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Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels

Subcommittee on Acute Exposure Guideline Levels

Committee on Toxicology

Board on Environmental Studies and Toxicology

Division on Earth and Life Studies

NATIONAL RESEARCH COUNCIL OF THE NATIONAL ACADEMIES

THE NATIONAL ACADEMIES PRESS
Washington, D.C.
www.nap.edu

Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
×

THE NATIONAL ACADEMIES PRESS
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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This project was supported by Contract Nos. DAMD 17-89-C-9086 and DAMD 17-99-C-9049 between the National Academy of Sciences and the U.S. Army. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

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Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
×

THE NATIONAL ACADEMIES

Advisers to the Nation on Science, Engineering, and Medicine

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Bruce M. Alberts is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Wm. A. Wulf is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine.

The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Bruce M. Alberts and Dr. Wm. A. Wulf are chair and vice chair, respectively, of the National Research Council.

www.national-academies.org

Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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SUBCOMMITTEE ON ACUTE EXPOSURE GUIDELINE LEVELS

DANIEL KREWSKI (Chair),

University of Ottawa, Ottawa, Ontario

EDWARD C. BISHOP,

Parsons Corporation, Pasadena, CA

JAMES V. BRUCKNER,

University of Georgia, Athens

RAKESH DIXIT,

Merck and Company, Inc., West Point, PA

JEFFREY W. FISHER,

University of Georgia, Athens

DONALD E. GARDNER,

Inhalation Toxicology Associates, Raleigh, NC

DAVID P. KELLY,

Dupont Company, Newark, DE

STEPHEN U. LESTER,

Center for Health, Environment, and Justice, Falls Church, VA

JUDITH MACGREGOR,

Toxicology Consulting Services, Arnold, MD

PATRICIA M. MCGINNIS,

Syracuse Research Corporation, Ft. Washington, PA

FRANZ OESCH,

University of Mainz, Mainz, Germany

RICHARD B. SCHLESINGER,

Pace University, New York, NY

CALVIN C. WILLHITE,

State of California, Berkeley

FREDERIK A. DE WOLFF,

Leiden University Medical Center, Leiden, Netherlands

Staff

KULBIR S. BAKSHI, Project Director

ALEXANDRA STUPPLE, Senior Editorial Assistant

AIDA C. NEEL, Program Associate

Sponsor

U.S. DEPARTMENT OF DEFENSE

Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
×

COMMITTEE ON TOXICOLOGY

WILLIAM E. HALPERIN (Chair),

New Jersey Medical School, Newark

LAWRENCE S. BETTS,

Eastern Virginia Medical School, Norfolk

EDWARD C. BISHOP,

Parsons Corporation, Pasadena, CA

JAMES V. BRUCKNER,

University of Georgia, Athens

GARY P. CARLSON,

Purdue University, West Lafayette, IN

JANICE E. CHAMBERS,

Mississippi State University, Mississippi State

MARION EHRICH,

College of Veterinary Medicine, Blacksburg, VA

SIDNEY GREEN,

Howard University, Washington, DC

MERYL KAROL,

University of Pittsburgh, Pittsburgh, PA

JAMES MCDOUGAL,

Wright State University School of Medicine, Dayton, OH

ROGER MCINTOSH,

Science Applications International Corporation, Abingdon, MD

GERALD N. WOGAN,

Massachusetts Institute of Technology, Cambridge

Staff

KULBIR S. BAKSHI, Program Director

ROBERTA M. WEDGE, Senior Program Officer for Risk Analysis

SUSAN N. J. MARTEL, Senior Program Officer

ELLEN K. MANTUS, Senior Program Officer

ALEXANDRA STUPPLE, Senior Editorial Assistant

AIDA NEEL, Program Associate

TAMARA DAWSON, Program Assistant

SAM BARDLEY, Library Assistant

Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
×

BOARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY1

Members

JONATHAN M. SAMET (Chair),

Johns Hopkins University, Baltimore, MD

RAMON ALVAREZ,

Environmental Defense, Austin, TX

THOMAS BURKE,

Johns Hopkins University, Baltimore, MD

JUDITH C. CHOW,

Desert Research Institute, Reno, NV

RORY B. CONOLLY,

CIIT Centers for Health Research, Research Triangle Park, NC

COSTEL D. DENSON,

University of Delaware, Newark

E. DONALD ELLIOTT,

Wilkie, Farr & Galagher, LLP, Washington, DC

CHRISTOPHER B. FIELD,

Carnegie Institute of Washington, Stanford, CA

WILLIAM H. GLAZE,

Oregon Health and Sciences University, Beaverton

SHERRI W. GOODMAN,

Center for Naval Analyses Corporation, Alexandria, VA

JUDITH A. GRAHAM,

American Chemistry Council, Arlington, VA

DANIEL S. GREENBAUM,

Health Effects Institute, Cambridge, MA

ROBERT HUGGETT,

Michigan State University, East Lansing

BARRY L. JOHNSON,

Emory University, Atlanta, GA

JAMES H. JOHNSON,

Howard University, Washington, DC

JUDITH L. MEYER,

University of Georgia, Athens

PATRICK Y. O’BRIEN,

ChevronTexaco Energy Technology Company, Richmond, CA

DOROTHY E. PATTON,

International Life Sciences Institute, Washington, DC

STEWARD T.A. PICKETT,

Institute of Ecosystem Studies, Millbrook, NY

JOSEPH V. RODRICKS,

Environ Corp., Arlington, VA

ARMISTEAD G. RUSSELL,

Georgia Institute of Technology, Atlanta

MITCHELL J. SMALL,

Carnegie Mellon University, Pittsburgh, PA

LISA SPEER,

Natural Resources Defense Council, New York, NY

KIMBERLY M. THOMPSON,

Harvard School of Public Health, Boston, MA

G. DAVID TILMAN,

University of Minnesota, St. Paul

CHRIS G. WHIPPLE,

Environ Incorporated, Emeryville, CA

LAUREN A. ZEISE,

California Environmental Protection Agency, Oakland

Senior Staff

JAMES J. REISA, Director

DAVID J. POLICANSKY, Scholar

RAYMOND A. WASSEL, Senior Program Officer for Environmental Sciences and Engineering

KULBIR BAKSHI, Senior Program Officer for Toxicology

ROBERTA M. WEDGE, Senior Program Officer for Risk Analysis

K. JOHN HOLMES, Senior Program Officer

SUSAN N.J. MARTEL, Senior Program Officer

SUZANNE VAN DRUNICK, Senior Program Officer

EILEEN N. ABT, Senior Program Officer

ELLEN K. MANTUS, Senior Program Officer

RUTH E. CROSSGROVE, Senior Editor

1  

This study was planned, overseen, and supported by the Board on Environmental Studies and Toxicology.

Page viii Cite
Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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PREFACE

Extremely hazardous substances (EHSs)1 can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars or trucks transporting EHSs, or intentionally through terrorist activities. However, it is also feasible that these substances can also be released by improper storage and/or handling. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation’s railways and highways are potentially at risk of being exposed to airborne EHSs during accidental and intentional releases. Pursuant to the Superfund Amendments and Reauthorization Act of 1986, the U.S. Environmental Protection Agency (EPA) has identified approximately 400 EHSs on the basis of acute lethality data in rodents.

The National Advisory Committee (NAC) on Acute Exposure Guideline Levels for Hazardous Substances has developed acute exposure guideline levels (AEGLs) for approximately 120 EHSs to date. In 1998, EPA and the U.S. Department of Defense (DOD) requested that the National Research Council (NRC) independently review the AEGLs developed by the NAC. In response to that request, the NRC organized within its Committee on Toxicology the Subcommittee on Acute Exposure Guideline Levels. The NAC’s Standing Operating Procedures for Developing AEGLs for Airborne Chemicals was reviewed by the subcommittee and published in May 2001. That report provides step-by-step guidance for the derivation of AEGLs for hazardous chemicals. In December 2000, the subcommittee’s first report, Acute Exposure Guideline Levels for Selected Airborne Chemicals, Volume 1, was published by the NRC; volumes 2, 3, and 4 in that series were published in 2002, 2003, and 2004 respectively.

The subcommittee meets two times each calendar year. At those meetings, the subcommittee hears presentations from the NAC staff and its contractor—the Oak Ridge National Laboratory—on draft AEGL documents. At some meetings, the subcommittee also hears presentations from NAC’s collaborators from other countries, such as Germany. The subcommittee provides comments and recommendations on those documents to NAC in its interim reports, and the NAC uses those comments to make revisions. The revised reports are presented by the NAC to the subcommittee at subsequent meetings until the subcommittee concurs with the final draft documents. The revised reports are then published as appendices in the subcommittee’s reports.

The present report is the subcommittee’s twelfth interim report. It summarizes the subcommittee’s conclusions and recommendations for improving NAC’s AEGL documents for 15 chemicals: Toluene, xylenes, ammonia, bromine, aniline, methyl ethyl ketone, hydrazine, iron pentacarbonyl, phosphine, chlorine trifluoride, ethyleneimine, propyleneimine, allyl alcohol, ethylene oxide, and nickel carbonyl.

This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the NRC’s

1  

As defined pursuant to the Superfund Amendments and Reauthorization Act of 1986.

Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We wish to thank the following individuals for their review of this report: Deepak K. Bhalla (Wayne State University), Sam Kacew (University of Ottawa), and Bernard M. Wagner (New York University Medical Center).

Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations, nor did they see the final draft of the report before its release. The review of this report was overseen by: David W. Gaylor of Gaylor and Associates, LLC. Appointed by the NRC, he was responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.

The subcommittee gratefully acknowledges the valuable assistance provided by the following people: Ernest Falke and Paul Tobin (both from EPA); Cheryl Bast, Kowetha Davidson, Sylvia Milanez, Sylvia Talmage, Claudia Troxel, and Robert Young (all from Oak Ridge National Laboratory). Aida Neel was the program associate and Alexandra Stupple was the editor. We are grateful to James J. Reisa, director of the Board on Environmental Studies and Toxicology, for his helpful guidance. The subcommittee particularly acknowledges Kulbir Bakshi, project director for the subcommittee, for bringing the report to completion. Finally, we would like to thank all members of the subcommittee for their expertise and dedicated effort throughout the development of this report.

Daniel Krewski, Chair

Subcommittee on Acute Exposure Guideline Levels

William E. Halperin, Chair

Committee on Toxicology

Suggested Citation:"Front Matter." National Research Council. 2005. Twelfth Interim Report of the Subcommittee on Acute Exposure Guideline Levels. Washington, DC: The National Academies Press. doi: 10.17226/11224.
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Extremely hazardous substances (EHSs), as defined in the Superfund Amendments and Reauthorization Act of 1986, can be released accidentally as a result of chemical spills, industrial explosions, fires, or accidents involving railroad cars or trucks used in transporting these substances, or intentionally through terrorist activities. It is also feasible that these substance can be released by improper storage and/or handling. Workers and residents in communities surrounding industrial facilities where EHSs are manufactured, used, or stored and in communities along the nation’s railways and highways are potentially at risk of being exposed to airborne EHSs during accidental and intentional releases.

This report provides technical guidance on establishing community Acute Exposure Guideline Levels (AEGLs) for certain hazardous chemicals. It reviews the scientific validity of AEGLs developed by the national Advisory Committee on Acute Exposure Guideline Levels for Hazardous Substances, identifies research priorities, and identifies guidance issues that may require modification or further development based on the toxicological database for the chemicals reviewed. This twelfth interim report offers recommendations for improving AEGLs for the following 15 chemicals: toluene, xylenes, ammonia, bromine, aniline, methyl ethyl ketone, hydrazine, iron pentacarbonyl, phosphine, chlorine, trifluoride, ethyleneimine, propyleneimine, allyl alcohol, ethylene oxide, and nickel carbonyl.

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