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Suggested Citation:"Appendix B: Agenda." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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Appendix B

Agenda

Technological Challenges in Antibiotic Discovery and Development

A Workshop by the Chemical Sciences Roundtable

September 23, 2013—Washington, DC

8:00 – 8:15   Introduction to Workshop and Topic

Session 1: Overview
Chair: Carole Bewley, CSR Member

8:15 – 9:15   Resistance is Futile: A View from the AR Battlefield
Rosemary Aurigemma, Section Chief, Drug Development, NIAID, NIH
 
9:15 – 9:45   Break

Session 2: Challenges in Overcoming Antibiotic Resistance
Chair: Ken Moloy, CSR Member

9:45 – 10:30   Selecting Antibacterial Targets to avoid Resistance Selection
Lynn Silver, Consultant, formerly with Merck
 
10:30 – 11:15   The Complex Resistance Machineries for β-Lactam Antibiotics in Gram-Negative and Gram-Positive Bacteria
Shahriar Mobashery, Department of Chemistry and Biochemistry, University of Notre Dame
 
11:15 – 11:45   Discussion with Speakers
 
11:45 – 12:45   Lunch

Session 3: Challenges in Screening
Chair: John Kozarich, CSR Member

12:45 – 1:30   Challenges in Discovering New Antibiotics Through Screening
Karen Shaw, Sr. Vice President, Biology, Trius Therapeutics
 
Suggested Citation:"Appendix B: Agenda." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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1:30 – 2:15   New Ways of Looking at Old Antibiotics and Their Targets
Chaitan Khosla, Department of Chemical Engineering, Stanford University
 
2:15 – 2:45   Discussion with Speakers
 
2:45 – 3:15   Break

Session 4: Challenges in Drug Delivery
Chair: Luis Martinez, CSR Member

3:15 – 4:00   Novel Approaches to Antimicrobial Therapeutic Design: A Story of Cocktails and In Vivo Nanomachines
J. Ruben Morones-Ramírez, Enbiotix and Universidad Autónoma de Nuevo León
 
4:00 – 4:45   Overcoming Antibiotic Challenges in Biofilm-Associated Infection
Mark Smeltzer, University of Arkansas Medical Center
 
4:45 – 5:15   Discussion with Speakers

Closing Discussion: The Path Forward
Chair: John Kozarich, CSR Member

5:15 – 6:00   Overall panel discussion with all speakers
 
6:00   Workshop Adjourns
Suggested Citation:"Appendix B: Agenda." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
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Page 27
Suggested Citation:"Appendix B: Agenda." National Research Council. 2014. Technological Challenges in Antibiotic Discovery and Development: A Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18616.
×
Page 28
Next: Appendix C: Biographical Information »
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Technological Challenges in Antibiotic Discovery and Development is the summary of a workshop convened by the Chemical Sciences Roundtable in September 2013 to explore the current state of antibiotic discovery and examine the technology available to facilitate development. Through formal presentations and panel discussions, participants from academia, industry, federal research agencies discussed the technical challenges present and the incentives and disincentives industry faces in antibiotic development, and identified novel approaches to antibiotic discovery.

Antibiotic resistance is a serious and growing problem in modern medicine and it is emerging as a pre-eminent public health threat. Each year in the United States alone, at least two million acquire serious infections with bacteria that are resistant to one or more antibiotics, and at least 23,000 people die annually as a direct result of these antibiotic-resistant infections. In addition to the toll on human life, antibiotic-resistant infections add considerable and avoidable costs to the already overburdened U.S. health care system. This report explores the challenges in overcoming antibiotic resistance, screening for new antibiotics, and delivering them to the sites of infection in the body. The report also discusses a path forward to develop the next generation of potent antimicrobial compounds capable of once again tilting the battle against microbial pathogens in favor of humans. Technological Challenges in Antibiotic Discovery and Development gives a broad view of the landscape of antibiotic development and the technological challenges and barriers to be overcome.

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