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Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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INTERNATIONAL
ANIMAL RESEARCH
REGULATIONS

Impact on Neuroscience Research

WORKSHOP SUMMARY

Diana E. Pankevich, Theresa M. Wizemann, Anne-Marie Mazza, and
Bruce M. Altevogt, Rapporteurs

Forum on Neuroscience and Nervous System Disorders

Board on Health Sciences Policy

Committee on Science, Technology, and Law

Policy and Global Affairs Division

Institute for Laboratory Animal Research

Division on Earth and Life Sciences

     INSTITUTE OF MEDICINE AND
NATIONAL RESEARCH COUNCIL

                      OF THE NATIONAL ACADEMIES

THE NATIONAL ACADEMIES PRESS

Washington, D.C.

www.nap.edu

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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THE NATIONAL ACADEMIES PRESS     500 Fifth Street, NW     Washington, DC 20001

NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

This project was supported by contracts between the National Academy of Sciences and the Alzheimer’s Association; AstraZeneca Pharmaceuticals, Inc.; CeNeRx Biopharma; the Department of Health and Human Services’ National Institutes of Health (NIH, Contract Nos. N01-OD-4-2139) through the National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, National Eye Institute, NIH Blueprint for Neuroscience Research, National Institute of Mental Health, and National Institute of Neurological Disorders and Stroke; Eli Lilly and Company; Foundation for the National Institutes of Health; GE Healthcare, Inc.; GlaxoSmithKline, Inc.; Johnson & Johnson Pharmaceutical Research and Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson’s Research; the National Multiple Sclerosis Society; the National Science Foundation (Contract No. OIA-0753701); Pfizer Inc.; and the Society for Neuroscience. The views presented in this publication are those of the editors and attributing authors and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

International Standard Book Number-13: 978-0-309-25208-9

International Standard Book Number-10: 0-309-25208-3

Additional copies of this report are available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

For more information about the Institute of Medicine, visit the IOM home page at: www.iom.edu.

Copyright 2012 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America

The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of Medicine is a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.

Suggested citation: IOM (Institute of Medicine) and NRC (National Research Council). 2012. International animal research regulations: Impact on neuroscience research: Workshop summary. Washington, DC: The National Academies Press.

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

 

THE NATIONAL ACADEMIES

Advisers to the Nation on Science, Engineering, and Medicine

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Charles M. Vest is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine.

The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles M. Vest are chair and vice chair, respectively, of the National Research Council.

www.national-academies.org

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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U.S. AND EUROPEAN ANIMAL RESEARCH REGULATIONS: IMPACT ON NEUROSCIENCE RESEARCH PLANNING COMMITTEE*

COLIN BLAKEMORE (Co-Chair), Oxford University

ARTHUR SUSSMAN (Co-Chair), MacArthur Foundation

ROBERTO CAMINITI, University of Rome

JUDY MacARTHUR CLARK, Animals Scientific Procedures Inspectorate

RICHARD CUPP, Pepperdine Law School

MARGARET LANDI, GlaxoSmithKline

ALAN LESHNER, American Association for the Advancement of Science

RICHARD NAKAMURA, National Institute of Mental Health

TIMO NEVALAINEN, University of Eastern Finland

MICHAEL OBERDORFER, National Eye Institute (Retired)

FRANKIE TRULL, Foundation for Biomedical Research

Study Staff

BRUCE M. ALTEVOGT, Project Director, Institute of Medicine

DIANA E. PANKEVICH, Associate Program Officer, Institute of Medicine

LEILA AFSHAR, Research Associate, Institute of Medicine (until August 2011)

LORA K. TAYLOR, Senior Project Assistant, Institute of Medicine (until December 2011)

ANNE-MARIE MAZZA, Director, Committee on Science Technology and Law, National Research Council

LIDA ANESTIDOU, Senior Program Officer, Institute for Laboratory Animal Research, National Research Council



image

* Institute of Medicine forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

FORUM ON NEUROSCIENCE AND NERVOUS SYSTEM DISORDERS*

ALAN LESHNER (Chair), American Association for the Advancement of Science

HUDA AKIL, University of Michigan

MARC BARLOW, GE Healthcare, Inc.

MARK BEAR, Massachusetts Institute of Technology

DANIEL BURCH, CeNeRx Biopharma

DENNIS CHOI, Simons Foundation

TIMOTHY COETZEE, National Multiple Sclerosis Society

DAVID COHEN, Columbia University

JOHN DUNLOP, Pfizer, Inc.

EMMELINE EDWARDS, NIH Neuroscience Blueprint

RICHARD FRANK, GE Healthcare, Inc.

MYRON GUTTMAN, National Science Foundation

RICHARD HODES, National Institute on Aging

KATIE HOOD, Michael J. Fox Foundation for Parkinson’s Research

STEVEN E. HYMAN, Harvard University

THOMAS INSEL, National Institute of Mental Health

DANIEL JAVITT, New York University

STORY LANDIS, National Institute of Neurological Disorders and Stroke

HUSSEINI MANJI, Johnson & Johnson Pharmaceutical Research and Development, LLC

EVE MARDER, Brandeis University

DAVID MICHELSON, Merck Research Laboratories

JONATHAN MORENO, University of Pennsylvania School of Medicine

KATHIE OLSEN, ScienceWorks, LLC

ATUL PANDE, GlaxoSmithKline, Inc.

MENELAS PANGALOS, Pfizer Inc.

STEVEN PAUL, Weill Cornell Medical College

WILLIAM POTTER, FNIH Neuroscience Biomarker Steering Committee

PAUL SIEVING, National Eye Institute

RAE SILVER, Columbia University

JUDITH SIUCIAK, Foundation for the National Institutes of Health

MARC TESSIER-LEVIGNE, The Rockefeller University

WILLIAM THIES, Alzheimer’s Association

    image

* Institute of Medicine forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

NORA VOLKOW, National Institute on Drug Abuse

KENNETH WARREN, National Institute on Alcohol Abuse and Alcoholism

DOUG WILLIAMSON, Lilly Research Laboratories

FRANK YOCCA, AstraZeneca Pharmaceuticals

STEVIN ZORN, Lundbeck USA

CHARLES ZORUMSKI, Washington University School of Medicine

IOM Staff

BRUCE M. ALTEVOGT, Forum Director

DIANA E. PANKEVICH, Program Officer

ELIZABETH THOMAS, Senior Program Assistant

ANDREW POPE, Director, Board on Health Sciences Policy

Page viii Cite
Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

Reviewers

This report has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise, in accordance with procedures approved by the National Research Council’s Report Review Committee. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this report:

Floyd Bloom, The Scripps Research Institute

Barbara Davies, Understanding Animal Research

Sharon Juliano, Uniformed Services University of the Health Sciences

Emily McIvor, Humane Society International

Robert Wurtz, National Eye Institute

Stuart Zola, Yerkes Regional Primate Research Center

Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the report before its release. The review of this report was overseen by Caswell Evans, associate dean of the College of Dentistry, University of Illinois at Chicago, and Joseph T. Coyle, Eben S. Draper Professor of Psychiatry and of Neuroscience, Harvard Medical School. Appointed by the Institute of

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
×

Medicine, they were responsible for making certain that an independent examination of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the authoring committee and the institution.

Suggested Citation:"Front Matter." Institute of Medicine and National Research Council. 2012. International Animal Research Regulations: Impact on Neuroscience Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/13322.
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Animals are widely used in neuroscience research to explore biological mechanisms of nervous system function, to identify the genetic basis of disease states, and to provide models of human disorders and diseases for the development of new treatments. To ensure the humane care and use of animals, numerous laws, policies, and regulations are in place governing the use of animals in research, and certain animal regulations have implications specific to neuroscience research.

To consider animal research regulations from a global perspective, the IOM Forum on Neuroscience and Nervous System Disorders, in collaboration with the National Research Council and the Institute for Laboratory Animal Research, held a workshop in Buckinghamshire, UK, July 26-27, 2011. The workshop brought together neuroscientists, legal scholars, administrators, and other key stakeholders to discuss current and emerging trends in animal regulations as they apply to the neurosciences. This document summarizes the workshop.

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