The Richard & Hinda
Rosenthal Symposium
2014
Antimicrobial Resistance:
A Problem Without Borders
INSTITUTE OF MEDICINE
OF THE NATIONAL ACADEMIES
THE NATIONAL ACADEMIES PRESS
Washington, D.C.
www.nap.edu
THE NATIONAL ACADEMIES PRESS • 500 Fifth Street, NW • Washington, DC 20001
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.
Support for this project was provided by the Rosenthal Family Foundation.
International Standard Book Number-13: 978-0-309-31286-8
International Standard Book Number-10: 0-309-31286-8
Additional copies of this report are available from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.
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Copyright 2014 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America
The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of Medicine is a relief carving from ancient Greece, now held by the Staatliche Museen in Berlin.
Suggested citation: IOM (Institute of Medicine). 2014. The Richard & Hinda Rosenthal Symposium 2014: Antimicrobial Resistance: A Problem Without Borders. Washington, DC: The National Academies Press.
“Knowing is not enough; we must apply.
Willing is not enough; we must do.”
—Goethe
INSTITUTE OF MEDICINE
OF THE NATIONAL ACADEMIES
Advising the Nation. Improving Health.
THE NATIONAL ACADEMIES
Advisers to the Nation on Science, Engineering, and Medicine
The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences.
The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. C. D. Mote, Jr., is president of the National Academy of Engineering.
The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Victor J. Dzau is president of the Institute of Medicine.
The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. C. D. Mote, Jr., are chair and vice chair, respectively, of the National Research Council.
Foreword
The Institute of Medicine (IOM) launched an innovative outreach program in 1988. Through the generosity of the Rosenthal Family Foundation (formerly the Richard and Hinda Rosenthal Foundation), a discussion series was created to bring greater attention to some of the significant health policy issues facing our nation today. Each year a major health topic is addressed through remarks and conversation between experts in the field. The IOM later publishes the proceedings from this event for the benefit of a wider audience.
The Rosenthal events have attracted an enthusiastic following among health policy researchers and decision makers in Washington, DC, and across the country, and produce a dynamic and fruitful dialogue. In this volume, we are proud to present remarks by and an engaging discussion with Dr. Rima Khabbaz, Dr. Stuart Levy, Dr. Margaret (Peg) Riley, and Dr. Brad Spellberg on “Antimicrobial Resistance: A Problem Without Borders.”
I would like to thank Daniel Bethea, Katharine Bothner, Leigh Carroll, Marton Cavani, Eileen Choffnes, Bradley Eckert, Greta Gorman, India Hook-Barnard, Patrick Kelley, Abbey Meltzer, Meghan Mott, Patsy Powell, Lauren Shern, and Liz Tyson for skillfully handling the many details associated with the symposium program and the publication.
In their lifetimes, Richard and Hinda Rosenthal accomplished a great deal. The annual Rosenthal Symposium at the IOM is among their enduring legacies, and we are privileged to be the steward of this important ongoing series.
Victor J. Dzau, M.D.
President
Institute of Medicine
Contents
PANELIST REMARKS AND DISCUSSION
Rima F. Khabbaz
Deputy Director for Infectious Diseases
Director, Office of Infectious Diseases
Centers for Disease Control and Prevention
Stuart B. Levy
Distinguished Professor of Molecular Biology and Microbiology and of Medicine
Director, Center for Adaptation Genetics and Drug Resistance
Tufts University School of Medicine
Margaret A. Riley
Professor, Department of Biology
University of Massachusetts Amherst
Brad Spellberg
Associate Medical Director for Inpatient Services
Harbor-UCLA Medical Center