Technological Challenges in Antibiotic Discovery and Development
A Workshop by the Chemical Sciences Roundtable
September 23, 2013—Washington, DC
8:00 – 8:15 | Introduction to Workshop and Topic |
Session 1: Overview
Chair: Carole Bewley, CSR Member
8:15 – 9:15 | Resistance is Futile: A View from the AR Battlefield Rosemary Aurigemma, Section Chief, Drug Development, NIAID, NIH |
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9:15 – 9:45 | Break |
Session 2: Challenges in Overcoming Antibiotic Resistance
Chair: Ken Moloy, CSR Member
9:45 – 10:30 | Selecting Antibacterial Targets to avoid Resistance Selection Lynn Silver, Consultant, formerly with Merck |
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10:30 – 11:15 | The Complex Resistance Machineries for β-Lactam Antibiotics in Gram-Negative and Gram-Positive Bacteria Shahriar Mobashery, Department of Chemistry and Biochemistry, University of Notre Dame |
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11:15 – 11:45 | Discussion with Speakers | |
11:45 – 12:45 | Lunch |
Session 3: Challenges in Screening
Chair: John Kozarich, CSR Member
12:45 – 1:30 | Challenges in Discovering New Antibiotics Through Screening Karen Shaw, Sr. Vice President, Biology, Trius Therapeutics |
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1:30 – 2:15 | New Ways of Looking at Old Antibiotics and Their Targets Chaitan Khosla, Department of Chemical Engineering, Stanford University |
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2:15 – 2:45 | Discussion with Speakers | |
2:45 – 3:15 | Break |
Session 4: Challenges in Drug Delivery
Chair: Luis Martinez, CSR Member
3:15 – 4:00 | Novel Approaches to Antimicrobial Therapeutic Design: A Story of Cocktails and In Vivo Nanomachines J. Ruben Morones-Ramírez, Enbiotix and Universidad Autónoma de Nuevo León |
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4:00 – 4:45 | Overcoming Antibiotic Challenges in Biofilm-Associated Infection Mark Smeltzer, University of Arkansas Medical Center |
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4:45 – 5:15 | Discussion with Speakers |
Closing Discussion: The Path Forward
Chair: John Kozarich, CSR Member
5:15 – 6:00 | Overall panel discussion with all speakers | |
6:00 | Workshop Adjourns |