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Suggested Citation:"Appendix A: Statement of Task." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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Appendix A

Statement of Task

An ad hoc committee will plan and conduct a public workshop in September 2013 in Washington, DC. This one day workshop will explore the current state of antibiotic development, examine the technology available to facilitate development, the technical challenges present, identify approaches to antibiotic discovery, and discuss the incentives and disincentives industry faces in antibiotic development.

The workshop will be held in the context of the need to enable antibiotic development in light of the decreasing availability of new antimicrobial agents.

The committee will develop the workshop agenda, select and invite speakers and other participants, and moderate the discussions. The focus of the workshop will be on three main goals:

  1. Identify and examine the state of antibiotic research and development;
  2. Discuss the technical difficulties in antibiotic discovery; and
  3. Highlight recent successful approaches for the development of novel antimicrobials.
Suggested Citation:"Appendix A: Statement of Task." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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Suggested Citation:"Appendix A: Statement of Task." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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Page 25
Suggested Citation:"Appendix A: Statement of Task." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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Page 26
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Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery.

Antibiotic resistance is a serious and growing problem in modern medicine and it is emerging as a pre-eminent public health threat. Each year in the United States alone, at least two million acquire serious infections with bacteria that are resistant to one or more antibiotics, and at least 23,000 people die annually as a direct result of these antibiotic-resistant infections. In addition to the toll on human life, antibiotic-resistant infections add considerable and avoidable costs to the already overburdened U.S. health care system. This report explores the challenges in overcoming antibiotic resistance, screening for new antibiotics, and delivering them to the sites of infection in the body. The report also discusses a path forward to develop the next generation of potent antimicrobial compounds capable of once again tilting the battle against microbial pathogens in favor of humans. Technological Challenges in Antibiotic Discovery and Development gives a broad view of the landscape of antibiotic development and the technological challenges and barriers to be overcome.

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