Appendix A
Statement of Task
AN AD HOC COMMITTEE will produce a consensus report on the development of polio antivirals as a potential element of the Global Polio Eradication Initiative. The report will address the following issues:
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The feasibility and appropriateness of using a polio antiviral drug in the post-eradication era
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The properties a polio antiviral compound would need in order to meet the goals of the eradication program
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The most promising targets for polio antiviral drug development
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A comparison of different approaches to polio antiviral drug development, including an assessment of the required scientific expertise, infrastructural needs, risks, obstacles, and relative costs
As appropriate, the committee will make recommendations on whether and how to proceed with the development of a polio antiviral.