National Academies Press: OpenBook

Advancing Nuclear Medicine Through Innovation (2007)

Chapter: Appendix C Commercially Available Radiopharmaceuticals

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Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
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Appendix C
Commercially Available Radiopharmaceuticals

Radiopharmaceutical

Trade Name

Primary Uses

Carbon-14 Urea

Pytest

Detection of H Pylori

Cobalt-57 cyanocobalamin

Rubratope

Schilling test

Chromium-51 sodium chromate

Chromitope (Bracco)

Mallinckrodt Cr-51

Labeling red blood cells (RBC)

Fluorine-18-FDG

 

Positron emission tomography (PET) imaging

Gallium-67

Neoscan (GE)

DuPont Ga-67

Mallinckrodt Ga-67

Soft-tissue tumor and inflammatory process imaging

Indium-111 chloride

Indiclor (Nycomed)

Mallinckrodt In-111Cl

Labeling monoclonal antibodies and peptides (OncoScint & Octreoscan)

Indium-111 pentetate (DTPA)

Indium DTPA In-111

Imaging of cerebrospinal fluid kinetics

Indium-111 oxyquinoline (oxine)

Indium-111 oxine

Labeling leukocytes and platelets

Indium-111 Capromab pendetide

ProstaScint

Monoclonal antibody for imaging prostate cancer

Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×

Radiopharmaceutical

Trade Name

Primary Uses

Indium-111 pentetreotide

Octreoscan

Imaging neuroendocrine tumors

I-123 sodium iodide

Mallinckrodt

Amersham

Thyroid imaging and uptake

I-125 iothalamate

Glofil

Measurement of glomerular filtration

I-125 human serum albumin (RISA)

Isojex

Plasma volume determinations

I-131sodium iodide

Iodotope (Bracco)

CIS - I-131

Mallinckrodt I-131Soln

Mallinckrodt I-131 Therapy Caps

Mallinckrodt I-131 Diagnostic Caps

Thyroid uptake, imaging, and therapy

Tositumomab & Iodine I-131 Tositumomab

Bexxar

Treatment of non-Hodgkin’s lymphoma

I-131 iodomethylnorcholesterol (NP-59)

(University of Michigan)

Adrenal imaging

I-131 metaiodobenzylguanidine (MIBG)

I-131 MIBG

Imaging pheochromocytomas and neuroblastomas

P-32 chromic phosphate

Phosphocol P32

Therapy for intracavitary malignancies

P-32 sodium phosphate

 

Therapy for polycythemia vera

Rubidium-82 (from Sr-82/Rb-82 generator)

Cardio-Gen-82

PET imaging

Samarium-153 Lexidronam (Sm-153 EDTMP)

Quadramet

Palliative treatment of bone pain of skeletal metastases

Strontium-89

Metastron

Palliative treatment of bone pain of skeletal metastases

Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×

Radiopharmaceutical

Trade Name

Primary Uses

Tc-99m pertechnetate Generators

DuPont

Mallinckrodt DTE

Mallinckrodt FM

Amersham

Imaging thyroid, salivary glands, ectopic gastric mucosa, parathyroid glands, dacryocystography, cystography

Tc-99m Apcitide

AcuTect

Peptide imaging of deep vein thrombosis

Tc-99m bicisate (ECD)

Neurolite

Cerebral perfusion imaging

Tc-99m disofenin (DISIDA)

Hepatolite-CIS

Hepatobiliary imaging

Tc-99m exametazine (HMPAO)

Ceretec

Cerebral perfusion imaging

Tc-99m Gluceptate

Draximage

Mallinckrodt

Renal imaging

Tc-99m human serum albumin (HSA)

 

Imaging cardiac chambers

Tc-99m macroaggregated albumin (MAA)

Pulmolite - CIS

Macrotec (Bracco)

Technescan MAA (Mallinckrodt)

Draximage

Amersham MAA

Pulmonary perfusion

Tc-99m Mebrofenin

Choletec

Hepatobiliary imaging

Tc-99m Medronate (MDP)

Bracco

Osteolite - CIS

Draximage

Mallinckrodt

Amersham

Bone imaging

Tc-99m Mertiatide

Technescan MAG3

Renal imaging

Tc-99m Oxidronate (HDP)

Mallinckrodt HDP

Bone imaging

Tc-99m Pentetate (DTPA)

Techneplex (Bracco)

CIS-AN DTPA

CIS-DTPA

Draximage DTPA

Mallinckrodt DTPA

Nycomed DTPA

Renal imaging and function studies; Radioaerosol ventilation imaging

Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×

Radiopharmaceutical

Trade Name

Primary Uses

Tc-99m Pyrophosphate (PYP)

Phosphotec (Bracco)

Pyrolite-CIS

Pyro-CIS

Technescan PYP

Amersham PYP

Avid infarct imaging; in vivo RBC labeling

Tc-99m red blood cells

Ultratag

Imaging gastrointestinal (GI) bleeds, cardiac chambers

Tc-99m Sestamibi

Cardiolite

Miraluma

Myocardial perfusion imaging

Breast tumor imaging

Tc-99m Succimer (DMSA)

Amersham DMSA

Renal imaging

Tc-99m Sulfur Colloid (SC)

CIS-Sulfur Colloid

Nycomed - SC

Imaging liver/spleen, gastric emptying, GI bleeds

Tc-99m Tetrofosmin

Myoview

Myocardial perfusion imaging

Thallium-201

DuPont

Mallinckrodt

Amersham

Myocardial perfusion imaging; Parathyroid and tumor imaging

Y-90 Ibitumomab Tiuxetan

Zevalin

non-Hodgkin’s lymphoma

Xenon-133

DuPont Xenon

Mallinckrodt Xenon

Amersham Xenon

Pulmonary ventilation imaging

Interventional Agents

Trade Name

Use in nuclear medicine

ACD solution (anticoagulant acid Acitrate dextrose)

ACD Solution Modified

Anticoagulant used in blood labeling

Adenosine

Adenoscan

Pharmacologic stress

Ascorbic acid

Ascorbic acid

RBC labeling and HDP preparation

I.V. Dipyridamole

I.V. Persantine

Pharmacologic stress

Sincalide

Kinevac

Gallbladder ejection fraction studies

SOURCE: University of Arkansas for Medical Sciences (http://nuclearpharmacy.uams.edu/resources/PackageInserts.asp).

Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×
Page 151
Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×
Page 152
Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×
Page 153
Suggested Citation:"Appendix C Commercially Available Radiopharmaceuticals." Institute of Medicine and National Research Council. 2007. Advancing Nuclear Medicine Through Innovation. Washington, DC: The National Academies Press. doi: 10.17226/11985.
×
Page 154
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Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized.

Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.

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