Abelson, P. H. 1992. Diet and cancer in humans and rodents. Science 225:141. (Editorial)
Ader, R. 1967. The influence of psychological factors on disease susceptibility in animals. Pp. 219–238 in Husbandry of Laboratory Animals, M. L. Conalty, ed. London: Academic Press.
Allred, J. B., and G. G. Berntson. 1986. Is euthanasia of rats by decapitation inhumane? J. Nutr. 116:1859–1861.
Amyx, H. L. 1987. Control of animal pain and distress in antibody production and infectious disease studies. J. Am. Vet. Med. Assoc. 191(10):1287–1289.
Anand, K. J. S., D. Phil, and P. R. Hickey. 1987a. Pain and its effects in the human neonate and fetus. N. Eng. J. Med. 317(21):1321–1329.
Anand, K. J. S., W. G. Sippell, and A. Aynsley-Green. 1987b. Randomized trial of fentanyl anesthesia in preterm babies undergoing surgery: Effects on the stress response. Lancet 1:243–248.
Antin, J., J. Gibbs, J. Holt, R. C. Young, and G. P. Smith. 1975. Cholecystokinin elicits the complete behavioral sequence of satiety in rats. J. Comp. Physiol. Psychol. 89:784–790.
Archer, J. 1970. Effects of population density on behavior in rodents. Pp. 169–210 in Social Behavior in Birds and Mammals, J. H. Crook, ed. New York: Academic Press.
Arena, P. C., and K. C. Richardson. 1990. The relief of pain in cold-blooded vertebrates. Australian Council for the Care of Animals in Research and Teaching (ACCART) News 3(1):1–4.
Arluke, A. 1990. Uneasiness among laboratory technicians. Lab Anim. 19(4):20–39.
AVMA (American Veterinary Medical Association). 1986. 1986 Report of the AVMA Panel on Euthanasia. J. Am. Vet. Med. Assoc. 188(3):252–268.
Bahga, H. S., and R. P. Link. 1966. Cardiovascular effects of two phenothiazines: Fluphenazine and trifluoperazine. Am. J. Vet. Res. 27:81.
Barclay, R. J., W. J. Herbert, and T. B. Poole. 1988. The Disturbance Index: A Behavioral Method for Assessing the Severity of Common Laboratory Procedures on Rodents. Hertfordshire, UK: Universities Federation for Animal Welfare. 35 pp.
Bayne, K., H. Mainzer, S. Dexter, G. Campbell, F. Yamada, and S. Suomi. 1991. The reduction of abnormal behaviors in individually housed rhesus monkeys (Macaca mulatta) with a foraging/grooming board. Am. J. Primatol. 23(1):23–35.
Beaver, B. V. 1989. Environmental enrichment for laboratory animals. ILAR News 31(2):5–13.
Benson, G. J., and J. C. Thurmon. 1979. Anesthesia of swine under field conditions. J. Am. Vet. Med. Assoc. 194:594.
Berlyne, D. E. 1960. Conflict, Arousal and Curiosity. New York: McGraw-Hill. 350 pp.
Berson, B., G. Bernston, E. Zipf, M. Torello, and W. Kirk. 1983. Vasopressin-induced antinociception: An investigation into its physiological and hormonal basis. Endocrinology 113:337–343.
Bertram, B. C. R. 1978. Living in groups: Predators and prey. Pp. 64–96 in Behavioral Ecology: An Evolutionary Approach, 1st ed., J. R. Krebs, and N. B. Davies, eds. Sunderland, Mass.: Sinauer.
Bloom, K. R., and M. Cook. 1989. Environmental enrichment: Behavioral responses of rhesus to puzzle feeders. Lab Anim. 18(4):25–31.
Bloomsmith, M. 1989. Feeding enrichment for captive great apes. Pp. 336–356 in Housing, Care and Psychological Well-Being of Captive and Laboratory Primates, E. F. Segal, ed. Park Ridge, N.J.: Noyes Publications .
Bloomstrand, M. 1987. An analysis of feeding enrichment for captive chimpanzees. Diss. Abstr. Int. 48(5-B):1545.
Boccia, M. L. 1989. Long-term effects of a natural foraging task on aggression and sterotypies in socially housed pigtail macaques. Lab. Primate Newsl. 28(2):18–19.
Bonner, W. B., M. E. Keeling, E. T. Van Ormer, and J. E. Haynie. 1972. Ketamine anesthesia in chimpanzees and other great ape species. The Chimpanzee 5:255–268.
Booij, L. H. D. J., R. P. Edwards, Y. J. Sohn, R. D. Miller. 1980. Comparative cardiovascular and neuromuscular effects of ORG NC45, pancuronium, metocurine and d-tubocurarine. Anesth. Anagl. (Cleveland) 19:26–30.
Booth, N. H., and L. E. McDonald, eds. 1982. Non-narcotic analgesics. Pp. 297–320 in Veterinary Pharmacology and Therapeutics, 5th ed. Ames: Iowa State University Press.
Bowd, A. D. 1980. Ethics and animal experimentation. Am. Psychol. 35:224–225.
Breazile, J. E. 1987. Physiologic basis and consequences of distress in animals . J. Am. Vet. Med. Assoc. 191(10):1212–1215.
Breese, C. E., and N. H. Dodman. 1984. Xylazine-ketamine-oxymorphone: An injectable anesthetic combination in swine. J. Am. Vet. Med. Assoc. 184:182–183.
Breland, K., and M. Breland. 1961. The misbehavior of organisms. Am. Psychol. 16:681–684.
Brown, L. A. 1988. Anesthesia in Fish. Vet. Clin. N. Am. 18(2):317–330.
Bustad, L. K. 1982. An educator's approach to euthanasia. Lab Anim. 11(4):37–41.
Calderwood, H. W., A. M. Klide, B. B. Cohn, and L. R. Soma. 1971. Cardiorespiratory effects of tiletamine in cats. Am. J. Vet. Res. 32(10):1511–1515.
Cannon, W. B. 1929. Bodily Changes in Pain, Hunger, Fear and Rage: An account of recent researches into the function of emotional excitement. New York: Appleton. 404 pp.
Cass, N. W., A. Brown, K. C. Ng, and D. G. Lampard. 1980. Dosage patterns of non-depolarizing neuromuscular blockers in the sheep. Anesth. Intens. Care 8:13–15.
CCAC (Canadian Council on Animal Care). 1980. Guide to the Care and Use of Experimental Animals. Vol. 1. Ontario, Canada: Canadian Council on Animal Care. 120 pp.
CFR (Code of Federal Regulations), Title 9 (Animals and Animal Products), Subchapter A (Animal Welfare), Parts 1–3. Copies available from: Animal Care Staff, Regulatory Enforcement and Animal Care, APHIS, USDA, Federal Building, Room 268, Hyattsville, MD 20782.
Chamove, A. S., and J. R. Anderson. 1988. Impact of feeding practices on growth and behavior of stump-tailed macaques (Macaca arctoides). Bull. Soc. Herpetol. France 11:231–246.
Chamove, A. S., J. G. Anderson, S. C. Morgan-Jones, and S. P. Jones. 1982. Deep woodchip
litter: Hygiene, feeding, and behavioral enhancement in eight primate species. Int. J. Study Anim. Prob. 3:308–318.
Chen, G. 1973. Sympathomimetic anesthetics. Can. Anesth. Soc. J. 20(2):180–185.
Clarke, K. W., and L. W. Hall. 1969. ''Xylazine"—A new sedative for horses and cattle. Vet. Rec. 8:512–517.
Clifford, D. H. 1957. Effect of preanesthetic medication with chlorpromazine, meperidine and promazine on pentobarbital anesthesia in the cat. J. Am. Vet. Med. Assoc. 156:415–418.
Clifford, D. H. 1984. Preanesthesia, anesthesia, analgesia and euthanasia. Pp. 527–562 in Lab. Anim. Med., J. G. Fox, B. J. Cohen, and F. M. Loew, eds. Orlando, Fla.: Academic Press.
Collette, W. L., and W. F. Meriwether. 1965. Some changes in the peripheral blood of dogs after administration of certain tranquilizers and narcotics. Vet. Med./Small Anim. Clinic 60:1223.
Conahan, S. T., and W. H. Vogel. 1986. The effect of diazepam administration on heart rate and mean arterial blood pressure in resting and stressed conscious rats. Res. Commun. Chem. Pathol. Pharmacol. 53(3):301–317.
Connolly, R., and F. W. Quimby. 1978. Acepromazine-ketamine anesthesia in the rhesus monkey (Macaca mulatta). Lab. Anim. Sci. 28:72–74.
Cooper, B. Y., and C. J. Vierck, Jr. 1986. Vocalizations as measures of pain in monkeys. Pain 26(3):393–407.
Copland, V. S., S. C. Haskins, and J. D. Patz. 1987. Oxymorphone: Cardiovascular, pulmonary, and behavioral effects in dogs. Am. J. Vet. Med. Res. 48(11):1626–1630.
Covino, B. G., H. A. Fozzard, K. Rehder, eds. 1985. Effects of Anesthesia: Clinical Physiology Series. Bethesda, Md.: American Physiological Society. 224 pp.
Crane, S. W. 1987. Perioperative analgesia: A surgeon's perspective. J. Am. Vet. Med. Assoc. 191:1254–1257.
Cronin, G. M., P. R. Wiepkema, and J. M. van Ree. 1986. Endorphins implicated in stereotypes on tethered sows. Experientia 42(2):198–199.
Cullen, L. K., and R. S. Jones. 1977. Clinical observations on xylazine-ketamine anesthesia in the cat. Vet. Rec. 101:115–116.
Curl, J. L., and L. L. Peters. 1983. Ketamine hydrochloride and xylazine hydrochloride anesthesia in the golden hamster (Mesocricetus auratus). Lab. Anim. 17:290–293.
Dahlstrom, B. E., L. K. Paalzow, C. Lindberg, and C. Bogentoft. 1979. Pharmacokinetics and analgesic effect of pethidine (meperidine) and its metabolites in the rat. Drug Metab. Dispos. 7(2):108–112.
Daly, M. 1973. Early stimulation of rodents: A critical review of present interpretations. Br. J. Psy. 64:435–460.
Dantzer, R. 1986. Behavioral, physiological and functional aspects of stereotyped behavior: A review and re-interpretation. J. Anim. Sci. 62(6):1776–1786.
Dawkins, M. S. 1976. Towards an objective method of assessing welfare in domestic fowl. Appl. Anim. Ethol. 2(3):245–254.
Dawkins, M. S. 1983. Battery hens name their price: Consumer demand theory and the measurement of ethological "needs". Anim. Behav. 31:1195–1205.
Dawkins, M. S. 1990. From an animal's point of view: Motivation, fitness and animal welfare. Behav. Brain Sci. 13:1–61.
Denenberg, V. 1969. The Effects of early experience. Pp. 95–130 in Behavior of Domestic Animals, E. S. E. Hafez, ed. Baltimore, Md.: Williams & Wilkins.
Dennis, M. B. Jr., W. K. Dong, K. A. Weisbrod, and C. A. Elchlepp. 1988. Use of captive bolt as a method of euthanasia in larger laboratory animal species. Lab. Anim. Sci. 38(4):459–462.
Denny, H. R., and J. N. Lucke. 1977. Anesthetic and surgical technique for bilateral adrenalectomy in stress sensitive pigs. Res. Vet. Sci. 23:372–377.
DiGregorio, G. 1990. The effects of woodchips and buried food on behavior patterns and psychological well-being of captive rhesus monkeys. Diss. Abstr. Int. 50(12B):5924.
Dodman, N. H., L. Shuster, M. H. Court, and R. Dixon. 1987. Investigation into the use of narcotic antagonists in the treatment of a stereotypical behavior pattern (crib biting) in the horse. Am. J. Vet. Res. 48(2):311–319.
Dodman, N. H., G. H. Clark, M. H. Court, L. L. Fikes, and R. J. Boudrieau. 1992. Epidural opioid administration for postoperative pain relief in the dog. pp. 274–277 in Animal Pain, C. E. Short and A. Van Poznak, eds. New York: Churchill Livingstone, Inc.
Draisci, G., and M. J. Iadarola. 1989. Temporal analysis of increases in C-fos, preprodynorphin and preproenkephalin mRNAs in rat spinal cord . Brain Res. 6(1):31–37.
Dresser, R. 1988. Assessing harm and justification in animal research: Federal policy opens the laboratory door. Rutgers Law Rev. 40(3):723–795.
Dubner, R. 1985. Specialization in nociceptive pathways: Sensory discrimination, sensory modulation and neural connectivity. Pp. 111–137 in Advances in Pain Research and Therapy, vol. 9, H. L. Fields, R. Dubner, and F. Cervero, eds. New York: Raven Press.
Dubner, R. 1987. Research on pain mechanisms in animals. J. Am. Vet. Med. Assoc. 191(10):1273–1276.
Dubner, R., and G. J. Bennett. 1983. Spinal and trigeminal mechanisms of nociception. Ann. Rev. Neurosci. 6:381–418.
Dubner, R., B. Sessle, and A. T. Storey. 1978. The Neural Basis of Oral and Facial Function. New York: Plenum Press. 483 pp.
Dubner, R., D. R. Kenshalo, Jr., W. Maixner, M. C. Bushnell, and J. L. Oliveras. 1989. The correlation of monkey medullary dorsal horn neuronal activity and the perceived intensity of noxious heat stimuli. J. Neurophysiol. 62(2):450–457.
Durant, N. N., M. C. Houwertjes, J. F. Crul. 1980. Comparison of the neuromuscular blocking properties of ORG NC45 and pancuronium in the rat, cat and rhesus monkey. Br. J. Anesth. 52:723–730.
Durant, N. N., I. G. Marshall, D. S. Savage. 1979. The neuromuscular and autonomic blocking activities of pancuronium analogues, in the cat. J. Pharm. Pharmacol. 31:831–836.
Eberhardson B., G. Olsson, L. E. Appelgren, and S. O. Jacobson. 1979. Pharmacokinetic studies of phenylbutazone in cattle. J. Vet. Pharmacol. Ther. 2:31–37.
Eger, E. I. 1978. MAC. Pp. 1–25 in Anesthetic Uptake and Action, E. E. I. Eger, ed. Baltimore, Md.: Williams & Wilkins.
Eger, E. I. II, L. J. Saidman, and B. Brandstater. 1965. Minimum alveolar anesthetic concentration: A standard of anesthetic potency. Anesthesiology 26:756–763.
Eisemann, C. H., W. K. Jorgenson, D. J. Merritt, M. J. Rice, B. W. Cribb, P. D. Webb, and M. P. Zalucki. 1984. Do insects feel pain?—A biological review. Experientia 40:164–167.
Fajzi, K., V. Reinhardt, and M. D. Smith. 1989. A review of environmental enrichment strategies for singly caged nonhuman primates. Lab. Anim. 18(2):23–35.
Fentress, J. C. 1973. Specific and nonspecific factors in the causation of behavior. Pp. 155–224 in Perspectives in Ethology, vol. 1, P. P. G. Bateson and P. H. Klopfer, eds. New York: Plenum Press.
Field, W. E., J. Yelnosky, J. Mundy, and J. Mitchell. 1966. Use of droperidol and fentanyl for analgesia and sedation in primates. J. Am. Vet. Med. Assoc. 149(7):896–901.
Finley, R. S. 1990. Pain management with spinally administered opioids. Am. J. Hosp. Pharm. 47:S14–S17.
Fiorito, G. 1986. Is there pain in invertebrates? Behav. Processes 12:383–388.
Flecknell, P. A. 1984. The relief of pain in laboratory animals. Lab. Anim. 18(2):147–160.
Flecknell, P. A. 1985. Recognition and alleviation of pain in animals. Pp. 61–77 in Advances in Animal Welfare Science. Boston, Mass.: Martinus Nijholt.
Flecknell, P. A. 1987. Laboratory Animal Anesthesia. London: Academic Press. 156 pp.
Flecknell, P. A., J. H. Liles, and R. Wootton. 1989. Reversal of fentanyl/fluanisone neuroleptanalgesia in the rabbit using mixed agonist/antagonist opioids. Lab. Anim. 23:147–155.
Gantt, W. H., J. E. O. Newton, F. L. Royer, and J. H. Stephens. 1966. Effect of person. Cond. Reflex 1:18–35.
Gärtner, K., C. Büttner, K. Döhler, R. Friedel, J. Lindena, and I. Trautschold. 1980. Stress response of rat to handling and experimental procedures. Lab. Anim. (England) 14:267–274.
Gilman, A. G., T. W. Rall, A. S. Nies, and P. Taylor. 1990. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. New York: Pergamon Press. 1811 pp.
Gleed, R. D. 1987. Tranquilizers and sedatives. Pp. 16–27 in Principles and Practice of Veterinary Anesthesia, C. E. Short, ed. Baltimore, Md.: Williams & Wilkins.
Goldstein, D. 1987. Stress-induced activation of the sympathetic nervous system. Bailliere's Clin. Endocrinol. Metab. 1:253–278.
Gracely, R. H., P. McGrath, and R. Dubner. 1978. Ratio scales of sensory and affective verbal pain descriptors. Pain 5:5–18.
Graham-Jones, O. 1960. Tranquilizer and paralytic drugs: An international survey of animal restraint techniques. Int. Zoo Yearb. 2:300.
Graham-Jones, O. 1964. Restraint and anesthesia of some captive wild mammals. Vet. Rec. 76:1216.
Green, C. J. 1975. Neuroleptanalgesic drug combinations in the anesthetic management of small laboratory animals. Lab. Anim. 9:161–178.
Green, C. J. 1978. The prevention of apprehension and pain in experimental animals. Pp. 116–124 in The Reduction and Prevention of Suffering in Animal Experiments. Proceedings of the Royal Society for the Prevention of Cruelty to Animals Symposium. London.
Green, C. J., J. Knight, S. Precious, and S. Simpkin. 1981a. Metomidate, etomidate, and fentanyl as injectable anesthetic agents in mice. Lab. Anim. 15:171–175.
Green, C. J., J. Knight, S. Precious, and S. Simpkin. 1981b. Ketamine alone and combined with diazepam or xylazine in laboratory animals: A 10 year experience. Lab. Anim. 15:163–170.
Greenstein, E. T. 1975. Ketamine HCl, a dissociative anesthetic for squirrel monkeys (Saimiri sciureus). Lab. Anim. Sci. 25(6):774–777.
Gregg, R. 1989. Spinal analgesia. Anesthesiology Clinics N. Am. 7:79–100.
Hansen, B., E. Hardie, and M. Young. 1990. Recognition of acute pain and distress in the dog. Humane Innovations and Alternatives in Animal Experimentation 4:170–172.
Hardie E. M, G. E. Hardee, and C. A. Rawlings. 1985. Pharmacokinetics of flunixin meglumine in dogs. Am. J. Vet. Res. 46(1):235–237.
Hardy, J. D., H. G. Wolff, and H. Goodell. 1952. Pain Sensation and Reactions. Baltimore, Md.: Williams & Wilkins. 435 pp.
Hargreaves, K. M., and R. Dubner. 1991. Mechanisms of pain and analgesia. In Management of Pain and Anxiety in Dental Practice, R. Dionne and J. Phero, eds. New York: Elsevier. In press.
Hargreaves, K., R. Dionne, and G. Mueller. 1983. Plasma beta endorphin-like immunoreactivity, pain and anxiety following administration of placebo in oral surgery patients. J. Dent. Res. 62:1170–1173.
Hargreaves, K. M., G. P. Mueller, R. Dubner, D. Goldstein, and R. A. Dionne. 1987. Corticotropin-releasing factor (CRF) produces analgesia in humans and rats. Brain Res. 422(1):154–157.
Hargrove, J. C., J. E. Heavner, R. D. Guthrie, and W. R. Morton. 1980. Age dependent ketamine pharmacodynamics in the pigtail monkey (Macaca nemestrina). Proc. West. Pharmacol. Soc. 23:129–133.
Harkness, J. E., and J. E. Wagner. 1983. The Biology and Medicine of Rabbit and Rodents, 2nd ed. Philadelphia, Pa.: Lea and Febiger. 55 pp.
Hartsfield, S. M. 1987. Machines and breathing systems for administration of inhalation anesthetics. Pp. 395–418 in Principles and Practice of Veterinary Anesthesia, C. E. Short, ed. Baltimore, Md.: Williams & Wilkins.
Harvey, R. C. and J. Walberg. 1987. Special considerations for anesthesia and analgesia in research animals. Pp. 380–392 in Principles and Practice of Veterinary Anesthesia, C. E. Short, ed. Baltimore, Md.: Williams & Wilkins.
Heavner, J. E. 1970. Morphine for postsurgical use in cats. J. Am. Vet. Med. Assoc. 156:1018.
Hediger, H. 1955. Studies on the Psychology and Behavior of Captive Animals in Zoos and Circuses. London: Butterworths Scientific Publications.
Hellyer, P., W. W. Muir, J. A. E. Hubbell, and J. Sally. 1988. Cardiorespiratory effects of the intravenous administration of tiletamine-zolazepam to cats. Vet. Surg. 17(2):105–110.
Hennessy, J. W., and S. Levine. 1979. Stress, arousal, and the pituitary-adrenal system: A psychoendocrine hypothesis. Pp. 134–178 in Progress in Psychobiology, J. M. Sprague and A. N. Epstein, eds. New York: Academic Press.
Higgins, A. J. 1985. The biology, pathophysiology and control of eicosanoids in inflammation. J. Vet. Pharmacol. Ther. 8(1):1–18.
Hildebrand, S. V., and G. A. Howitt. 1984. Dosage requirement of pancuronium in halothaneanesthetized ponies: A comparison of cumulative and single-dose administration. Am. J. Vet. Res. 45:2441–2444.
Hobbs, B. A., T. G. Rolhall, T. L. Sprenkel, and K. L. Anthony. 1991. Comparison of several combinations for anesthesia in rabbits. Am. J. Vet. Res. 5:669–674.
Hofer, M. A. 1978. Hidden regulatory processes in early social relationships. Pp. 135–166 in Perspectives in Ethology: Social Behavior, vol. 3, P. P. G. Bateson and P. H. Klopfer, eds. New York: Plenum Press.
Hoffman, P. E. 1974. Clinical evaluation of xylazine as a chemical restraining agent, sedative, and analgesic in horses. J. Am. Vet. Med. Assoc. 164(1):42–45.
Holzgrefe, H. H., J. M. Everitt, and E. M. Wright. 1987. Alpha-chloralose as a canine anesthetic. Lab. Anim. Sci. 37(5):587–595.
Hopkins, T. J. 1972. Clinical pharmacology of xylazine in cattle. Austral. Vet. J. 48:109–112.
Hosobuchi, Y., J. E. Adams, and R. Linchitz. 1977. Pain relief by electrical stimulation of the central gray matter in humans and its reversal by naloxone. Science 197:183–186.
Houdeshell J. W, and P. W. Hennessey. 1977. A new nonsteroidal, anti-inflammatory analgesic for horses. J. Equine Med. Surg. 1:57–63.
Hughes, B. O., and I. W. H. Duncan. 1988. The notion of ethological "need", models of animal motivation and animal welfare. Anim. Behav. 36:1696–1707.
Hughes, H. C. 1981. Anesthesia of laboratory animals. Lab. Anim. 10:40–56.
Hughes, H. C., W. J. White, and C. M. Lang. 1975. Guidelines for the use of tranquilizers, anesthetics, and analgesics in laboratory animals. Vet. Anesth. 2:19–24.
Hughes, H. C., and C. M. Lang. 1983. Control of pain in dogs and cats. Pp. 207–216 in Animal Pain: Perception and Alleviation. R. L. Kitchell, H. H. Erickson, eds. Bethesda, Md.: American Physiological Society.
Hughes, R., and D. J. Chapple. 1976. Effects of non-depolarizing neuromuscular blocking agents on peripheral autonomic mechanisms in cats. Br. J. Anesth. 48:59–68.
Hylden, J. L., F. Anton, and R. L. Nahin. 1989. Spinal lamina I projection neurons in the rat: Collateral innervation of parabrachial area and thalamus. Neuroscience 28(1):27–37.
Iadarola, M. J., L. S. Brady, G. Draisci, and R. Dubner. 1988. Enhancement of dynorphin gene expression in spinal cord following experimental inflammation: Stimulus specificity, behavioral parameters and opioid receptor binding. Pain 35(3):313–326.
IRAC (Interagency Research Animal Committee). 1985. U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. 1985. Prepared by the Interagency Research Animal Committee, National Institutes of Health
(Lead). Pp 81–83 in Guide for the Care and Use of Laboratory Animals. NIH Publication No. 85-23. Washington, D.C.: U. S. Department of Health and Human Services.
Jenkins, W. L. 1987. Pharmacologic aspects of analgesic drugs in animals: An overview. J. Am Vet. Assoc. 191(10):1231–1240.
Jones, J. B., and M. L. Simmons. 1968. Innovar-Vet.® as an intramuscular anesthetic for rats. Lab. Anim. Care 18(6):642–643.
Joris, J., R. Dubner, and K. Hargreaves. 1987. Opioid analgesia at peripheral sites: A target for opioids released during stress and inflammation? Anesth. Analg. 66:1277–1281.
Kaka, J. S., P. A. Klavano, and W. L. Hayton. 1979. Pharmacokinetics of ketamine in the horse. Am. J. Vet. Res. 40(7):978–981.
Kalpravidh, M., W. V. Lumb, M. Wright, and R. B. Heath. 1984. Analgesic effects of butorphanol in horses: Dose-response studies. Am. J. Vet. Res. 45(2):211–216.
Kamerling, S. G., W. M. Cravens, and C. A. Bagwell. 1988. Objective assessment of detomidine-induced analgesia and sedation in the horse. Eur. J. Pharm. 151(1):1–8.
Kenshalo, D. R., Jr., E. H. Chudler, F. Anton, and R. Dubner. 1988. SI nociceptive neurons participate in the encoding process by which monkeys perceive the intensity of noxious thermal stimulation. Brain Res. 454(1–2):378–382.
Kisloff, B. 1975. Ketamine-paraldehyde anesthesia for rabbits. Am. J. Vet. Res. 36(7):1033–1034.
Kitchell, R. L., H. H. Erickson, E. Carstens, and L. E. Davis, eds. 1983. Animal Pain: Perception and Alleviation. Bethesda, Md.: American Physiological Society. 221 pp.
Kitchell, R. L., and R. D. Johnson. 1985. Assessment of Pain in Animals. Pp. 113–140 in Animal Stress, G. P. Moberg, ed. Bethesda, Md.: American Physiological Society.
Kitchen, H., A. Aronson, J. L. Bittle, C. W. McPherson, D. B. Morton, S. P. Pakes, B. Rollin, A. N. Rowan, J. A. Sechzer, J. E. Vanderlip, J. A. Will, A. S. Clark, and J. S. Gloyd. 1987. Panel report of the colloquium on recognition and alleviation of animal pain and distress. J. Am. Vet. Med. Assoc. 191(10):1186–1191.
Klein, L. 1987. Neuromuscular Blocking Agents. Pp. 134–153 in Principles and Practice of Veterinary Anesthesia, C. E. Short, ed. Baltimore, Md.: Williams & Wilkins.
Klein, L., and C. Baetjer. 1974. Preliminary report: Xylazine and morphine sedation in the horse. Vet. Anesth. 2:2–4.
Klein, L., J. Hopkins, and H. Rosenberg. 1983. Different relationship of train-of-four to twitch and tetanus for vecuronium, pancuronium and gallamine. Anesthesiology. 59:A275.
Klein, L., T. Sylvina, and E. Beck. 1985. Neuromuscular blockade with d-tubocurarine, pancuronium and vecuronium in halothane anesthetized sheep. Proc. 2nd Intl. Cong. Vet. Anes. Oct:174 (abstract).
Klemm, W. R. 1976. Use of the immobility reflex ("animal hypnosis") in neuropharmacological studies. Pharmacol. Biochem. Behav. 4:85–94.
Klide, A. M. 1989. An hypothesis for the prolonged effect of acupuncture. Acupuncture Electrother. Res. 14(2):141–147.
Klide, A. M., and B. B. Martin. 1989. Methods of stimulating acupuncture points for treatment of chronic back pain in horses. J. Am. Vet. Med. Assoc. 195:1375–1379.
Klide, A. M., H. W. Calderwood, and L. R. Soma. 1975. Cardiopulmonary effects of xylazine in dogs. Am. J. Vet. Res. 36(7):931–935.
Kohn, C. W., and W. W. Muir. 1988. Selected aspects of the clinical pharmacology of visceral analgesics and gut motility modifying drugs in the horse. J. Vet. Intern. Med. 2(2):85–91.
Kolata, R. J., and C. A Rawlings. 1982. Cardiopulmonary effects of intravenous xylazine, ketamine, and atropine in the dog. Am. J. Vet. Res. 43(12):2196–2198.
Kruckenburg, S. M. 1979. Drugs and dosages. Appendix 2 in The Laboratory Rat, vols. 1 and 2, H. J. Baker, J. R. Lindsey, and S. H. Weisbroth, eds. London: Academic Press.
Landi, M., J. W. Krieder, C. M. Lang and L. P. Bullock. 1982. Effects of shipping on the immune function of mice. Am. J. Vet. Res. 43:1654–1657.
Latané, B., and D. Hothersall. 1972. Social attraction in animals. Pp. 259–275 in New Horizons in Psychology 2, P. C. Dodwell, ed. London: Penguin Books.
Leash, A. M., R. D. Beyer, and R. G. Wilber. 1973. Self-mutilation following Innovar-Vet.® injection in the guinea pig. Lab. Anim. Sci. 23:720–721.
Lefebvre, L., and G. Carli. 1985. Parturition in nonhuman primates: Pain and auditory concealment . Pain 21(4):315–327.
Levine, S. A. 1985. A definition of stress? Pp. 51–70 in Animal Stress, G. Moberg, ed. Bethesda, Md.: American Physiological Society.
Lewis, G. E., Jr., and P. J. Jennings, Jr. 1972. Effective sedation of laboratory animals using Innovar-Vet.® Lab. Anim. Sci. 22:430–432.
Lin, H. C., J. C. Thurmon, G. J. Benson, W. J. Tranquilli, and W. A. Olson. 1989. The hemodynamic response of calves to tiletamine-zolazepam anesthesia. Vet. Surg. 18(4):328–334.
Lindberg, D., and A. Smith. 1988. Organoleptic factors in animal feeding. Zoonooz. 61(12):14–15.
Line, S. W. 1987. Environmental enrichment for laboratory primates. J. Am. Vet. Med. Assoc. 190(7):854–859.
Line, S. W., and P. Houghton. 1987. Influence in an environmental enrichment device on general behavior and appetite in rhesus macaques. Lab. Anim. Sci. 37(4):508.
Lowe, J. E. 1969. Pentazocine (Talwin-V) for the relief of abdominal pain in ponies—A comparative evaluation with description of a colic model for analgesia evaluation. Proc. Am. Assoc. Equine Prac. Proc. Dec:31–46.
Ludders, J. W. 1992. Pharmacokinetics and the use of animals in research. Pp. 318–322 in Animal Pain, C. E. Short, A. Van Poznak, eds. New York: Churchill Livingstone.
Lumb, W. V. 1974. Euthanasia by noninhalant pharmacologic agents. J. Am. Vet. Med. Assoc. 165:851–852.
Lumb, W. V., and E. W. Jones. 1984. Veterinary Anesthesia. Philadelphia: Lea & Febiger. 693 pp.
Lumb, W. V., and A. F. Moreland. 1982. Chemical methods for euthanasia. Lab Anim. 11(4):29–35.
Maki, S., P. L. Alford, M. A. Bloomsmith, and J. Franklin. 1989. Food puzzle device simulating termite fishing for captive chimpanzees (Pan troglodytes). Am. J. Primatol. 1:71–78.
Malis, J. L. 1973. Analgesic testing in primates. Pp. 206–209 in Agonist and Antagonist Actions of Narcotic Analgesic Drugs, H. W. Kosterlitz, H. O. J. Collier, and J. E. Villarreal, eds. Baltimore, Md.: University Park Press.
Manley S. V., E. P. Steffey, G. A. Howitt, and M. Woliner. 1983. Cardiovascular and neuromuscular effects of pancuronium bromide in the pony. Am. J. Vet. Res. 44:1349–1353.
Markowitz, H. 1978. Engineering environments for behavioral opportunities in the zoo. Behav. Anal. Spring:34–47.
Markowitz, H. 1982. Behavioral Enrichment in the Zoo. New York: Van Nostrand Reinhold.
Marsboom, R., J. Mortelmans, J. Vercruysse, and D. Thienpont. 1962. Effect of sedation in gorillas and chimpanzees. Nord. Vet. Med. 14(1):95–101.
Marsboom, R., J. Mortelmans, and J. Vercruysse. 1963. Neuroleptanalgesia in monkeys. Vet. Rec. 75:132–133.
Martin, W. R. 1984. Pharmacology of opioids. Pharmacol. Rev. 35(4):283–323.
Mason, W. A. 1965. Determinants of social behavior in young chimpanzees. Pp. 335–364 in Behavior of Nonhuman Primates, Vol. 2, A. M. Schrier, H. F. Harlow, and F. Stollnitz, eds. New York: Academic Press.
Mason, W. A. 1967. Motivational aspects of social responsiveness in young chimpanzees. Pp. 103–126 in Early Behavior: Comparative and Developmental Approaches, H. W. Stevenson, E. H. Hess, and H. Rheingold, eds. New York: John Wiley & Sons, Inc.
Mason, W. A., and J. P. Capitanio. 1988. Formation and expression of filial attachment in
rhesus monkeys raised with living and with inanimate mother substitutes. Dev. Psychol. 21(5):401–430.
Mayer, D. J., and D. D. Price. 1976. Central nervous systems of analgesia. Pain 2:379–404.
Mayer, D. J., T. W. Wolfle, H. Akil, B. Carder, and J. Liebeskind. 1971. Analgesia from electrical stimulation in the brainstem of the rat. Science 174:1351–1354.
Mazue, G., P. Richez, and J. Berthe. 1982. Pharmacology and comparative toxicology of nonsteroidal anti-inflammatory agents. Pp. 321–331 in Veterinary Pharmacology and Toxicology, Y. Ruckenbusch, P. L. Toutain, and G. D. Koritz, eds. Boston, Mass.: MTP.
McCormick, M. J., and M. A. Ashworth. 1971. Acepromazine and methoxyflurane anesthesia of immature New Zealand White Rabbits. Lab. Anim. Sci. 21(2):220–223.
Medway, Lord. 1980. Report of the Panel of Enquiry into Shooting and Angling. c/o Causeway, Horsham, Sussex, RH12 1HG, England.
Melzack, R., and P. D. Wall. 1965. Pain mechanisms: A new theory. Science 150:971–979.
Melzack, R., and T. H. Scott, 1957. The effects of early experience on the response to pain. J. Comp. Physiol. Psychol. 50:155–161.
Mendoza, S. P., and W. A. Mason. 1986. Contrasting responses to intruders and to involuntary separation by monogamous and polygynous New World monkeys. Physiol. Behav. 38(6):795–801.
Merin, R. G. 1975. Effect of anesthetics on the heart. Surg. Clin. N. Am. 55(4):759–774.
Mersky, H. 1979. Pain terms: A list with definitions and notes on usage. Pain 6:249–250.
Meyer, R. A., J. N. Campbell, and S. N. Raja. 1985. Peripheral neural mechanisms of cutaneous hyperalgesia. Pp. 53–71 in Advances in Pain Research and Therapy, H. L. Fields, R. Dubner, and F. Cervero, eds. New York: Raven Press.
Meyer-Holzapfel, M. 1968. Abnormal behavior in zoo animals. Pp. 476–503 in Abnormal Behavior in Animals, M. W. Fox, ed. Philadelphia: W. B. Saunders Co.
Mikeska, J. A., and W. R. Klemm. 1975. EEG evaluation of humaneness of asphyxia and decapitation euthanasia of the laboratory rat. Lab. Anim. Sci. 25(2):175–179.
Miller, N. E. 1956. Effects of drugs on motivation: The value of using a variety of measures. Ann. N. Y. Acad. Sci. 65:318–333.
Miller, R. D., ed. 1990. Anesthesia, 3rd ed. New York: Churchill Livingston, 115 pp.
Moazed, T. C., and A. V. Wolff. 1988. The raisin board as an environmental enrichment tool for laboratory primates. Lab. Primate Newsl. 27(1):16.
Moberg, G. P. 1987. Problems in defining stress and distress in animals. J. Am. Vet. Med. Assoc. 191(10):1207–1211.
Montgomery, C. A. 1987. Control of animal pain and distress in cancer and toxicologic research. J. Am. Vet. Med. Assoc. 191(10):1277–1281.
Moore, P. K. 1985. Pharmacology, Physiology and Clinical Relevance. New York: Cambridge University Press.
Morgan, R. J., L. B. Eddy, T. N. Solie, and C. C. Turbes. 1981. Ketamine-acepromazine as an anesthetic agent for chinchillas (Chinchilla laniger). Lab Anim. 15:281–283.
Morris, D. 1964. The response of animals to a restricted environment. Symp. Zool. Soc. Lond. 13:99–118.
Morton, D. B., and P. H. M. Griffiths. 1985. Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet. Rec. 116:431–436.
Movshon, J. A. (Chairman). 1988. Anesthesia and paralysis in experimental animals: Report of a workshop held in Bethesda, Maryland, on October 27th, 1984. Visual Neurosci. 1:421–426.
Moye, R. J., A. Pailet, and M. W. Smith. 1973. Clinical use of xylazine in dogs and cats. Vet./Small Anim. Clin. 63:236–241.
Muir, W. W., R. T. Skarda, and W. C. Sheehan. 1979. Hemodynamic and respiratory effects of xylazine-morphine sulfate in horses. Am. J. Vet. Res. 40(10):1417–1420.
Muir, W. W., R. A. Sams, R. H. Huffman, and J. S. Noonan. 1982. Pharmacodynamic and pharmacokinetic properties of diazepam in horses. Am. J. Vet. Res. 43(10):1756–1761.
Muir, W. W., J. A. E. Hubbell, and R. Skarda. 1989. Handbook of Veterinary Anesthesia. St. Louis, Mo.: C.V. Mosby. 340 pp.
Nahin, R. L., J. L. Hylden, M. J. Iadarola, and R. Dubner. 1989. Peripheral inflammation is associated with increased dynorphin immunoreactivity in both projection and local-circuit neurons in the superficial dorsal horn of the rat lumbar spinal cord. Neurosci. Ltrs. 96(3):247–252.
Newton, G., and S. Levine, eds. 1968. Early Experience and Behavior. Springfield: C. C. Thomas. 785 pp.
Nilsson, E., and P. Janssen. 1961. Neuroleptanalgesia: An alternative to general anesthesia. Acta Anesth. Scand. 5:73–78.
Novak, M. A., and S. J. Suomi. 1988. Psychological well-being of primates in captivity. Am. Psychol. 43(10):765–773.
NRC (National Research Council). 1974. Amphibians: Guidelines for the breeding, care, and management of laboratory animals. A report of the Institute of Laboratory Animal Resources Subcommittee on Amphibian Standards, National Research Council, National Academy of Sciences, Washington, D.C.: National Academy Press. 153 pp.
NRC (National Research Council). 1985. Guide for the Care and Use of Laboratory Animals. A report of the Institute of Laboratory Animal Resources Committee on Care and Use of Laboratory Animals. NIH Pub. No. 86-23. Washington, D.C.: U.S. Department of Health and Human Services. 83 pp.
NRC (National Research Council). 1990. Education and Training in the Care and Use of Laboratory Animals: A Guide for Developing Institutional Programs. A report of the Institute of Laboratory Animal Resources Committee on Educational Programs in Laboratory Animal Science, National Research Council, National Academy of Sciences. Washington, D. C.: National Academy Press. 139 pp.
NYAS (New York Academy of Sciences). 1988. Interdisciplinary Principles and Guidelines for the Use of Animals in Research. Testing, and Education. A report of the Ad Hoc Committee on Animal Research. New York: New York Academy of Sciences. 26 pp.
Oliveras, J. L., W. Maixner, R. Dubner, M. C. Bushnell, D. R. Kenshalo, Jr., G. H. Duncan, D. A. Thomas, and R. Bates. 1986. The medullary dorsal horn: A target for the expression of opiate effects on the perceived intensity of noxious heat. J. Neurosci. 6(10):3086–3093.
Orsini, J. A. 1988. Butorphanol tartrate. Pharmacology and clinical indications. Compend. Cont. Educ. 10:849–854.
Owens, C. E., R. Davis, and B. H. Smith. 1981. The psychology of euthanizing animals: The emotional components. Int. J. Stud. Anim. Prob. 2(1):19–26.
Palminteri, A. 1963. Oxymorphone, an effective analgesia in dogs and cats. J. Am. Vet. Med. Assoc. 143:160–163.
Pare, W. P., and G. B. Glavin. 1986. Restraint stress in biomedical research: A review. Neurosci. Biobehav. Rev. 10:339–370.
Paton, W. D. M. 1984. Man and Mouse: Animals in Medical Research. Oxford, N.Y. . : Oxford University Press. 174 pp.
Phifer, C. B, and L. M. Terry. 1986. Use of hypothermia for general anesthesia in preweaning rodents. Physiol. Behav. 38(6):887–890.
Phillips, M. T., and J. A. Sechzer. 1989. Animal Research and Ethical Conflict: An Analysis of the Scientific Literature from 1966–1986. New York: Springer-Verlag.
PHS (Public Health Service). 1986. Public Health Service Policy on Humane Care and Use of Laboratory Animals. Implements Health Research Extension Act of 1985 (PL 99-158, Animals in Research). Washington, D.C.: U.S. Department of Health and Human Services. 28. Available from: Office for Protection from Research Risks, Building 31, Room 4B09, NIH, Bethesda, MD 20892.
Pickar, D., M. Cohen, and A. Dubois. 1983. The relationship operative of plasma cortisol and beta endorphin immunoreactivity to surgical stress and postanalgesic requirement. Gen. Hosp. Psy. 5:93–98.
Piperno, E., D. J. Ellis, S. M. Getty, and T. M. Brody. 1968. Plasma and urine levels of phenylbutazone in the horse. J. Am. Vet. Med. Assoc. 153(2):195–198.
Porro, C. A., and G. Carli. 1988. Immobilization and restraint effects on pain reactions in animals. Pain 32:289–307.
Price, E. O. 1984. Behavioral aspects of animal domestication. Q. Rev. Biol. 59:1–32.
Price, E. O. 1985. Evolutionary and ontogenetic determinants of animal suffering and well-being. Pp. 15–26 in Animal Stress, G. P. Moberg, ed. Bethesda, Md.: American Physiological Society.
Price, D. D., and R. Dubner. 1977. Neurons that subserve the sensory-discriminative aspects of pain. Pain 3:307–338.
Price, D. D., J. W. Wu, R. Dubner, and R. H. Gracely. 1977. Peripheral suppression of first- pain and central summation of second pain evoked by noxious heat pulses . Pain 3:57–68.
Pry-Roberts, C., and C. C. Hug. 1984. Pp. 1–24 in Pharmacokinetics of Anesthesia. Boston, Mass.: Blackwell Scientific.
Reite, M., and T. Field, eds. 1985. The Psychobiology of Attachment and Separation. Orlando, Fla.: Academic Press. 508 pp.
Reutlinger, R. A., A. A. Karl, S. I. Vinal, and M. J. Nieser. 1980. Effects of ketamine HCI-xylazine HCI combination on cardiovascular and pulmonary values of the rhesus macaque (Macaca mulatta). Am. J. Vet. Res. 41:1453–1457.
Reynolds, A. K., and L. O. Randall. 1957. Morphine and Allied Drugs. Canada: University of Toronto Press.
Rigg, J. R. A., T. Y. Wong, P. Horsewood, and J. R. Hewson. 1981. Steady-state plasma fentanyl in the rabbit. Br. J. Anesth. 53:1337–1345.
Rowsell, H. C. 1981. The present status of euthanasia by nonanesthetic gases (Letter). Can. J. Vet. 22:8.
Rubright, W. C., and C. B. Thayer. 1970. The use of Innovar-Vet® as a surgical anesthetic for the guinea pig. Lab. Anim. Sci. 20(5):989–991.
Rubright, W. C., and C. B. Thayer. 1971. Innovar-Vet®: A surgical anesthetic for the guinea pig. Practicing Vet. 43(3):16–27.
Ruda, M. A., G. J. Bennett, and R. Dubner. 1986. Neurochemistry and neural circuitry in the dorsal horn. Pp. 219–268 in Progress in Brain Research, vol. 66, P. C. Emson, M. Rossor. and M. Tohyama, eds. New York: Elsevier.
Sadove, M. S., M. Shulman, H. Shigeru, and M. Feuold. 1971. Analgesic effects of ketamine administered in subdissociative doses. Anesth. Analg. 50:452–457.
Sanford, J., and S. R. Meacham. 1978. The use of ketamine for clinical restraint of the patus monkey. Proc. AVCPT. Fall.
Sanford, T. D., and E. D. Colby. 1980. Effect of xylazine and ketamine on blood pressure, heart rate and respiratory rate in rabbits. Lab. Anim. Sci. 30(3):519– 523.
Sawyer, D. C. 1988. Euthanasia agents and methods. Pp. 219–223 in Euthanasia of the Companion Animal, W. J. Kay, S. P. Cohen, C. E. Fudin, A. H. Kutscher, H. A. Nieburg, R. E. Grey, and M. M. Osman, eds. Philadelphia: The Charles Press.
Sawyer, D. C., and R. H. Rech. 1987. Analgesia and behavioral effects of butorphanol, and pentazocine in the cat. J. Am. Anim. Hosp. Assoc. 23:438–446.
Sawyer, D. C., D. L. Anderson, and J. B. Scott. 1982. Cardiovascular effects and clinical use of nalbuphine in the dog. Pp. 215–216 in Proc. 1st Intl. Cong. Vet. Anesth. (abstract). J. Assoc. Vet. Anesth. Gt. Br. Ireland. Cambridge, Eng.
Schoener, T. W. 1971. Theory of feeding strategies. Ann. Rev. Ecol. Syst. 2:369–404.
Sedgewick, C. J. 1980. Anesthesia for rabbits and rodents. Pp. 706–710 in Current Veterinary Therapy VII, R. W. Kir, ed. Philadelphia, Pa.: W. B. Saunders.
Selye, H. 1974. Stress Without Distress. Philadelphia, Pa.: J. B. Lippincott.
Short, C. E. (ed.). 1987. Principles and Practice of Veterinary Anesthesia. Baltimore, Md.: Williams & Wilkins. 669 pp.
Short, C. E., and A. Van Poznak. 1992. Animal Pain. New York: Churchill Livingstone. 587 pp.
Shucard, D. W., M. Andrew, and C. Beauford. 1975. A safe and fast-acting surgical anesthetic for use in the guinea pig. J. Appl. Physiol. 38(3):538–539.
Smith, J., and D. B. Morton. 1988. Legal protection for cephalopods? Institute of Medical Ethics' Working Party on the Ethics of Using Animals in Medical Research. London, UK.
Soma, L. R. (ed.). 1971. Textbook of Veterinary Anesthesia. Baltimore. Md.: Williams & Wilkins. 621 pp.
Soma, L. R. 1987. Assessment of animal pain in experimental animals. Lab. Anim. Sci. 37:71–74.
Soma, L. R., and A. Klide. 1987. Steady-state levels of anesthesia. J. Am. Vet. Med. Assoc. 191(10):1260–1265.
Soma, L. R., and D. R. Shields. 1964. Neuroleptanalgesia produced by fentanyl and droperidol. J. Am. Vet. Med. Assoc. 145:897.
Soma, L. R., W. J. Tierney, and N. Satoh. 1988a. Sevoflurane anesthesia in the monkey: The effects of multiples of MAC. Hiroshima J. Anesth. 24:3–14.
Soma L. R., E. Behrend, J. Rudy, and R. W. Sweeney. 1988b. Disposition and excretion of flunixin meglumine in horses. Am. J. Vet. Res. 49(11):1894–1898.
Spinelli, J. S., and H. Markowitz. 1987. Clinical recognition and anticipation of situations likely to induce suffering in animals. J. Am. Vet. Med. Assoc. 191(10):1216–1218.
Stanley W. C., and O. Elliot. 1962. Differential human handling as reinforcing events and as treatments influencing later social behavior in Basenji puppies. Psychol. Rep. 10:775–788.
Steffey, E. P. 1983. Concepts of general anesthesia and assessment of adequacy of anesthesia for animal surgery. Pp. 133–150 in Animal Pain: Perception and Alleviation, R. L. Kitchell and H. H. Erickson, eds. Bethesda, Md.: American Physiological Society.
Steffey, E. P., D. Howland, Jr., S. Giri, and E. I. Eger III. 1977. Enflurane, halothane, and isoflurane potency in horses. Am. J. Vet. Res. 38(7):1037–1039.
Stimpfel, T. M., and E. L. Gershey. 1991. Selecting anesthetic agents for human safety and animal recovery surgery. J. Fed. Am. Soc. Exptl. Biol. 5(7):2099–2104.
Stoelting, R. K. 1987. Pharmacology and Physiology in Anesthetic Practice. Philadelphia: J. B. Lippincott. 859 pp.
Stoelting, R. K., D. E. Longnecker, and E. I. Eger. 1970. Minimum alveolar concentrations in man on awakening from methoxyflurane, halothane, ether and fluroxane: MAC awake. Anesthesiology 33:5–9.
Strack, L. E., and H. M. Kaplan. 1968. Fentanyl and droperidol for surgical anesthesia of rabbits. J. Am. Vet. Med. Assoc. 153:822–825.
Szyfelbein, S., P. Osgood, and D. Carr. 1985. The assessment of pain and plasma beta endorphin immunoreactivity in burned children. Pain 22:173–182.
Tannenbaum, J. 1989. Veterinary Ethics. Baltimore, Md.: Williams & Wilkins. 358 pp.
Thurmon, J. C., A. Kumar, and R. P. Link. 1973. Evaluation of ketamine hydrochloride as an anesthetic in sheep. J. Am. Vet. Med. Assoc. 162(4):293–298.
Tomasovic, S. P., L. G. Coghlan, K. N. Gray, A. J. Mastromarino, and E. L. Travis. 1988. IACUC evaluation of experiments requiring death as an end point: A cancer center's recommendations. Lab Anim. 17(1):31–34.
Trim, C. M. 1983. Cardiopulmonary effects of butorphanol tartrate in dogs. Am. J. Vet. Res. 44(2):329–331.
Trim, C. M. 1987. Special anesthesia considerations in the ruminant. Pp. 285–300 in Princi-
ples and Practice of Veterinary Anesthesia, C. E. Short, ed. Baltimore, Md.: Williams & Wilkins.
Trim, C. M., and B. A. Gilroy. 1985. Cardiopulmonary effects of a xylazine and ketamine combination in pigs. Res. Vet. Sci. 38(1):30–34.
UFAW/WSPA (Universities Federation for Animal Welfare/World Society for the Protection of Animals). 1989. Euthanasia of Amphibians and Reptiles. Report of a Joint UFAW/ WSPA Working Party. Great Britain: Universities Federation for Animal Welfare. Potters Bar, Hertz, UK. and World Society for the Protection of Animals. London, UK. 35 pp.
Valverde, A., D. H. Dyson, W. N. McDonell, and P. J. Pascoe. 1989. Use of epidural morphine in the dog for pain relief. Vet. Comp. Orthoped. Traumatol. 2:55–58.
Van Citters, L. R., D. L. Franklin, and R. F. Rushmer. 1964. Left Ventricular dynamics in dogs during anesthesia with α-chloralose and sodium pentobarbital. Am. J. Cardiol. 13:349–354.
Van Sluyters, R. C., and M. D. Oberdorfer eds. 1991. Preparation and Maintenance of Higher Mammals During Neuroscience Experiments. Report of National Institutes of Health Workshop. NIH No. 91–3207.
Vanderlip, J. E., and B. A. Gilroy. 1981. Guidelines concerning the choice and use of anesthetics, analgesics and tranquilizers in laboratory animals. Office of Campus Veterinary Science. University of California, San Diego. 1981:1–27.
Vanderwolf, C. H., G. Buzsaki, D. P. Cain, R. K. Cooley, and B. Robertson. 1988. Neocortical and hippocampal electrical activity following decapitation in the rat. Brain Res. 451:340–344.
Vernberg J. F., and W. B. Vernberg. 1970. The Animal and the Environment. New York: Holt, Rinehart & Winston.
Vierck, C. J., Jr. 1976. Extrapolations from the pain research literature to problems of adequate veterinary care. J. Am. Vet. Med. Assoc. 168(6):510–513.
Vierck, C. J., Jr., B. Y. Cooper, and R. H. Cohen. 1983. Human and nonhuman primate reactions to painful electrocutaneous stimuli and to morphine. Pp. 117–132 in Animal Pain: Perception and Alleviation, R. L. Kitchell and H. H. Ericson, eds. Bethesda, Md.: American Physiological Society.
Visalberghi, E., and A. F. Vitale. 1990. Coated nuts as an enrichment device to elicit tool use in tufted capuchins (Cebus apella). Zoo Biol. 9(1):65–71.
Walden, N. B. 1978. Effective sedation of rabbits, guinea pigs, rats and mice with a mixture of fentanyl and droperidol. Austral. Vet. J. 54:538–540.
Ward, G. S., D. O. Johnsen, and C. R. Roberts. 1974. The use of CI 744 as an anesthetic for laboratory animals. Lab. Anim. Sci. 24(5):737–742.
Warren, R. G. 1983. Mosby's Fundamentals of Animal Health Technology: Small Animal Anesthesia. St. Louis, Mo.: C. V. Mosby. 367 pp.
Waser, P. M., and R. H. Wiley. 1979. Mechanisms and evolution of spacing in animals. Pp. 159–223 in Handbook of Behavioral Neurobiology: Vol. 3. Social Behavior and Communication, P. Marler and J. G. Vandenbergh, eds. New York: Plenum Press.
Wass, J. A., J. R. Keene, and H. M. Kaplan. 1974. Ketamine-methoxyflurane anesthesia for rabbits. Am. J. Vet. Res. 35(2):317–318.
Weinberg, J., and S. Levine. 1980. Psychobiology of coping in animals: The effects of predictability. Pp. 39–59 in Coping and Health, S. Levine and H. Ursin, eds. New York: Plenum Press.
Weiskopf R. B., and M. S. Bogetz. 1984. Minimum alveolar concentrations (MAC) of halothane and nitrous oxide in swine. Anesth. Analg. 63(5):529–532.
Wemelsfelder, F. 1990. Boredom and laboratory animal welfare. Pp. 243–272 in The Experimental Animal in Biomedical Research, B. E. Rollin, ed. Boca Raton, Fla.: CRC Press.
White, P. F., R. R. Johnston, and E. I. Eger. 1974. Determination of anesthetic requirement in rats. Anesthesiology 40(1):52–57.
White, P. F., R. R. Johnston, and C. R. Pudwill. 1975. Interaction of ketamine and halothane in rats. Anesthesiology 42(2):179–186.
White, S. D. 1990. Naltrexone for the treatment of acral lick dermatitis in dogs. J. Am. Vet. Med. Assoc. 196(7):1073–1076.
Wigglesworth, V. B. 1980. Do insects feel pain? Antenna 4:8–9.
Willis, W. D. 1985. The Pain System—The Neural Basis of Nociceptive Transmission in the Mammalian Nervous System. New York: S. Karger. 346 pp.
Wilson, P., and A. M. Wheatley. 1981. Ketamine hydrochloride in the laboratory rat. Lab. Anim. 15(4):349.
Winters, W. D., T. Ferrar-Allado, C. Guzman-Flores, and M. Alcarez. 1972. The cataleptic state induced by ketamine: A review of the neuropharmacology of anesthesia. Neuropharmacology 1:303–315.
Wixson, S. K., W. J. White, H. C. Hughes, Jr., C. M. Lang, and W. K. Marshall. 1987a. A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. Lab. Anim. Sci. 37(6):726–730.
Wixson, S. K., W. J. White, H. C. Hughes, Jr., W. K. Marshall, and C. M. Lang. 1987b. The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats. Lab. Anim. Sci. 37(6):731–735.
Wixson, S. K., W. J. White, H. C. Hughes, Jr., C. M. Lang, and W. K. Marshall. 1987c. The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on arterial blood pH, blood gases, mean arterial blood pressure and heart rate in adult male rats. Lab. Anim. Sci. 37(6):736–742.
Wolff, B. B. 1978. Behavioral measurement of human pain. Pp. 129–168 in The Psychology of Pain, R. A. Sternbach, ed. New York: Raven Press.
Wolfle, T. L. 1985. Laboratory animal technicians: Their role in stress reduction and human companion animal bonding. Vet. Clin. N. Am.: Small Anim. Pract. 15(2):449–454.
Wolfle, T. L. 1987. Control of stress using non-drug approaches. J. Am. Vet. Med. Assoc. 191(10):1219–1221.
Wolfle, T. L., and J.C. Liebeskind. 1983. Stimulation-produced analgesia. Pp. 107–115 in Animal Pain: Perception and Alleviation. Bethesda, Md.: American Physiological Society.
Woolfson, M. W., J. A. Foran, H. M. Freedman, P. A. Moore, L. B. Shulman, and P. A. Schnitman. 1980. Immobilization of baboons (Papio anubis) using ketamine and diazepam. Lab. Anim. Sci. 30(5):902–904.
Wright, M. 1982. Pharmacologic effects of ketamine and its use in veterinary medicine. J. Am. Vet. Med. Assoc. 180:1462–1470.
Wright, E. M., K. L. Marcella, and J. F. Woodson. 1985. Animal pain: Evaluation and control. Lab Anim. 14(4):20–36.
Yaksh, T. L., and T. A. Rudy. 1978. Narcotic analgesia: CNS sites and mechanisms of action as revealed by intracerebral injection techniques. Pain 4:299–359.
Yates, W. D. 1973. Clinical uses of xylazine: A new drug for old problems. Vet./Small Anim. Clin. 63:483–486.
Zimmermann, M. 1984. Neurobiological concepts of pain, its assessment and therapy. Pp. 15–35 in Pain Measurement in Man: Neurophysiological Correlates of Pain, B. Bromm, ed. Amsterdam: Elsevier Press.