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DEC 05 1S79 LIBRARY
f re ' ;â¢[â¢ FIRST SYMPOSIUM aÂ« ^* * emical - Biological Chemical-Biological Coordination Cente NATIONAL RESEARCH COUNCIL publication 206 NATIONAL ACADEMY OF SCIENCES
CHEMICAL-BIOLOGICAL COORDINATION CENTER National Research Council W. R. KIRNER, Director âNational Research Council ADVISORY COMMITTEE* âCornell University Medical College McKEEN CATTELL, Chairman (Physiology-Pharmacology) ROGER ADAMS (Organic Chemistry) HARRY EAGLE (Chemotherapy) R. L. BEARD (Entomology) WILLIAM H. STEIN (Biochemistry) JOHN VV. MITCHELL (Plant Sciences) A. McGEHEE HARVEY (Medicine) REMINGTON KELLOGG (Mammalogy) R. A. KELSER (Veterinary Medicine) W. A. NOYES, JR. (Physical Chemistry) H. P. TREFFERS (Microbiology) C. CHESTER STOCK (Malignancy) ABEL WOLMAN (Sanitary Engineering) *The Chairmen of the various subcommittees of the Center constitute the Advis- ory Committee. For the names of the members of the Center's subcommittees and panels see the National Research Council booklet Organization and Members. âUniversity of Illinois âNational Institutes of Health âConnecticut Agricultural Experiment Station âRockefeller Institute for Medical Research âU. S. Department of Agriculture âJohns Hopkins University Hospital âSmithsonian Institution âUniversity of Pennsylvania âUniversity of Rochester âYale University School of Medicine âSloan-Kettering Institute for Cancer Research âJohns Hopkins University Price
FIRST SYMPOSIUM ON CHEMICAL-BIOLOGICAL CORRELATION
RM260.N365 1950c.l First symposium on chemical-biological correlation, ...
FIRST SYMPOSIUM ON CHEMICAL-BIOLOGICAL CORRELATION May 26-27, 1950 Sponsored by The Chemical-Biological Coordination Center of the National Research Council National Academy of Sciences-National Research Council Washington, D. C. 1951
H7W .C..2- The Chemical-Biological Coordination Center is affiliated directly with the Executive Board of the National Research Council of which Mr. William W. Rubey is Chairman. It was established on July 1, 1946, and succeeded the O.S.R.D. Insect Control Committee. Its objectives are: (1) To assemble and organize information which describes (a) the effect of chemi- cals on biological systems (plants and animals, their organs, tissues, cells and cell constituents); (b) the metabolism of test chemicals within biological systems; (c) the mechanism of drug action or which provides information leading to an understanding of such action. (Z) To sponsor the preliminary testing ("screening") of compounds, solicited by the Center, on a variety of plants and animals (including microorganisms) to determine the biological effects of the compounds and to make the resulting data available for use. (3) To prepare reviews of the literature on: (a) The effect of chemical structure upon various biological actions; (b) Test methods used in determining such actions. (4) To sponsor symposia concerned with the correlation of chemical structure with biological activity. The data in the files of the Center are available to representatives of the sponsoring agencies, the screening agencies and to authorized scientists generally upon request. The sponsoring agencies are the Atomic Energy Commission, the Department of the Army, the Department of the Navy, the U.S. Public Health Service and the American Cancer Society.
FOREWORD This is the first of a proposed series of volumes containing informa- tion presented at biannual symposia sponsored by the Chemical-Biological Coordination Center of the National Research Council. The purpose of these symposia is to bring together scientists trained in chemistry and biology for discussion of problems concerned with the effect of the structure of chemicals on their biological activity and the mechanism of such actions. With this purpose in mind the title assigned to the first symposium was "Chemical-Biological Correlation". The Chemical-Biological Coordination Center expresses its sincere appreciation to the chemists and biologists whose names appeared on the program and who prepared and presented the papers published in this volume, to the scientists who discussed the papers, and to the approximately three hundred and fifty symposium attendants. The Center is also grateful to Dr. Ralph E. Cleland, Chairman of the National Research Council Division of Biology and Agriculture, to Dr. M. C. Winternitz, Chairman of the NRC Division of Medical Sciences, to Dr. F. C. Bishopp, Assistant Chief of the Bureau of Entomology and Plant Quarantine, U. S. Department of Agriculture, and to Dr. Ralph L*. Shriner of the State University of Iowa, who represented the NRC Division of Chemistry and Chemical Technology, for presiding at the several sessions of this symposium. The success of the first symposium is, in large measure, due to the careful planning of the Program Committee, which was composed of the following members: Charles P. Huttrer, Chairman, R. L. Beard, McKeen Cattell and C. Chester Stock. Acknowledgment is also made of the important contributions rendered by Mrs. Helen M. Moore in typing the manuscript for reproduction in its present form and by the staff of the Center in proof- reading the manuscript.