, IN-WATS, INFONET, DUNSNET, direct dial. Online or offline document printing available. Subscription required. Standard service plan requires no initiation fee or monthly charge; first password free for new users. Optional starter package ($ 150) includes training seminar and user guide. Connect cost includes all database royalties; varies with database searched. Several other service plan/advance purchase options available, e.g., connect cost discounts of up to $15/hour. Directory of Health Services Research Organizations Subject: Health services and policy research centers. Content: Describes more than 100 university-based health services and policy research centers, Veterans Administration health services research and demonstration field programs, and AHSR institutional members. Notes each organization's budget, pri- mary area of emphasis and expertise, staffing, training capabilities, organizational location, address, telephone number, and name of director. Highlights major research projects, funding source, and principle investigator. Indexed by subject, funding source, and principle investigators. 518

INFORMATION AND DATA RESOURCES Compilation: Information collected through mail survey and follow-up telephone interviews. Current edition of directory available early 1988. Access: Directory available upon request. Cost for AFISR members $ 10; non-members $15. DIRLINE (Directory of Information Resources Online) Source: MEDLARS Management Section, National Library of Medicine (NLM), Build- ing 38, Room 4N421, 8600 Rockville Pike, Bethesda, MD 20894, 800-638-8480, 301- 496-6193 in Maryland Subject: Public and private sector health and biomedical organizations. Content: Database contains information on over 14,000 resource centers, with special- ized information in a variety of disciplines. Also includes over 1,500 records for organizations providing information in various areas of health and disease. Contains two subfiles on specialty topics: poison control and substance abuse. Information provided for each organization includes its full name, address, contact person, and telephone number, as well as a summary of its services, activities, publications and interests. Can be searched by organization name using text words or subject-related keywords. See MEDLINE description for listing of NLM MEDLARS databases. Compilation: Information gathered from Library of Congress National Referral Cen- ter database and the ODPHP National Health Information Center database (a product of the Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services). Specialty subfiles derived from Poison Control Centers and Drug Abuse Communications Network. All records updated at least once every two years. File updated quarterly. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. Connect cost averages $22/hour peak time, $15/hour off-peak. Drug Product Problem Reporting Program (DPPR) Source: Practitioner Reporting System, United States Pharmacopeial Convention, Inc. (USP), 12601 Twinbrook Parkway, Rockville, MD 20852, 301-881-0666. DPPR sup- ported by FDA. Subject: Postmarketing surveillance of FDA-approved prescription, over-the-counter, and radiopharmaceutical drug products. 519

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Content: Database contains voluntary reports from health care practitioners on prob- lems experienced when pharmaceutical products are received, used, or dispensed; these include unsatisfactory packaging, erroneous or deficient labeling, inadequate package insert information, poor pharmaceutical quality, questionable bioavailability, stability, and therapeutic effectiveness. Reports retrievable by date report submitted, product name, manufacturer and/or type of problem. DPPR identifies trend by specific product, across product lines by drug entity, and by manufacturer. Compilation: Information gathered via toll-free telephone line or prepared reporting forms from health care professionals including physicians, nurses, pharmacists, bio- medical engineers, medical laboratory personnel, risk managers, purchasing and quali- ty assurance personnel, and consumers. Reports are entered as unverified information into FDA databases; FDA is responsible for follow up, i.e., determining manufacturer's evaluation of problem and establishing final assessment of problem. Program initiated in 1971. Updated continuously. Access: For copies of DPPR reports and product experience data, contact FDA, Freedom of Information Office, 5600 Fishers Lane, Room 12A16, HFI-31, Rockville, MD 20857, 301-443-6310. To report a drug product problem call 800-638-6725 or contact USP for reporting form. Duke Comprehensive Cancer Center Database Source: Duke Comprehensive Cancer Center (DCCC), Duke University Medical Cen- ter, Box 3153, Durham, NC 27710, 919-684-2057 Subject: Cancer cases diagnosed or treated at DCCC; designed for clinical and research oncologists. Content: Database includes epidemiological, histological, and patient demographic information such as patient medical history and history of prior cancers, state of birth, state of residency, zip code, type and stage of cancer/tumor, and treatment regimen. In addition to this comprehensive tumor registry, special registries are often established to investigate specific research questions, to examine sequelae of particular cancers, or to facilitate statistical analyses. Annual Data Management Unit Report provides statistical summaries of registry data, e.g., cancer-specific frequencies, county-specific frequen- cies, tumor-specific trends, survival rates, as well as an in-depth analysis of one or more types of cancer. Research findings also reported in medical journals and at medical conferences. Compilation: Tumor registry initiated in 1970. All living cancer patients in registry are routinely monitored; individual follow-up every 13 months. Information gathered from daily oncology clinic visits, as well as surveys designed for specific research purposes. Registry data obtained primarily from medical charts .cneri~1 re~ictriec m~v also obtain data from laboratory and pathology reports. - ~ - r ~ A ~ ~ ~ A _ ~ ~ ~ ^ ~ ~ Access: DCCC computer tapes are not in public domain due to patient confidentiality constraints. Contact DCCC Director regarding access to data resources; written re- quests indicating purpose of data acquisition and specific data required are preferred. Database search costs, if any, vary according to information requested. Searches avail- able include frequencies and survival graphs. 520

INFORMATION AND DATA RESOURCES Environmental Hazards and Health Effects Reports Source: Division of Environmental Hazards and Health Effects (DEHHE), Center for Environmental Health, Centers for Disease Control, 1600 Clifton Road, Atlanta, GA 30333, 404-454-4772 Subject: Health hazards resulting from environmental contaminants, e.g., toxic chemi- cals and radiation. Content: DEHHE databases cover disasters, environmental hazards, toxic chemicals. and other miscellaneous events. National data are collected on deaths, populations exposed to environmental toxicants, persons injured by man-made or natural disasters (e.g., nuclear or chemical disasters, hurricanes, earthquakes, tornados, etc.), variety of public health hazards, and resultant health outcomes. Reports and other publications are based on these databases. Compilation: Division activities initiated in 1984. Information gathered from individ- ual studies, surveillance systems, laboratory data of subjects in special studies, and National Medical Examiner/Coroner Survey. Reports and other publications issued on an ad hoc basis. Databases updated as necessary. Access: Reports of studies are usually available from the requesting agency within or outside CDC for which studies are done, rather than from DEHHE. Reports from DEHHE often appear in CDC Morbidity and Mortality Weekly Report and scientific journals; reprints available upon request by writing to source. Justified requests for use of databases must usually be made in writing to individual investigator, study collabora- tors, or CDC Freedom of Information Office. Environmental Health Laboratory Sciences Reports Source: Division of Environmental Health Laboratory Sciences (EHLS), Center for Environmental Health, Centers for Disease Control, Chamblee 17/1103, 1600 Clifton Road, Atlanta, GA 30333, 404-452-4152 Subject: Application of laboratory technology for the diagnosis, treatment, and pre- vention of chronic diseases and toxic chemical exposures. Content: EHLS activities include international surveillance of lipid and apolipoprotein measurements for determination of risk to coronary heart disease; international sur- veillance of toxic chemical exposure incidents (on request); and laboratory support for the National Health and Nutrition Examination Survey (HANES). Data collected on levels of dioxin and related compounds in population; cholesterol and apolipoprotein levels; exposure to and levels of polychlorinated biphenyls; cytology of cervical cancer; levels of lead, cadmium, and arsenic in the population; nutritional markers; exposure to pesticides; phenylketonuria and hypothyroidism; and biomarkers. Reports and other publications are based on these databases; also covered are descriptions of the development, validation, and evaluation of analytical methods used in surveillance activities, e.g., methods for monitoring human exposure to toxicants; responses to acute and chronic occurrences, e.g., exposures; and general epidemiological informa- t~on. 521

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Compilation: Division activities initiated in 1970. Information gathered from research and clinical laboratories; public health community studies; and national, stratified, probability sample of U.S. households (HANES data). Reports and other publications issued upon study/survey completion. Access: Reports of studies are usually available from the requesting agency within or outside CDC for which studies are done, rather than from EHLS. Reprints of journal articles written by EHLS staff and other publications available upon request by writing to source. Justified requests for use of databases must usually be made in writing to individual investigator, study collaborators, or CDC Freedom of Information Office. FDA Bulletin Board Source: Food and Drug Administration, Press Office, 5600 Fishers Lane, Parklawn Building, Room 1505, HFI-20, Rockville, MD 20857, 301-443-3285 Subject: FDA communications and meetings. Content: NEWS file contains FDA news releases covering public health and product safety issues, and some product recalls. ENFORCE file contains the weekly FDA Enforcement Report, a list of FDA-regulated products under recall; also includes seizure items, prosecution actions, injunction actions, and health fraud notices. CONSUMER file provides table of contents and selected articles from FDA's monthly magazine FDA Consumer; also covers topical updates, regulatory matters, and reports on actions by FDA investigators. APPROVALS file contains complete text of the monthly Drug and Device Products Approvals Last; includes human drug approvals, medical device approv- als, biological licenses issued, and veterinary drug approvals. DATE-REG file provides summaries of all FDA announcements made in the Federal Register arranged by publica- tion date; includes short summary of article, name of contact person, and time and place of public meetings. SUB}-REG provides summaries of all FDA Federal Re~,~ster announcements arranged by subject. BULLETIN contains the current Drug Bulletin, a newsletter useful for physicians and other health professionals. CDRH file includes the Centers for Devices and Radiological Health Bulletins that are issued monthly and contain information on recent CDRH developments and meetings. MEETINGS file covers upcoming FDA meetings announced in the Federal Register; describes time and place of meetings, topics to be discussed, and contact person. CONGRESS file contains full text of prepared statements delivered by FDA officials at congressional oversight hearings. SPEECH file provides full text of prepared speeches delivered by FDA Commissioner and Deputy Commissioner at various meetings. Keyword searching available; docu- ment can be scanned or read in its entirety. Compilation: Most items are added to bulletin board as soon as they are issued and are held for one month. Access: Available through DAILCOM 202-488-0550. Charges are $25/hour peak time and $22.30/hour off-peak, plus $0.05/kilocharacter; $25 monthly minimum. Contact Press Office for information on obtaining bulletin board documents in print form. 52?

INFORMATION AND DATA RESOURCES F-D-C Reports Source: F-D-C Reports, Inc., Suite One, 5550 Friendship Boulevard, Chevy Chase, MD 20815, 301-657-9830 Subject: Pharmaceutical product development information. Content: NDA Pipeline is a 600-page annual reference volume covering drug develop- ments during the previous calendar year. Contents include listing by company and generic name of new drug approvals (NDAs) and biological product licenses; original NDAs listed according to FDA classification system for NDAs and investigational new drug applications (INDs); index of products reviewed by FDA advisory committees; descriptions of 1,200 drug and biological products under development; articles from Prescription and OTC Pharmaceuticals; FDA drug advisory committee members and meetings; list of orphan products; and index and contact information for companies mentioned in volume. Additional F-D-C Reports include the following weekly newsletters. Prescription and OTC Pharmaceuticals covers regulatory activities, industry developments, new product introductions, and financial changes. Medical Devices, Diagnostics ~ Instrumentation Re- ports covers similar topics for the medical devices, diagnostics, and instrumentation industries. Health Policy ~ Biomedical Research covers Medicare and Medicaid, public health, health professions education and supply, federal health policy, developments concerning NIH and ADAMHA, university and industrial biomedical research, and FDA regulatory activity affecting these. Technology Reimbursement Reports covers health care reimbursement and the medical technology industry. Weekly Pharmacy Reports covers news on introduction and pricing of new pharmaceuticals, regulatory activity, lawsuits, and related developments of interest to pharmacists. Quality Control Reports, published monthly, addresses quality assurance and quality control procedures in prescription, over-the-counter pharmaceutical, cosmetics, and medical device indus- tries. Compilation: F-D-C Reports are compiled from FDA public documents, meetings, and press releases; other federal agencies such as Federal Trade Commission and Justice Department; congressional publications, hearings and other sources; health product company reports and announcements, industry and professional society conferences, . . news services, ant Investment sources. Access: F-D-C Reports may be ordered from source. Annual NDA Pipeline costs $ 175. Cost of Weekly Pharmacy Reports is $25/year; other weekly newsletters range from $260 to $470/year. Cost of Quality Control Reports is $85/year. Discounts for multiple copies. Futures Program Source: Center for Health Management Research, 1423 South Grand Avenue, Los Angeles, CA 90015, 213-742-6335. Member of American Healthcare Systems. Subject: Market trends in health care industry; intended primarily for health care management personnel. Content: Futures Program includes series of publications covering the social, techr~o- logical, environmental, economic, and political events and trends affecting health care. 523

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Forecast is an annual report on market trends and projections; recent subjects include cost-containment, intrauterine devices, laser surgery, lithotripter, long-term care, product liability, transplants. Forecast slides and scripts or videotapes also available. Health Scan assesses the impact of emerging technology and business innovations on the health care industry in terms of strategic implications for management; topics include AIDS, Alzheimer's disease, fiber optics, HMOs, marketing, technological change. Mar- ket Scan informs health care managers of new product and service opportunities; recent topics include bioethics, cardiac imaging, cardiac monitoring, cryosurgery, echocardio- graphy, gamma camera, gene therapy, home care, diagnostic imaging, interferon, interleukin-2, mammography, non-invasive technology, PPOs, perinatal services, pros- theses, recombinant DNA, tomography, ultrasound. Mini Trends covers market trends and intelligence information derived from sources not generally scanned by health care managers; recent issues include AZT, artificial kidney, bioengineering, cataracts, dialy- sis, genetic engineering, steroids. Book Digest provides synopses of management litera- ture and other select publications pertinent to health care. Compilation: Information gathered from tradejournals, periodicals, books, and other relevant literature. Active since 1980. Access: Annual subscription fee of $2,500 includes five copies of each publication mailed bimonthly. Additional subscriptions may be purchased on sliding-fee basis. HEALTH (Health Planning and Administration) Source: American Hospital Association (AMA) Resource Center, 840 North Lake Shore Drive, Chicago, IL 60611, 312-280-6263 Subject: Non-clinical aspects of health care delivery, including administration and planning of health care facilities, services and manpower; health insurance; health policy; financial management; law and regulation; personnel administration; quality assurance; licensure and accreditation; and patient education and health promotion. Content: Database includes approximately 330,000 bibliographic citations, 90 percent of which are to English language publications. Indexed using NLM's controlled vocab- ulary MeSH (Medical Subject Headings). Hospital Literature Index produced from HEALTH file. See MEDLINE description for listing of NLM MEDLARS databases. Compilation: Citations derived from MEDLINE, AHA, and National Health Planning Information Center (1975-19811. Source documents include journal articles, technical reports, government documents, theses, monographs, and monographic chapters. Approximately 3,000 citations added monthly. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. To contact MEDLARS Manage- ment Division call 800-638-8480 or 301-496-6193 in Maryland. Call source for infor- mation about Hospital Literature Idler and related information. Connect cost averages $22/hour peak time, $15/hour off-peak. Also available through BRS 800-345-4277, COLLEAGUE (BRS/Saunders) 800-468-0908, and DIALOG 800-334-2564. 524

INFORMATION AND DATA RESOURCES Health Devices Alerts Source: ECRI, 5200 Butler Pike, Plymouth Meeting, PA 19462, 215-825-6000 Subject: Problems, hazards, and recalls involving medical devices or equipment. Content: The publication reflects recalls, hazards, and problems with medical devices where these have been verified by ECRI. A typical issue of Health Devices Alerts Abstracts consists of 80 to 100 abstracts, organized by device type. Also included are presenta- tions of the problem and of the action needed, as well as a list of hospital departments that might be affected. Compilation: Information is compiled from review of more than 500 English-lan- guage medical, engineering, legal, and government publications. Health Devices Alerts was initiated in 1976. Access: Health Devices Alerts is published in two forms: Health Devices Alerts Abstracts is published twice monthly; Health Devices Alerts Action Items is published weekly. Subscrip- tions are $235/year. The database is currently on ECRI computer systems; searches are available. The database is to be available online through BMEDSS in 1988. Health Devices Sourcebook Source: ECRI, 5200 Butler Pike, Plymouth Meeting, PA 19462, 215-825-6000 Subject: Medical device nomenclature and manufacturers. Content: Cross-referenced list of more than 5,000 categories of medical devices and related products, based on ECRI numerical coding system. Each product is listed along with its U.S. and Canadian manufacturers, importers, and distributors, with contact information; a trade name section is included. Directory has references to brand-name product ratings and comparisons, and database searches made available by ECRI. Compilation: Any firm that is the manufacturer, exclusive distributor, or importer of a medical device that is sold to hospitals, either directly or through distributors or dealers qualifies for inclusion in the directory. Access: Health Devices Sourcebook published annually; 1987 edition price $140. Heady Infonnation Resources in the Federal Government Source: ODPLIP National Health Information Center (ONHIC), Office of Disease Prevention and Health Promotion, U.S. Department of Health and Human Services, PO Box 1133, Washington, DC 20013- 1133, 800-336-4797, 202-429-9091 Subject: Selected federal agencies and federally sponsored organizations with informa- tion in various areas of health and disease. 525

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Content: Information provided for each organization/resource in the directory in- cludes contact information, summary of services, activities, databases, publication topics and access information. Entries arranged alphabetically by principal keyword. Compilation: Entries selected based on r esource's ability to provide health information to health professionals and general public, and resource's existence as an office within, or a project of, the federal government. Access: 1987 directory is available from source for $2 handling fee. ONHIC database of referral organizations available online through NLM MEDLARS computer system as a component of DIRLINE. Directory provides DIRLINE record accession number for each organization to facilitate online searching. HEALTHLAWYER Source: American Hospital Association (AHA), Office of Legal Communications, 840 North Lake Shore Drive, Chicago, IL 60611, 312-280-6679 Subject: Legal and regulatory issues of health care. Content: Search capability by subject headings from thesaurus, keywords. Contains case digests, including those from Hospital Law and Health Law Digest; abstracts of articles selected from over 1 00 journals, including American f ournal of Law and Medicine, Law Medicine and Health Care, and Hospitals; full text of selected articles from newsletters such as Health Law Vigil, Hospital Ethics, and Medical Staff News, abstracts of educational conference materials. Compilation: Compiled from government reports/documents, papers presented at conferences, wire services, corporate reports, and periodicals. Database established in January 1984, updated monthly; 6,000 new records added per year. Access: Available online from BRS 800-345-4277. Connect costs $ 16 to $35/hour, plus $33 to $40 royalty. Printing costs $0.37/record online, $0.40/record offline; plus $3 to $9 telecommunication fee. Accessed through TELENET, direct dial. Subscription required. Thesaurus/search aid available to subscribers for $10. HECLINET (Health Care Literature Information Network) Source: Deutsches Institute fur Medizinische Dokumentation und Information (DIMDI), Welbhausstrasse 27, Postfach 42 05 80, D-50000 Cologne 41, Federal Repub- lic of Germany, (49-221 ~ 47-24- 1 Subject: Hospital administration, design and construction, maintenance, financing, hygiene, and economics; and non-clinical aspects of health services, including policy, economics, education, insurance, organization, planning, law, jurisdiction, and region- al planning. Content: HECLINET indexes articles from approximately 400 journals on hospital affairs and public health services; 200 journals on architecture, city planning and engineering; 20 journals on operations research; and 700 journals on economics; as well as 400 books, monographs, conference proceedings, and company publications 526

INFORMATION AND DATA RESOURCES annually. Approximately 50 percent of the articles indexed are in German; approxi- mately 30 percent are in English. 60 percent of the literature indexed in HECLINET appears in the printed version of the database, Informationsdienst Krankenhauswesenl Health Care Information Service. HECLINET's Thesaurus Krankhauswesen uses 1,100 indexing terms, available in German and English. Under new indexing system, all records will be indexed in both languages. DIMDI also provides access to U.S. National Library of Medicine databases MEDLINE, CANCERLIT, CLINPROT, HEALTH, and TOXLINE, as well as databases from other sources such as BIOSIS PREVIEWS, EMBASE (Excerpta Medica), IRCS (Else- vier International Research Communications System), MEDITEC (Medizinische Tech- nik), and SCISEARCH (Science Citation Index). Compilation: HECLINET has been compiled cooperatively since 1969 by the hospital institutes of the Federal Republic of Germany, Denmark, Sweden, Austria, and Swit- zerland. The system has a total of approximately 70,000 document records; 4,500 new records are added to HECLINET each year. The system is updated bimonthly. Access: Accessible via modem from remote terminal from DIMDI. Connection to DIMDI is possible via COMPUSERVE, DATAPAK, ITT-UDTS, TELENET, TYM- NET, WUI-DBS, RCA-LSDS, TRT and UNINET. User number codes and English language user handbook available from DIMDI. Charges for HECLINET from DIMDI include $25/year for user number code, $15/connect hour for royalties, $0.2/ printed citation, and other charges for systems time, think time, number of characters, and downloading. Some charges are reduced for non-profit users; rebates apply after 60 hours of connect time. About 65 percent of HECLINET users as German. HIAA (Health Insurance Association of America) Medical Appropr~- ateness Compilation Source: Health Insurance Association of America, 1025 Connecticut Avenue, NW, Washington, DC 20036-3998, 202-223-7837 Subject: Appropriateness of diagnostic and therapeutic medical procedures. Content: Each procedure transmittal in the Compilation includes name of procedure, definition of procedure, name of assessment program usually the Council of Medical Specialty Societies (CMSS), date submitted by HIAA to CMSS, date of opinion provid- ed by CMSS to HIAA, source of opinion (e.g., CMSS and one or more specialty societies), and opinion (most are from one sentence to one paragraph in length). In addition, the Compilation has sections on how to participate, assessment organizations, technology news, procedure listings, sources of definitions, and a topical index of procedures. Compilation: Medical appropriateness opinions in the Compilation have been generat- ed through an arrangement initiated in 1977 between HIAA and the CMSS. HIAA has accepted requests for opinions from its member companies and forwarded these to CMSS (specifically, its Program for Clinical Procedure Review), which distributed them to one or more of its 24 respective specialty societies, as appropriate. When the specialty societies rendered opinions to CMSS, these have been forwarded to HIAA for distribu- tion. A few opinions have been used from other assessment sources. Since 1985, these 527

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY opinions, referred to as procedure transmittals, have been organized in the loose-leaf Compilation, which is updated approximately annually. Since 1978, CMSS has returned opinions on 115 of approximately 200 HIAA requests. The CMSS is reviewing and considering revisions to its clinical procedures review process and related technolo~v . . . assessment activities. Access: The Compilation is available from HIAA for $25. High Blood Pressure Information Center . An, Source: Office of Prevention, Education, and Control, National Heart, Lung, and Blood Institute (NHLBI), 120/80 National Institutes of Health, Bethesda, MD 20892, 30 1-496- 1 809 Subject: High blood pressure and prevention of hypertension-related death and dis- ability. Content: Bibliographic database provides citations to over 6,000 journal articles per- taining to hypertension, cardiovascular disease risk factors, and related topics. Infor- mation resources cover consumer and professional health education interventions for control and detection of high blood pressure (HBP), materials and guides on planning, implementing, and evaluating HBE control programs, guidelines for detection, diag- nosis, and treatment of HBP, recommendations on the roles of health care providers in HBl? control, catalogs of audiovisual and printed educational materials, and ongoing community and state activities in HBP control. Center maintains information on research, funding, and principal investigators in hypertension and assists in referrals to appropriate sources of research information. Other services: preparation of custom- ized information packets containing journal reprints, resource materials on current topics of interest and relevant publications, literature searches, and technical assistance for program planning or workshop development. Publishes quarterly newsletter fea- turing ongoing projects and activities. Compilation: Information gathered from medical and professional journals, National Health and Nutrition Examination Survey, Health Interview Survey, National Center for Health Statistics reports, NHLBI demonstration and education projects, NHLBI research grants, state and local health departments, voluntary health agencies, pharma- ceutical company publications, and member organizations on National High Blood Pressure Education Program Coordinating Council. Database updated monthly. Ac- tive since 1972. Access: Publications list available upon request. All services and materials are free of charge; however, materials available in limited quantities. Database is available online through BRS 800-345-4277, and is also part of the Combined Health Information Database (CHID). Database indexed by keywords; thesaurus available to users. IMPAC Conformation for Management Planning Analysis and Coor(lination) Source: Statistics and Analysis Branch, Division of Research Grants (DRG), National Institutes of Health, Bethesda, MD 20892, 301-496-7543 528

INFORMATION AND DATA RESOURCES Subject: Administrative information on reviews and awards for extramural research programs of NIH, ADAMHA, and other PHS programs. Content: The IMPAC Pending and Open Master Files include master records of basic data on NIH extramural programs. The Institutional Profile File is used to retrieve institution-specific information. The Project Address File is used to retrieve address and related information for Notices of Grant Award. The Trainee Appointment File contains information on NIH, ADAMHA, and CDC training grant programs. The Committee Management Information System includes information on NIH public advisory committees. The National Research Service Award (NRSA) Payback File contains information on fellows and trainees who have incurred a payback obligation under a National Research Service Award. Compilation: Much of IMPAC data is compiled from the approximately 50,000 com- peting and noncompeting applications for PHS extramural support processed through the system annually; data are updated continuously during the review and award process and with feedback from recipients of IMPAC output. Each week, administra- tive data from IMPAC are transferred to CRISP (a related system dealing with scientific aspects of extramural and intramural research supported by PHS; see CRISP descrip- tion). Access: IMPAC is designed primarily for access by DHUS staff. DRG offers a variety of IMPAC services to D8HS users, including an extensive query software system. Speci- f~ed data sets on magnetic tape are provided to most PHS awarding agencies. A variety of reports on active grants and training awards are provided in hard copy, magnetic tapes, and microfiche. DRG provides publications generated from IMPAC on trends in extramural research, characteristics of NIH public advisory committees and peer review of grant applications, and related information. IMS Audits Source: IMS America Ltd., 660 West Germantown Pike, PO Box 905, Plymouth Meeting, PA 19462-0905, 215-834-5000 Subject: Sales and market research on health care products. Content: Data provided on prescription, distribution, promotion, and sale of pharma- ceuticals; purchase of hospital supplies; patterns of diagnosis and treatment of disease. Among the audits provided by IMS are the following. U.S. Pharmaceutical Market- Hospitals reports hospital purchases of pharmaceuticals and diagnostics, including a monthly report of new drugs on clinical trial. Hospital Supply Index reports on hospital purchases of medical/surgical supplies. New Product Digest covers new products and their progress in the market. LabList audits census information on laboratory instru- mentation and equipment in clinical laboratories. GrouPractice Market: Instrumentation and Testing audits census data on instrumentation in physician group practices. Clinical Laboratory Audit, based on survey data from the College of American Pathologists, covers test volume and brand share for clinical laboratory tests. National Disease and Therapeutic Index covers data on patterns and treatment of disease encountered in medical practice. Other audits cover circulation and cost of pharmaceutical advertising, sales of pharmaceuticals and diagnostic reagents, and prescribing activities of individ- ual physicians. Data from these audits may be customized in a variety of formats. 529

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY IMSPACT is an online system for access to the complete IMS pharmaceutical database, including data on drugstore, hospital, physician, and promotional activities in the U.S. Compilation: IMS collects census or sample data from 27,000 anonymous sources in U.S. and Canada, including drugstores, hospitals, physicians, and laboratories. Access: Data are accessible on a contractual basis through remote online terminals, printed matter, and microfilm. Charges vary depending upon choice of audit and the amount of data required. For instance, charges for LabList may range from approxi- mately $2,600 for smaller portions of the audit, to approximately $93,000 for the entire audit. The charge for the 12- 14 volume annual LabFile from the LabList is approximate- ly $25,000. Charges for Clinical Laboratory Audit may range from $1,000 for certain portions to $36,000 for the entire audit. IMSPACT iS accessible online for subscribers to printed IMS audits. The charge for online access to the complete set of files in IMSPACT iS approximately $94,000, plus computer charges. When approved by IMS, certain data sets may be accessible at reduced or no charges to university or other researchers for non-commercial purposes. International Market Research Studies Source: Division of Market Analysis, Office of Commercial Information Management, Room 2012, U.S. Department of Commerce, 14th Street and Constitution Avenue, NW, Washington, DC 20230, 202-377-4203 Subject: Export market information for many U.S. industries, including medical equipment and supplies and health care service industries. Content: International Market Research Studies analyze market size, trends, competition, distribution channels, competition, distribution channels, business practices, barriers, and other market factors for an industry in a selected country. Studies on medical equipment and/or health care services were concl~cter1 for ~nnro~xim~t`>lv in rm,~ntri~c during the period 1982- 1987. ~ ~_ 1 _._ ~it ~ or AN ) ~4~-~ ~ompllallon: 1vlaJorlty ot reports conducted using Commerce .snerifi~:ationc Or _~ :~. . ~1 1~_ ~ ~ ~_C _ ~1 . O ~ ~ ~ _ a, A,, ~ _, ~ ~ Us ~ By up.. masses to consultants in respective countries. Special Situation Reports generally conducted by U.S. and Foreign Commercial Service and/or embassies. Access: Print copies formerly available from U.S. Department of Commerce. During 1987, information for all studies was loaded on new U.S. Department of Commerce computer system CIMS (Commercial Information Management System). Tailored reports of varying lengths may be printed for set-up fee (e.g., $15) and per-page fee (e.g., $2~. Computer files not directly accessible to public. Some back reports are available from local district and regional Commerce offices for approximately $100. More than 80 new reports reviewed during 1987 to be placed directly onto CIMS. Related reports include Export Statistics Profiles, Export Overviews, and Special Situation Reports. Country Market Surveys and Annual Worldwide Industry Reviews no longer pro- duced, though back issues may be available in district offices. 53O

INFORMATION AND DATA RESOURCES INTERNIST-1/QUICK MEDICAL REFERENCE (QMR) Source: Section of Medical Informatics, Department of Medicine, 190 Lothrop Street #165A, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, 412-648- 3190 Subject: Diseases in internal medicine; designed as diagnostic consultant system for health care professionals. Content: Information organized in disease profiles, a list containing an average of 85 findings per disease. Findings include demographic data, predisposing factors, patient symptoms, signs, and laboratory abnormalities. Knowledge base describes 573 diag- noses, recognizes 4,100 patient findings, and includes more than 4,000 links detailing causal, temporal, and probable interrelationships among disorders. Approximately 250,000 medical facts and other items of information are included in the knowledge base. QMR augments INTERNIST- 1 capabilities, allows direct access to information in knowledge base, provides users with multiple ways of reviewing and manipulating diagnostic information, and assists users with generating hypotheses in complex patient cases. Compilation: INTERNIST-1 developed in 1973; successor program QMR developed in 1985. Data about a disease or clinical syndrome and its diagnosis derived primarily from two sources: review of medical literature, including general and subspecialty textbooks, monographs, and approximately 50-100 relevant primary journal articles; and debriefing medical experts, i.e., gathering information about their factual and heuristic knowledge of a given disease. Knowledge base updated weekly. Several publications appear annually describing progress in further refining Program ca~abili- ties and related research activities. <A 1 ~ Access: Computer programs run on IBM-PC-AT compatible microcomputers. Knowl- edge base is copyrighted and proprietary to the University of Pittsburgh; contact directly for further information. Several articles describing knowledge base and related research activities have appeared in medical and professional journals; reprints avail- able upon request. Market Research Reports Source: Theta Corporation, Theta Building, Middlefield, CT 06455, 203-349-1054 Subject: Market analysis/research on health care, biotechnology, pharmaceuticals, ana- lytical instruments; intended primarily for medical device manufacturers. Content: Reports cover specific markets, including description and analysis of technol- ogy, review of other technologies in field, evaluation of competitors, current market assessment, market trends and projections. Reports generally include executive sum- mary, technology, market factors, market size, market shares, and company profiles. Recent topics include electrophoresis, spectroscopy, DNA synthesizers, monoclonal antibodies, endoscopy, diagnostic imaging equipment, fetal monitoring, cardiac moni- toring, medical ultrasound, arthroscopy surgical systems, lithotripsy, cryosurgery equipment, kidney dialysis supplies and equipment, contraceptive devices, and dental equipment. Monthly newsletter Changing Medical Markets covers business/finance, med 531

MEDICAL TECHNOLOGY ASSESSMENT DfRECTORY ical products, premarket approvals, recalls and patents, new technology, sales and acquisitions, management changes, publications/journals, the courts, and meetings. 1986 Med Tech Directory profiles 800 publicly owned health care companies. MPA Healthcare Distributor Guide describes product distributor selection. Compilation: Information gathered from industry personnel, trade journals, govern- ment publications, annual reports, trade shows, conferences. Active since 1968. Access: Free catalog, report table of contents, and sample newsletter available upon request. Report prices range from $300 to $900. Newsletter subscriptions $ 195/year or $325/two years. 1986 Med Tech Directory price $150. MPA Healthcare Distributor Guide price $495. Market/Technology Reports Source: Biomedical Business International, 17722 Irvine Boulevard, Tustin, CA 92680, 714-838-8350 Subject: Market research on health care products and services. (Jontent: Three major types of reports are MarketlTechnology Reports (ranging from 40 to 500 pages in length) covering current markets, technologies, competition and envi- ronmental factors, and market forecasts; Strategic Marketing Studies (~)-2.2~O now 7 ~_ ~t~ In V V ~is . . . covering marketing and sales approaches; and Conference Proceedings (86-183 pages). Major subject areas for reports are anesthesiology, biomaterials, cardiovascular prod- ucts, catheters, clinical testing, critical care/monitoring, dentistry, disposables, drugs and drug delivery, extracorporeal therapy, HMOs/alternate site services, fertility con- trol, hematology, home health/self care, imaging, information management, IV fluids/ nutrition, neurology, ob/gyn/perinatology, oncology, ophthalmology, orthopedics/ trauma, respiratory therapy, and surgery. Newsletters include: Rinmedical ~q`.cinP~cc International (20 issues/year) covers market segments, companies and business issues, new technologies: Worldwide Medical Mr7rkr~t.c (441v`~r) rOv`~rc int~rn~ti~n~1 no sales opportunities; Healthcare Marketing (12/year); Medical Product Development (12/ years. Directories on genetic engineering and biotech firms, biotech firms medical products of Japan, West Germany Directory of Medical Devices, and U.K. Health Service Buyers Guide. Healthcare Technology Transfer and Product Opportunities directory covers descriptions and contact information for technologies available for purchase, license, or distribution. Other reports cover international regulations for health care products, and market research reports for specific countries. Arranges approximately 20 conferences annually, usually in conjunction with professional society meetings. Compilation: Information gathered from interviews of health care providers and industry personnel, trade journals, government publications, annual and quarterly company reports, conferences, press contacts, literature searches. Access: Free catalog, sample newsletters, tables of contents for Market Technology Reports, Strategic Marketing Studies, Conference Proceedings, and directories available upon request. Market/Technology Reports prices range from $450 to $2,900, newsletters $275-$695, conference report proceedings $100-$700, product and firm directories $80-$195, Healthcare Technology Transfer and Product Opportunities directory $775 plus monthly updates. Customized information services also available. 532

INFORMATION AND DATA RESOURCES Medical Device and Laboratory Product Problem Reporting Program (PRP) Source: Practitioner Reporting System, United States Pharmacopeial Convention, Inc., 12601 Twinbrook Parkway, Rockville, MD 20852, 301-881-0666. PRP supported by FDA Center for Devices and Radiological Health. Subject: Postmarketing surveillance of FDA-approved medical and radiological health devices and laboratory products. Content: Computerized database contains voluntary reports from health care practi- tioners on problems experienced with medical or lab products such as improper labeling, design problems, defective components, performance failures, poor packag- ing, incomplete or confusing instructions, and erroneous information. Products cov- ered include intravenous pumps, catheters, in vitro diagnostic reagents and kits, cardi- ac and respiratory monitors, ultrasound and X-ray equipment. Reports retrievable by date report submitted, product name, manufacturer and/or type of problem. PRP identifies industry-wide problems or trends and highlights specific product problems. Compilation: Information gathered via toll-free telephone line or reporting forms from health care professionals including physicians, nurses, pharmacists, biomedical engineers, medical laboratory personnel, risk managers, purchasing and quality assur- ance personnel, and consumers. PRP reports are used to compile the Device Experi- ence Network (DEN) files for FDA. Reports are submitted as unverified information to FDA, which is responsible for follow up, i.e., determining manufacturer's evaluation of problem and establishing final assessment of problem. Program initiated in 1973. Updated continuously. Access: PRP reports are included in DEN reports accessible through BMEDSS 216- 375-3501, National Technical Information Service 703-487-4630, Medical Device Reg- ister's Product SOS 203-348-6319, and ECRI 215-825-6000. Confidential trade, com- mercial, financial, personnel, medical, and patient information are deleted from pub- licly available reports. DEN reports in microfiche and additional information about specific reports available from FDA, Freedom of Information Office, Room 12A16, HFI-31, 5600 Fishers Lane, Rockville, MD 20857, 301-443-6310. Monthly publication Device Experience Network Reports, which includes PRP but not Medical Device Reporting information, is available from FOI Services, Inc., 301-881-0410 for $190. To report a device problem call U.S. Pharmacopeial Convention 800-638-6725 or contact USP for reporting form. Medical Device Register Source: Medical Device Register, Inc., 655 Washington Boulevard, Stamford, CT 06901, 800-222-3045, 203-348-6319 Subject: Medical devices, equipment, and supplies; includes manufacturers and dis- tributors. Content: Volume 1 covers over 8,000 manufacturers and 13,000 distributors in U.S. and Canada, with data on company size, ownership, key executives, financial status, distri- bution method, and product line. Products are organized into 6,000 FDA categories; 533

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY includes definitions and product descriptions, as well as comparison of prices and specifications for competing products. Volume 1 contains keyword index, device infor- mation, and trade name index. Volume 2 covers over 3,000 manufacturers and 3,300 distributors located outside the U.S. and Canada. Both volumes are divided into four sections: directory of products, supplier profiles, supplier geographical index, and directory of local dealers. Bimonthly newsletter Supplier Hotlast profiles new companies and their products added to MDR database during previous two-month period. Catalog Library Service consists of catalogs on microfiche of 2,000 medical product manufactur- ers. Distributor Profiles contains company descriptions and contact information. Public Company Profiles highlights the 500 publicly owned companies covered in Medical Device Ret ster. Compilation: Information is gathered primarily from product manufacturers and distributors, as well as news releases, reports from various other sources, including FDA. Database is updated daily; approximately 3,000 manufacturers and distributors added annually. Publications are issued annually. Active since 1981. Access: Charge for Medical Device Register Volume 1 (1987) is $150; charge for Medical Device Register Volume 2 (1987) is $120. Charge for computer tapes is $400 for set up plus $400/1,000 companies, or $6,800 for all companies; floppy disks also available. Medical Device Register information is to be available online through DIALOG in 1988. Supplier Titlist subscription $125/year. Brochure and price list available upon request. Medical Device Reporting (MDR) Source: Division of Product Surveillance, Office of Compliance, Center for Devices and Radiological Health, HFZ-343, Food and Drug Administration, 8757 Georgia Avenue, Silver Spring, MD 20910, 301 -427-8100 Subject: Postmarketing surveillance of medical devices and in vitro diagnostic prod- ucts. Content: Medical Device Reporting regulation ~ 1984) requires that manufacturers and importers of medical and diagnostic products report to FDA any information that suggests one of their devices may have caused or contributed to a death or serious injury, or has malfunctioned and, if such malfunction recurs, is likely to cause or contribute to death or serious injury. MDR database contains reports from manufac- turers and importers pertaining to device performance failures and/or malfunctions that have resulted in injury, death, or any hazard to safety. Compilation: Information reported to FDA is gathered from physicians nurses, pa- tients, consumers,and hospitals; medical and scientific literature; and from independ- ent research, testing, evaluation, servicing, or maintenance of devices by the manufac- turer. Program established in 1984. Updated continuously. Access: MDR reports are included in DEN reports accessible through BMEDSS 216- 375-3501, National Technical Information Service 703-487-4630, Medical Device Reg- ister'sProductSOS 203-348-6319, and ECRI 215-825-6000; and are available from the BPS/SEARCH database DIOGENES. Confidential trade, commercial, financial, per- sonnel, medical, and patient information are deleted from publicly available reports. 534

INEORMATION AND DATA RESOURCES DEN reports in microfiche and additional information about specific reports available from FDA, Freedom of Information Office, Room 12A 16, HFI-31, 5600 Fishers Lane, Rockville, MD 20857, 301-443-6310. MEDIS Source: Mead Data Central, PO Box 933, Dayton, OH 45401,800-227-4908,513-865- 6800 Subject: Medicine, drugs, health care, pediatrics, psychology. Content: MEDIS service is divided into the following files: GENMED, PHARM, CAN- CER, MEDLINE, and ADMIN. Provides full text of more than 60 clinical journals, newsletters, and textbooks covering a broad range of medical topics. Covers publica- tions of American Medical Association, American Society of Hospital Pharmacists, American Health Consultants, and F-D-C Reports. Also includes PDQ and MEDLINE. Full-text searching capability by subject. Electronic clipping service ECLIPSE automati- cally repeats stored MEDIS searches. Compilation: Compiled from journal articles, monographs, books, and newsletters. Updates vary with publication. Access: Database available online from remote terminal. Connect cost is $30/hour including telecommunication cost. Search charge is $3 to $ 13/search during peak time; 30 percent discount for off-peak. Accessed through MEADNET, TELENET, direct dial. Subscription required, fee for physicians $50/month, includes access to NEXIS. Different price structure available for hospitals and medical groups. MEDLINE Source: MEDLARS Management Section, National Library of Medicine (NLM), Build- ing 38, Room 4N421, 8600 Rockville Pike, Bethesda, MD 20894, 800-638-8480, 301- 496-6193 in Maryland Subject: Medicine, biomedicine, health care. Content: Database includes bibliographic citations to over 5 million articles from ap- proximately 3,200 biomedical journals published in the U.S. and abroad. Contains all citations published in Index Medicus, as well as citations found in International Nursing Index and Index to Dental Literature. Citations include English abstracts, if published with article. Indexed using NLM controlled vocabulary MeSH. Published literature searches on selected topics available from NLM, including, e.g., percutaneous ultrasonic litho- tripsy, adjuvant chemotherapy for breast cancer, therapeutic plasmapheresis in neuro- logical disorders, surgical treatment of morbid obesity, peer review organizations, HMOs, and indigent care. Also available are brochure and fact sheets covering online services, specialized information sources, and extramural programs; and online serv . . . ices training courses. Other databases provided by MEDLARS that are described in this section include BIOETHICSLINE, CANCERLIT, CLINPROT, DIRLINE (Directory of Information Resources Online), HEALTH (Health Planning and Administration), PDQ (Physician 535

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Data Query), and POPLINE (Population Information Online). Additional databases provided by MEDLARS are AVLINE (Audiovisuals Online), CATLINE (book Catalog Online), CHEMLINE (Chemical Dictionary Online), HISTLINE (History of Medicine Online), MeSH VOCABULARY FILE, NAME AUTHORITY FILE, RTECS (Regis- try of Toxic Effects of Chemical Substances), SERLINE (Serials Online), and TOX- LINE (Toxicology Information Online). Compilation: Compiled primarily from journal articles and selected chapters and articles from monographs. Coverage from 1966 to present. Updated monthly with approximately 25,000 citations. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. Connect cost averages $22/hour peak time, $15/hour off-peak. Also available through BRS 800-345-4277, COL- LEAGUE (BRS/Saunders) 800-468-0908, DIALOG 800-334-2564, MEDIS (Mead Data Central) 800-227-4908, and PAPERCHASE (Beth Israel Hospital) 617-735-2253 in Massachusetts, 800-722-2075 elsewhere. NLM Publications available upon request; provides current ordering information, titles, and prices for NLM publications. Online Services Reference Manual, 1986 ($46) and Basics of Searching MEDLINE: A Guide for the Health Professional ($12) available from NTIS 703-487-4650. GRATEFUL MED is a software package on two floppy disks for facilitating online searching and search downloading of MEDLINE, CATLINE. CHEMLINE. DIR- LINE, HEALTH, TOXLINE, and other MEDLARS databases. Contact MEDLARS Management for additional information. GRATEFUL MED can be ordered for $29.95 plus $3 for shipping from NTIS 703-487-4650. MEDLINK (Massachusetts Medical Information Link) Source: PO Box 9080, Waltham, MA 02254-9080, 800-342-1338, 617-890-0385 in Massachusetts. Directed by the Publishing Operation of the Massachusetts Medical Society. Subject: Electronic mail and interlibrary loan networking service. Content: Information services such as document delivery, literature searching, topic bibliographies, newsletters. Information sources available on the network include newswires and EASYNET, a service linking many databases including MEDLINE and HEALTH. Network also offers general use electronic mail, bulletin boards, online directory of subscribers, access to American Library Association's ALANET electronic information service. Provides network services for groups seeking to establish their own subnetworks. Training classes available for searching MEDLINE, BPS/COLLEAGUE, and PAPERCHASE. Compilation: Network links approximately 80 Massachusetts health science libraries and five out-of-state resource libraries, including the National Library of Medicine and its regional medical library at the New York Academy of Sciences. Began operations in 1985. 536

INFORMATION AND DATA RESOURCES Access: Accessible via modem from remote terminal. One-time registration fee ($50) includes three user IDs, set-up, and introductory materials. Registration fee for each additional user $5. Annual service fee $100/year; statistics fee $85/year. Connect time $18/hour peak time; $14/hour off-peak. Surcharges for newswires, bulletin board, gateway to other databases, text storage, and training classes. Multi-Client Reports Source: International Resource Development, Inc., 6 Prowitt Street, Norwalk, CT 06855, 203-866-7800 Subject: Market analysis/research reports on biotechnology, medical devices and sys- tems, telecommunications, consumer electronics, financial services, personal comput- ers, robotics, electro-optics. Content: Reports cover international high-technology industries and markets, includ- ing the development of selected industries and companies, critical trends and technol- ogies, and 10-year growth projections. Reports normally include: executive summary, background description of the field, market segments, market analysis, market assess- ment, market forecasts, and company profiles. Recent report topics include biotechnol- ogy equipment and supplies, prostheses for sensory and internal organs, European medical imaging equipment markets, impact of biotechnology on specialty chemicals and pharmaceutical markets, high-tech drug delivery systems, laser market opportuni- ties, emerging membrane separation technologies. Publishes several newsletters on software distribution technologies, electronic mail and micro systems, telecommunica- tions equipment and services, and electronic home information. Compilation: Information derived from interviews with industry personnel, industry data, current publications, reports, and other relevant literature. Approximately 50 studies conducted annually, five to ten of which are in the biotechnology and life sciences field. Active since 1971. Access: Free catalog of publications available upon request. Report prices range from $900 to $2,500. Newsletter subscriptions $260 to $375/year. NAHDO Resource Manual Source: National Association of Health Data Organizations (NAHDO), 316 Pennsylva- nia Avenue, SE, Suite 202, Washington, DC 20003, 202-546-5881 Subject: Compendium of information regarding statewide health data organizations. Intended audience includes state governments, health services researchers, health insurers, consulting firms. Content: Contents arranged by state. Included are copies of legislation and regulations authorizing data collection, analysis and dissemination; data dictionaries for financial and discharge databases; documentation of sources of data used, e.g., providers or third parties; description of data system software and hardware; descriptions of coding systems; standard report formats; procedures for requesting data and reports; plan or procedure for report dissemination; and budget and staffing information. 537

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Compilation: State health data organizations submit information and data annually to NAHDO for compilation of manual. Access: First edition available early 1988; price to be determined. National Center for Health Statistics Publications and Data Source: Scientific Information Branch, Division of Data Services, National Center for Health Statistics (NCHS), 3700 East-West Highway, Hyattsville, MD 20782, 301-436- 8500 Subject: Vital and health statistics for the U.S. Content: Public use data tapes include: Vital Statistics (nasality, mortality, marriage, divorce, other vital events); National Health and Nutrition Examination Survey (dis- ease prevalence, normative ranges for physiological and body measurements, and nutritional status); National Health Interview Survey (extent of illness and disability in the population); National Survey of Family Growth (contraception, reproduction, family formation and dissolution); National Hospital Discharge Survey, National Am- bulatory Medical Care Survey, National Nursing Home Survey (supply and utilization of health resources/services); National Master Facility Inventory (inpatient health facili- ties); National Inventory of Family Planning Services (facilities providing medical and nonmedical family planning services); National Medical Utilization and Expenditure Survey (costs of illness and health care expenditures). Data from surveys and studies are presented in a variety of publications, including the Vital and Health Statastics series, Advance Data from Vital and Health Statastics, Vital Statastics of the U.S., Monthly Vital Statistics Report, Statistical Notes for Health Planners, and selected articles published in medical and scientific journals. Public use data tapes and unpub- lished tabulations are also available. NCHS provides technical assistance through con- ferences, seminars, workshops, and individual consultations to foster and improve health statistics analysis and use. Compilation: Data obtained from several statistical data collection systems: national vital registration system, surveys based on samples of birth and death records, continu- ing nationwide interview survey of households, series of national surveys in which physical examinations are conducted on samples of populations, periodic surveys of institutions and their patients, continuous national sampling of short-stay hospital records, and surveys of various categories of health manpower. Reports cover monthly, annual, and periodic data collection activities. Active since 1960. Access: Catalog of NCHS publications available upon request. Catalog provides list of free reports, order form, prices, and instructions for purchasing reports from U.S. Government Printing Office 202-783-3238; publications indexed by major health topics. Catalog providing availability and price information on NCHS public use data tapes available upon request. Public use data tapes sold through NTIS 703-487-4650. Data Tape Update provides current information on data tapes and prices. 538

INFORMATION AND DATA RESOURCES National Cholesterol Education Program (NCEP)/NHLB} Smoking Education Program (NSEP) Information Center Source: Office of Prevention, Education, and Control, National Heart, Lung, and Blood Institute (NHLBI), Building 31, Room 4A-21, National Institutes of Health, Bethesda, MD 20892, 301-230-1340 Subject: Health effects of cholesterol and smoking; prevention of coronary heart disease and chronic obstructive pulmonary disease. Content: Publications cover arteriosclerosis, heart disease, management strategies for detection and treatment of persons with high blood cholesterol levels, consensus state- ments concerning high blood cholesterol, counseling techniques and consumer educa- tion sheets, cardiovascular disease risk factors, materials for work-site heart disease risk reduction programs, physician continuing medical education materials related to cho- lesterol and smoking, primary care physician's role in promoting smoking cessation, and suggestions for public, professional, and patient education. NCEP publications list is organized alphabetically by title and annotated; NSEP resource list is annotated and divided into professional and patient education resources. Center is developing a database on smoking and cholesterol programmatic materials, including curriculum guides and other educational materials, descriptions or evaluations of specific pro- grams, directories and bibliographies, relevant laws and legislation. Compilation: Information gathered from NHLBI-sponsored research and working groups, expert panels, results of biomedical, epidemiological and health behavior studies. Active since 1985. Access: Current NCEP publications list and NSEP resource list available upon request. Single copies of publications available free of charge. NCEP/NSEP Information Center database not yet publicly available; however, planning is underway to make it available through BRS 800-345-4277, as part of the Combined Health Information Database (CHID). National Reference File Source: Health Data Institute (HDI) (subsidiary of Caremark, Inc.), 20 Maguire Road, Lexington, MA 02173, 617-863-2000 Subject: Compilation of national normative statistics on health care utilization and cost trends and patterns of care. Content: Database contains information provided by client organizations' employee health insurance claims data. Clients include major corporations, unions, commercial insurance companies, and Blue Cross and Blue Shield plans, as well as state and federal health care providers. The file provides data by population subgroup, region of the country, industry, diagnosis or provider or other information relevant to the location of care (inpatient, outpatient, office), length of stay, appropriateness of care, average cost per service, and utilization rates. 539

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Compilation: All clients of HDI Claims Data Analysis Division are asked to add their claims data to the national database. HDI edits and merges all relevant data into the National Reference File. Access: HDI clients who provide data into National Reference File (N RF) can get comparative statistics included with other HDI analytic reports. Clients who have no data to provide are charged a fee based on data requested. HDI plans to publish normative descriptive statistics and trends in a subscription series format in late 1987. National Technical Information Service Publications and Data Source: National Technical Information Service, U.S. Department of Commerce, 5285 Port Royal Road, Springfield, VA 22161, 703-487-4650 Subject: Among the subject categories of the NTIS information classification system are biomedical technology and human factors engineering; computers, control, and information theory; government inventions for licensing; health planning and health services research; library and information sciences; and medicine and biology. Content: NTIS BIBLIOGRAPHIC DATABASE has bibliographic summaries of NTIS reports. 1986 Published Search Catalog provides bibliographic citations of NTIS reports in such areas as diagnostic agents, health care costs, health information systems, health insurance, HMOs, mechanical organs, medical computer applications, medical equipment, and medical imaging. Among weekly NTIS abstract newsletters covering new entries to NTIS collection are Biomedical Technology ~ Human Factors Engineering, Health Planning ~ Health Services Research, Government Inventions for Licensing, and Medicine ~ Biology. FEDRIP (Federal Research in Progress) database provides bibliog- raphy of ongoing federally funded research projects, including NIH, VA, other sources. NTIS provides data files from such agencies as NCHS (health and vital statistics), NCHSR (hospital care, home care, national medical expenditures, HMOs, services to the elderly), and FDA (summary reports of newly approved medical products, national drug code directory). Monthly Tech Notes provides fact sheets on new applied technol- ogy and R&D results in medicine and biology and other fields; these are compiled by subject in Federal Technology Catalogs. Other products are Directory of Federal Laboratory Technology Resources and Government Reports Annual Index. Compilation: NTIS holdings are compiled from scientific, technical, engineering, and business studies sponsored by the U.S. government and international sources. Among the federal sources are CDC, DOD, EPA, FDA, NASA, NCHS, NCHSR, NIH, NLM, USDA, and VA. NTIS BIBLIOGRAPHIC DATABASE includes 1.2 million records, increased by 70,000/year. Collection contains 350,000 technical reports from other countries. Access: NTIS information is available in technical reports, software, data files, data- bases, abstract newsletters, published searches, and other formats. Guide to NTIS bro- chure provides overview to resources and access information. Charges for printed reports generally cover the cost of duplication plus $3 handling fee. Annual subscrip- tion charges range from $79 to $205 for weekly abstract newsletters, $ 127 for monthly Tech Notes. NTIS BIBLIOGRAPHIC DATABASE is available through DIALOG 800- 227-1960, SDC Search Services 800-421-7229, and Bibliographic Retrieval Services 54O

INFORMATION AND DATA RESOURCES 800-833-4707. Database search help is available at no charge from NTIS 703-487- 4640; call 703-487-4929 for international access information. NTIS sales desk 703-487- 4650; for rush orders call 800-336-4700, 703-487-4700 in Virginia. NEXIS Source: Mead Data Central, PO Box 933, Dayton, OH 45401,800-227-4908,513-865- 6800 Subject: General reference, business and industry, marketing, finance, science, tech- nology. Content: NEXIS service includes the following library files: NEXIS, ASAP II, ENCY- LOPAEDIA BRITANNICA, GOVERNMENT DOCUMENTS, INFORMATION BANK, and U.S. PATENT AND TRADEMARK OFFICE. Files cover more than 160 newspapers, magazines, wire services, newsletters, trade and professional journals in full text. Files organized by publication type and subject. Full-text searching capability by subject. Compilation: Compiled from journal articles, government reports/documents, pub- lished proceedings, theses and dissertations, news releases, broadcasts, security analysts' reports. Updates vary with publication; daily for newspapers. Access: Database available online via modem from remote terminal. Connect cost: $30/ hour including telecommunication cost, plus $7 peak time search charge for individual files; 30 percent discount for off-peak. Accessed through MEADNET, TELENET, direct dial. Document delivery through NEXIS mail service, offline or online printers. Subscription fee is $50/month. Contact producer for one-time installation charge and monthly charges. Free user manual and database documentation available to subscrib- ers. National Heart, Lung, and Blood Institute Publications Source: Communications and Public Information Branch, National Heart, Lung, and Blood Institute (NHLBI), Building 31, Room 4A-21, National Institutes of Health, Bethesda, MD 20892, 301-496-5343 Subject: Causes, detection, treatment, and prevention of heart, lung, and blood disease and management of blood resources. Content: Publications cover summaries of NHLBI-sponsored working groups; state- of-the-art assessments; recommendations for future research; annual Institute Direc- tor's reports; NHLBI Advisory Council reports; and health education, community intervention, and medical intervention strategies for control of high blood pressure, high blood cholesterol, and smoking cessation Pllblic~tionc or~ni7~H hv NUT RT programmatic area and subject. ~_ ~) ~ ~,&. ~I - ~ ~ Compilation: Publications prepared by NHLBI Office of Prevention, Education, and Control (OPEC). Information gathered from studies supported by NHLBI, working groups or conferences sponsored by NHLBI, programmatic materials developed by NHLBI or by NHLBI-supported researchers, and OPEC's three cardiovascular dis 541

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY ease/chronic obstructive pulmonary disease risk factor reduction programs: National High Blood Pressure Education Program, National Cholesterol Education Program, and NHLBI Smoking Education Program. Publications list updated annually. NHLBI activities initiated in 1948; Office of Prevention, Education, and Control created in 1972. Access: Current listing of publications available upon request. Many publications are free, however, supplies are limited. Oxford Database of Postnatal Trials Source: National Perinatal Epidemiology Unit, Radcliffe Infirmary, Oxford OX2 SHE, England, (44-865) 81-68-76. Research sponsored by Department of Health and Social Services and Oxford University Press. Subject: Perinatal medicine Content: Database provides bibliographic citations to, evaluation of, and analyses based on more than 3,000 reports of randomized controlled trials in perinatal medicine conducted in approximately 57 countries. Includes data derived from meta-analyses of subject-specific subgroups of trials, as well as information on unpublished, ongoing, and planned trials. Reports are classified according to stage of perinatal period covered in trial, entry characteristics and total number of participants, intervention, outcome, methods of treatment allocation, number of treatment groups; also indexed by author, title, journal, year of publication, country, title keyword, and subject. Records may be accessed using any of above categories alone or in combination. Compilation: Database has been compiled since 1978 from articles in obstetric, pediat- ric, and other medical journals, MEDLINE searches, lists of citations used in reviews and other reports of research, conference reports and abstracts, correspondence, and informal meetings. Coverage from 1940 to present; updated daily. Access: Database on computer disk, including user manual and tutorial package, available in 1988; charge is approximately $750. For further information, contact Anne Yates, Oxford Electronic Publishing, Oxford University Press, Walton Street, Oxford OX2 6DP, England. Listing of reports published between 1940 and 1984 is available in: National Per~natal Epidemiology Unit: A Classified Bibliography of Controlled Trial in Peranatal Medicine, 1940-1984, Oxford University Press, 1985. PDQ (Physician Data Query) Source: International Cancer Information Center, Office of International Affairs, National Cancer Institute (NCI), Building 82 Room 103, Bethesda, MD 20892, 301- 496-7403 Subject: Advances in cancer treatment and clinical trials; designed for use by physi- aans. Content: Databank provides detailed summaries of all major tumor types, including prognosis, staging, cellular classification, and state-of-the-art treatment options. Con- tains comprehensive information on more than 1,000 active cancer-treatment proto 542

INFORMATION AND DATA RESOURCES colt approved by NCI. Protocol summaries include study objectives, patient entry criteria, and treatment regimen, as well as names, addresses, and telephone numbers of the principle investigators. Each protocol indexed according to disease, stage-specific eligibility criteria, and details of treatment. Physician directory contains information on more than 12,000 physicians who treat cancer patients. Organization directory has contact information for approximately 2,000 organizations associated with cancer treatment. See MEDLINE description for listing of NLM MEDLARS databases. Compilation: An editorial board of 70 cancer specialists solicits opinions from experts in oncology concerning treatment options to list; statements of treatment are formulat- ed and subsequently reviewed by consultants with expertise in cancer management. Editorial board maintains currency and accuracy of information on available cancer therapies, treatment research, physician, and organization directories through month- ly updates. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. To contact MEDLARS Manage- ment Division call 800-638-8480 or 301-496-6193 in Maryland. Connect cost averages $22/hour peak time, $15/hour off-peak. Also available through BRS 800-345-4277, COLLEAGUE (BRS/Saunders) 800-468-0908, and MEDIS (Mead Data Central) 800- 227-4908. Will be available in Europe on TELMED, a Swiss medical information system. Pha~maprojects Source: U.S. office: PharmaBooks, Ltd., 1775 Broadway, Suite 511, New York, NY, 10019. 212-262-8230. Head office: Pharmaprojects, 18/20 Hill Rise, Richmond, Sur- rey, TW10 6UA, United Kingdom, (44-1) 94-83-26-2 Subject: Pharmaceutical product development information. Content: Manufacturers Volume lists more than 4,000 products under development by more than 800 companies. Each product entry includes generic names, research codes, trade names, financial and other information about originating companies and licen- cees, standardized activity descriptors, stage of development, related text and literature references. Therapeutic Categories Volume lists product developments in particular thera- peutic fields arranged by an anatomically-based classification system. Monthly updates identifying recent developments parallel both annual volumes. Cumulative indexes available on products, manufacturers, product activity, and licensing opportunities. PHARMAPRO}ECTS ONLINE includes manufacturers and therapeutic categories information corresponding to printed version (PHAR file); additional online files contain information on products whose development has been discontinued (PHAD), and products that have been placed in major markets (PHAL). Compilation: Compiled from medical and scientific publications, brokers' reports, company annual reports, conference papers, and direct contacts with companies. Printed version updated monthly. Online version updated monthly (PHAR) and quar- terly (PHAD and PHAL). 543

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Access: Annual subscription for printed versions is $2,525 from U.S. office; subscrip- tions elsewhere available from Head office. PHARMAPROJECTS ONLINE available in U.S. on Data-Star via modem from remote terminal through TELENET, TYM- NET, AS-NET; available on other networks in other countries. Online access cost approximately $-110/hour plus $0.55/record for printed version subscribers and $30/ record for nonsubscribers; discounts available. Call 800-221-7754 for further informa- tion about access and use of Data-Star. POPLINE (Population information Online) Source: MEDLARS Management Section, National Library of Medicine (NLM), Build- ing 38, Room 4N421, 8600 Rockville Pike, Bethesda, MD 20894, 800-638-8480, 301- 496-6193 in Maryland. Subject: Population issues and family planning. Content: Database includes bibliographic citations and abstracts to documents relevant to human fertility, contraceptive methods, community-based services, program evalua- tion, demography, censuses, vital statistics, and related health, law and policy issues. See MEDLINE description for listing of NLM MEDLARS databases. Compilation: Compiled from journal articles, monographs, technical reports, and unpublished works. Coverage 1970 to present; selected citations date back to 1886. Updated monthly with approximately 10,000 citations added annually. POPLINE produced in cooperation with the Johns Hopkins University Population Information Program, Columbia University Center for Population and Family Health, Princeton University Population Index Library/Information Program, and the University of North Carolina at Chapel Hill Carolina Population Center; supported by U.S. Agency for International Development and National Institute of Child Health and Human Development. Access: Available online at any time through NLM MEDLARS computer system to more than 6,000 online centers in hospitals, medical schools, universities, government agencies, commercial firms, and other organizations throughout U.S., as well as MED- LARS centers located in 13 other countries. Also accessible via modem from remote terminal through TELENET, TYMNET, direct dial. Connect cost averages $22/hour peak time, $15/hour off-peak. Product Development Directory, Product SOS Source: Medical Device Register, Inc., 655 Washington Boulevard, Stamford, CT 06901, 800-222-3045, 203-348-6319 in Connecticut Subject: Non-drug medical products and product safety problems. Content: Product Development Directory indexes 40,000 510(k) filings on medical prod- ucts approved by the FDA since 1976, organized by product category. Product approv- als arranged historically within product category by FDA approval date; manufacturer and name of product approved are listed. Product SOS (Situation Occurrence Service) presents information on medical product problem reports. 1986 edition includes more than 3,000 user reports from DEN (Device Experience Network of FDA) for 1985 and 544

INFORMATION AND DATA RESOURCES 22,000 reports from MDR (Medical Device Reporting regulations of FDA) from begin- ning of MDR in December 1984 through first quarter of 1987. Included with 1986 edition are bimonthly alerts on new problems as they are reported. Compilation: information is gathered primarily from FDA sources, which delete certain confidential trade, commercial, financial, personnel, medical, and patient infor- mation. Product Development Directory was first issued in [anuary 1987. Product SOS updated regularly. Access: Product Development Directory price $87; Product SOS (1986 edition) price $360. Detailed documents, FDA 5 lO(k) filings on each product may be obtained from Medi- cal Device Register or FDA. Randomized Controlled Clinical Trials Report Collection Source: Thomas C. Chalmers, M.D., Harvard School of Public Health, 677 Hunting- ton Avenue, Kresge 4th Floor, Boston, MA 021 15, 617-732-1090 Subject: Randomized controlled clinical trials (RCTs) and meta-analyses of RCTs. Content: Database contains approximately 8,000 articles describing RCTs, quality assessments and meta-analyses in various fields, and methodological books and articles. Contents partially indexed. Compilation: Collection activities initiated in 1973. Information gathered through published and unpublished literature searches. Five to ten papers or abstracts based on the collection published yearly. Access: Collection partially supported by NLM. Database currently not machine- readable. Contact source for further information about access to collection. Report on Cost-Effective Products and Technologies Source: Friedman, Eisenstein, Raemer, and Schwartz (FER&S', Certified Public Ac- countants/Business and Personal Consultants, 401 North Michigan Avenue, Chicago, IL 6061 1, 312-644-6000 Subject: Cost-effectiveness of medical devices, pharmaceuticals, medical services, and other health care products. Designed for hospital administrators, medical directors, and other health care facility and industry managers. Content: Each report provides synopses of cost-effectiveness analyses of up to five medical products. Each synopsis describes the product, how it is used, and applicable diagnosis-related group (DRG) where appropriate. Study results and analysis are presented. Features of analysis discussed are product orientation (beneficiary of prod- uct's cost-effectiveness), study objectives, study methodology, production relationships (impact of product application on other labor, supply, equipment, and overhead resources), cost identification, differential benefit identification (product's cost-effec- tiveness versus alternative product-type or technique), and factors affecting study's scope and validity. Independent organization conducting or reviewing study and contact person at medical product company are identified. 545

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Compilation: Medical product and pharmaceutical companies submit cost-effective- ness analyses of their products to FERNS. Studies to be included in report are reviewed to determine whether they are methodologically valid, were conducted or reviewed by an independent third party, and involve an FDA-approved product. First report issued in October 1986; subsequent reports published quarterly. Access: Reports routinely distributed to selected hospital administrators nationwide. Copies of reports available upon request. S. crlp Source: U.S. Office: Scrip World Pharmaceutical News, 1775 Broadway, Suite 511, New York, NY, 10019, 212-262-8230. Head of rice: Scrip 18/20 Hill Rise, Richmond, Surrey, TWIG 6UA, United Kingdom, (44-1) 94-83-26-2 Subject: Pharmaceutical industry news, ~nc~uc~ng International industry, regulatory environment, development of new products, and company affairs. Content: 20-28 page newsletter on pharmaceutical products, finance, world news and markets, company news, advertising. Among other Scrip reports are Scrip Yearbook; Scrap's Pharmaceutical Company League Tables; New Product Reviews; monographs on such subjects as biotechnology companies, product liability, European drug registration, Japanese companies; and monographs on product types such as cardiovascular, che- motherapy, thrombolytics, and asthma. Scrip provides copies of selected FDA Summa- ry Bases of Approval reports, and recent FDA guidelines for new drug applications. The Scrip database PHIND (Pharmaceutical and Healthcare Industries News Data- base) is available online. It includes the text from Scrip and other publications in two files; PHID is updated daily, and PHIN contains Scrip archival material up to three weeks prior to the current date. Compilation: Scrip is published twice a week; 100 issues/year. PHIND is updated daily. Compiled from medical and scientific publications, brokers' reports, company annual reports, conference papers, and direct contacts with companies. Access: Annual Scrip subscription $523; $282 for additional copies sent in same envelope. PHIND is available in U.S. on Data-Star via modem from personal computer through TELENET, TYMNET, AS-NET; available on other networks in other coun- tries. PHIND online access costs approximately $ 110/hour, $ 1.55/current article, $0.35/ back article. Call 800-221-7754 for further information about access and use of Data- Star. SEER (SurveilIance, Epidemiology, and End Results Program) Source: Surveillance and Operations Research Branch, Blair Building, Room 532, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD 20892- 4200, 301-427-8829 Subject: Cancer surveillance and epidemiology. 546

INFORMATION AND DATA RESOURCES Content: Database provides statistical data on cancer incidence, mortality, and survival in about 10 percent of the U.S. population; based on several defined geographic areas: Connecticut, Iowa, Detroit, Atlanta and four rural counties in Georgia, Utah, Hawaii, New Mexico and Arizona Native Americans, San Francisco, Seattle, New Jersey, and Puerto Rico. Serves as basis for cancer research, cancer prevention and control research program evaluation. Data include cancer site, year of diagnosis, diagnostic procedures, histology, staging, treatment regimen and date initiated, follow up, i.e., date and cause of death or vital status, patient demographics. SEER issues Annual Cancer Statistics Review and reprints of monographs and numerous journal articles that detail research findings and examine other relevant topics. Compilation: Program activities initiated in 1973; 1 million records are on file. Infor- mation gathered from hospital/medical records and pathology reports of cancer cases. Access: Published SEER reports are available from source upon request; some are also available from U.S. Government Printing Office 202-783-3238. Requests for public use data tapes and for special data runs must be justified in writing. Online access to database is available to NIH users only. SPRILINE Source: Library and Research Report Bank, Swedish Planning and Rationalization Institute for the Health Services (SARI), Box 27310, S- 102 54, Stockholm, Sweden, (46- 8) 63-05-60 Subject: Health services administration and planning, health economics, health per- sonnel, health statistics, hospital construction, hospital equipment, hospital supplies, medical ethics, medical technology, nursing, social services. Content: Interactive online bibliographic database and library system includes refer- ences to literature, reports, organizations, and individuals; Swedish health services data; information on surveys and pilot projects. SPRILINE database includes 13,000 records of books, journal articles, and unpublished research reports on Swedish health care from Research Report Bank. About 15 percent of the records are from English language sources. All records for journal articles and research reports contain an abstract; searches can be made using free-text technique or controlled terms from thesaurus, which covers 1,200 Swedish indexing terms. Author, title, abstract, keywords, corporative author, publication year, serial title, and language fields may be searched. Printed products include indexes of books and journals, unpublished re- search reports, annual catalog of research report bank holdings, bibliography of pri- mary care. Subject-coded references of recently acquired books and journal articles are mailed 10 times/year to public health agencies and medical libraries in Sweden and abroad, including the American Hospital Association and the National Library of Medicine. Information about new acquisitions is published in news bulletin Spry Infor merar. Compilation: More than 3,000 records are added each year, including 1,300 books, 1,000 journal articles, and 700 research reports. System is linked to other libraries in Sweden, and participates in the HECLINET (Health Care Literature Information Network) European documentation service. SPRILINE has been available for online searching since 1984. 547

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Access: User ID and password are available from source. SPRILINE is available online via modem from remote terminals all hours except 2am-4am Wednesdays and Fridays. Telephone inquiries accepted 9am-3pm weekdays. Document delivery service supplies copies of journal articles and lends books and reports; document requests can be made online via electronic mailbox, mail, and telephone. Except for a nominal fee for multiple photocopies, SPRILINE has no access charges. Technical Data Center Source: Occupational Safety and Health Administration (OSHA), U.S. Department of Labor, 200 Constitution Avenue, NW, Room N2439, Washington, DC 20210,202-523- 9700 Subject: Occupational safety and health, including biochemistry, analytical chemistry, biology, physiology, industrial toxicology, sampling and analysis, ergonomics, engi- neering, health physics, radiology, industrial medicine and health, environmental health, industrial hygiene, sanitation, and safety. Content: TDC collection contains books and monographs (approximately 5,000), ency- clopedias, subject and language dictionaries, various specialized guides, and approxi- mately 250 technical journals; complete list of journals and years covered is available. Available on microfiche: dissertations, abstracts, standards material, product catalogs, back issues of the Federal Register, technical papers, reports, publications, material safety data sheets, and numerous publications from government agencies, e.g., National Bureau of Standards, National Institute for Occupational Safety and Health. TDC docket office maintains collection of OSHA rulemaking files, as well as transcripts of advisory committee meetings and impact statements. In-house computerized database, Technical Information Retrieval System includes docket office files, TDC collection, and card catalog. TDC distributes monthly compendium of table of contents of recent journals and publishes quarterly TDC Information and Insight Bulletin. Subject bibliogra- phies prepared through manual and online searches available upon written request. Compilation: TDC established in 1972. Collection compiled of published and unpub- lished documents acquired from various federal agencies, private industry, research organizations, and private standards setting organizations. Technical Information Re- trieval System created in 1983; updated continuously. Subject bibliographies updated quarterly. Access: Information regarding the use of Technical Data Center (TDC) reference materials and services is available upon request. In-house database may be used free of charge. TDC resources committed primarily to meeting needs of OSHA program activities in national office and field offices; however, non-government personnel may use center during office hours for reference purposes. U.S. Industrial Outlook Source: Industry Publications Division, Office of Industrial Assessment, International Trade Administration, Trade Development, U.S. Department of Commerce, 14th Street and Constitution Avenue, NW, Washington, DC 20230, 202-377-4356 548

INFORMATION AND DATA RESOURCES Subject: Economic data and analyses of specific U.S. industries, including drugs, medical and dental instruments and supplies, and health and medical services. Content: Each of nearly 70 chapters in this annual volume covers one or more Stan- dard Industrial Classifications (SICs) of industry types. Chapters generally address each SIC's current situation, outlook for that year, and long-term prospects. Historical trends are given for each industry and type of product, and for international trade. Chapters relevant to medical technology include drugs (covering SICs for biologicals, medicinals and botanicals, and pharmaceutical preparations), medical and dental in- struments and supplies (x-ray and electromedical equipment, surgical and medical instruments, surgical appliances and supplies, and dental equipment and supplies), and health and medical services. Chapters address such topics as industry production levels, domestic and foreign-based R&D expenditures, levels of innovation, international competition, areas of new product development, and impact of government regula- tions and policies. Compilation: Published annually. The edition for any given year is written during the third quarter of the previous year, based on data that are generally two years old. Data for the intervening years are estimated, and data for the current year are forecasts. Data are compiled from Bureau of the Census sources, as well as other government and private sector sources appropriate for each industry. Access: Can be purchased for $24 from U.S. Government Printing Office 202-783- 3238, (order 003-008-00200-51; U.S. Department of Commerce federal bookstore; or local Commerce district offices. Inquiries about the content of the volume may be directed to the industry specialist whose name and telephone number appears at the end of each chapter or section. WHO/:~INFO Database on Health Technology Assessment Source: joint effort of Department of Computer and Information Science and Center for Medical Technology Assessment, Linkoping University, S-581 83 Linkoping, Swe- den, (46-13) 28-19-69; and Regional Office for Europe, Hospital Programme, World Health Organization, 8 Scherf~gsvej, DK-2100 Copenhagen, Denmark, (45- 1) 29-06- 1-9 . Subject: Organizational based information about health technology assessment activi- ties and reports. Content: Information collected from more than 140 primarily European organiza- tions. Records for descriptions of each assessment program include program name, contact person, address, telephone number, electronic mail address, type of institution (university, research institute, professional association, etc.), staff size, how assessments are initiated, types of technologies assessed (e.g., drugs, devices, procedures, etc.), list of assessments carried out, means of report dissemination, other services, organizational databases and means of accessing them, and availability of annual report. First product of information base is WHOILINFO Directory, in which program descriptions are ar- ranged by country and by type of technology usually assessed. Assessment reports records to include author, title, keywords or other indexing terms, abstract, and other bibliographic information. 549

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Compilation: Database compiled by surveys of health related programs in Europe, Australia, Canada, and U.S. Planning and organizational based information collection initiated in late 1986; collection of bibliographic information for assessment reports initiated in 1987. Planning underway to initiate WHO/LINNET, a user network based on WHO/LINFO database. Access: WHO/LINFO directory available from Linkping sources. World Health Organization Publications Source: World Health Organization (WHO), 1211 Geneva 27, Switzerland, (41-21) 91- 21-1 1 Subject: Public health, including epidemiological data and statistical indicators. Content: Books, reports, monographs, periodicals covering such topics as biologicals, pharmaceuticals, radiation and health, laboratories, health systems development, hos- pitals and health care facilities, human rights and medical ethics, immunology and immunization, health economics and expenditures, health statistics, cancer, cardiovas- cular diseases, chronic diseases, environmental health, health of the elderly. Public Health Papers focuses on modern trends and changing concepts in public health, Technical Report Series covers consensus findings and recommendations on medical and public health issues, quarterly journal World Health Forum presents new concepts in public health and new approaches to health problems, bimonthly Bulletin of the World Health Organization reviews progress in medical and related scientific research, World Health Statistics Quarterly assesses health situation worldwide and projects future trends, Weekly Epidemiolog~cal Record contains notifications of diseases and epidemiological data on diseases of international importance. Others include numerous regional publica- tions, publications of the International Agency for Research on Cancer, and publica- tions of the Council for International Organizations of Medical Sciences. Catalog contains author and subject index. Compilation: WEIO activities initiated in 1948. Information gathered from WHO programs, activities, and consensus reports of international groups of experts. WHO reports published continuously; new books featured in catalog issued every six months. Access: Catalog of publications available upon request. 55O

INFORMATION AND DATA RESOURCES SUBJECT INDEX TO INFORMATION AND DATA RESOURCES Academic health services Directory of Health Services Research Organi- zations Alcohol Alcohol, Drug Abuse, and Mental Health Ad- ministration Publications and Data Ambulatory medical care National Center for Health Statistics Publica- tions and Data Behavioral risk factors Center for Health Promotion and Education Biomedical engineering BMEDSS Market Research Reports Multi-Client Reports Bioethics BIOETHICSLINE SPRILINE Birth defects Birth Defects and Developmental Disabilities Reports Blood diseases NHLBI Publications Blood resources NHLBI Publications Cancer CANCERLIT CLINPROT Duke Comprehensive Cancer Center Database PDQ SEER Cardiovascular diseases NHLBI Publications Chronic diseases Environmental Health Laboratory Sciences Re- ports Cholesterol National Cholesterol Education Program/ NHLBI Smoking Education Program Infor- mation Center Clinical trials CLINPROT Oxford Database of Perinatal Trials PDQ Randomized Controlled Clinical Trials Report Collection Cost effectiveness Report on Cost-Effective Products and Tech- nologies CPT-4 codes AMA/NET Current awareness services AMA/NET BRS FDA Bulletin Board F-D-C Reports Futures Program Health Devices Alerts MEDLINE NEXIS Scrip 551

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Database utilities BRS COLLEAGUE DIALOG MEDLINK Developmental disabilities Birth Defects and Developmental Disabilities Reports Diagnosis INTERNIST 1/Quick Medical Reference Disasters Environmental Hazards and Health Effects Re ports DRGs Baseline Reports Drug abuse Alcohol, Drug Abuse, and Mental Health Ad ministration Publications and Data Drug utilization review SEE Pharmaceuticals Environmental health Environmental Hazards and Health Effects Re ports Health planning Environmental Health Laboratory Sciences Re- HEALTH ports Technical Data Center Evaluation studies Compendium of HHS Evaluations and Rele vant Other Studies Expert systems INTERNIST 1/Quick Medical Reference Family planning National Center for Health Statistics Publica tions and Data POPLINE Genetic diseases Birth Defects and Developmental Disabilities Report 552 Health administration HEALTH SPRILINE Health care delivery AMA/NET HEALTH National Reference File Health care data SEE ALSO Hospital data, Patient data Abstracts of Health Care Machine-Readable Data Files NAHDO Resource Manual National Reference File Health care economics Baseline Reports National Center for Health Statistics Publica- tions and Data Health care product manufacturers Health Devices Sourcebook Medical Device Register National Reference File Pharmaprojects Help U.S. Industrial Outlook Health policy BIOETHICSLINE Current Assessments, New Technology Ab- stracts Directory of University-Based Health Services and Policy Research Centers Health promotion Center for Health Promotion and Education HEALTH High Blood Pressure Information Center National Cholesterol Education Program/ NHLBI Smoking Education Program Information Center Health services research Current Assessments, New Technology Ab- stracts Directory of Health Services Research Organizations

INFORMATION AND DATA RESOURCES Health statistics National Center for Health Statistics Publica- tions and Data World Health Organization Publications High blood pressure High Blood Pressure Information Center Hospital data SEE ALSO Health care data, Patient data Baseline Reports CHPA Files NAHDO Resource Manual National Center for Health Statistics Publica- tions and Data Hospital supplies IMS Audits SP1lILINE Hospitals HEALTH HECLINET National Center for Health Statistics Publica- tions and Data SPRILINE Internal medicine INTERNIST 1/Quick Medical Reference International health World Health Organization Publications Laboratory products BMEDSS Device Experience Network IMS Audits Market Research Reports Medical Device and Laboratory Product Prob- lem Reporting Program Medical Device Reporting Report on Cost-Effective Products and Tech- nologies Legal issues BIOETHICSLINE HEALTHLAWYER Market research Futures Program IMS Audits International Market Research Studies Market Research Reports Market/Technology Reports Multi-Client Reports fed - ~crlp U.S. Industrial Outlook Medical appropriateness HIAA Medical Appropriateness Compilation National Reference File Medical devices BMEDSS Device Experience Network FDA Bulletin Board Health Devices Alerts Health Devices Sourcebook Market Research Reports Medical Device and Laboratory Product Prob- lem Reporting Program Medical Device Register Product Development Directory/Product SOS Report on Cost-Effective Products and Tech- nologies Medical practice variations CCC Bibliography on Regional Variations in Health Care IMS Audits National Reference File Medical technology assessments Current Assessments, New Technolgy Abstracts WHO/LINFO Database on Health Technology Assessment Medicine (General) AMA/NET BRS COLLEAGUE DIALOG MEDIS MEDLINE Mental health Alcohol, Drug Abuse, and Mental Health Ad- ministration Publications and Data 553

MEDICAL TECHNOLOGY ASSESSMENT DIRECTORY Nutrition Center for Health Promotion and Education National Center for Health Statistics Publica tions and Data Occupational safety and health Technical Data Center Organizational directories Directory of Health Services Research Organizations DIRLINE Health Devices Sourcebook Pulmonary diseases Health Information Resources in the Federal NHLBI Publications Government Patents CASSIS Patient data SEE ALSO Health care data, Hospital data Baseline Reports CPHA Files Patient discharge SEE Hospital data Perinatal medicine Oxford Database of Perinatal Trials Pharmaceuticals BMEDSS Boston Collaborative Drug Surveillance Pro gram COMPASS Drug Problem Reporting Program FDA Bulletin Board F-D-C Reports IMS Audits Market Research Reports Pharmaprojects Report on Cost-Effective Products and Tech nologies ~ . scalp Population POPLINE Postmarketing surveillance BMEDSS Boston Collaborative Drug Surveillance Pro gram 554 COMPASS Device Experience Network Drug Product Reporting Program Health Devices Alerts Medical Device and Laboratory Product Prob- lem Reporting Program Medical Device Reporting Product Development Directory/Product SOS Public health World Health Organization Publications Registries Birth Defects and Developmental Disabilities Reports Duke Comprehensive Cancer Center Database Reproductive health Center for Health Promotion and Education Research programs CRISP Current Assessments, New Technology Ab- stracts IMPAC National Technical Information Service Publi- cations and Data Smoking National Cholesterol Education Program/ NHLBI Smoking Education Program In- formation Center Toxic agents Environmental Hazards and Health Effects Re- ports Environmental Health Laboratory Sciences Re- ports Technical Data Center Vital statistics National Center for Health Statistics Publica- tions and Data

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Medical Technology Assessment Directory: A Pilot Reference to Organizations, Assessments, and Information Resources Get This Book
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For the first time, a single reference identifies medical technology assessment programs. A valuable guide to the field, this directory contains more than 60 profiles of programs that conduct and report on medical technology assessments. Each profile includes a listing of report citations for that program, and all the reports are indexed under major subject headings. Also included is a cross-listing of technology assessment report citations arranged by type of technology headings, brief descriptions of approximately 70 information sources of potential interest to technology assessors, and addresses and descriptions of 70 organizations with memberships, activities, publications, and other functions relevant to the medical technology assessment community.

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