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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

The Role of Clinical Studies
for Pets with Naturally
Occurring Tumors in

TRANSLATIONAL
CANCER
RESEARCH

Workshop Summary

Sharyl J. Nass and Heather Gorby, Rapporteurs

National Cancer Policy Forum

Board on Health Care Services

Institute of Medicine

images

THE NATIONAL ACADEMIES PRESS
Washington, DC
www.nap.edu

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

THE NATIONAL ACADEMIES PRESS    500 Fifth Street, NW    Washington, DC 20001

This project was supported by the Animal Cancer Foundation; the College of Veterinary Medicine at North Carolina State University; the Cornell University School of Veterinary Medicine; Flint Animal Cancer Center, Colorado State University; the Morris Animal Foundation; the Ohio State University School of Veterinary Medicine; Purdue University College of Veterinary Medicine and the Center for Cancer Research; the Skippy Frank Translational Medicine and Life Sciences Fund; the University of California, Davis, School of Veterinary Medicine; the University of Colorado Cancer Center; the University of Florida College of Veterinary Medicine; the University of Georgia College of Veterinary Medicine; the University of Illinois College of Veterinary Medicine; the University of Minnesota College of Veterinary Medicine; the University of Missouri College of Veterinary Medicine and the Ellis Fischel Cancer Center; the University of Pennsylvania; the University of Wisconsin–Madison Carbone Cancer Center, Institute for Clinical and Translational Research, and the School of Veterinary Medicine; and the Washington State University College of Veterinary Medicine. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

International Standard Book Number-13: 978-0-309-37990-8
International Standard Book Number-10: 0-309-37990-3
DOI: 10.17226/21830

Additional copies of this workshop summary are available for sale from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

Copyright 2015 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America

Cover image contributed by Joe Mendoza/Colorado State University Photography. Angela’s surgery for her bone cancer was first developed by Dr. Withrow in pet dogs with the same disease. This treatment advancement continues to help dogs and people with bone cancer.

Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2015. The role of clinical studies for pets with naturally occurring tumors in translational cancer research: Workshop summary. Washington, DC: The National Academies Press.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

images

The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Ralph J. Cicerone is president.

The National Academy of Engineering was established in 1964 under the charter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineering. Dr. C. D. Mote, Jr., is president.

The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president.

The three Academies work together as the National Academies of Sciences, Engineering, and Medicine to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine.

Learn more about the National Academies of Sciences, Engineering, and Medicine at www.national-academies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

WORKSHOP PLANNING COMMITTEE1

MICHAEL B. KASTAN (Chair), Executive Director, Duke Cancer Institute

MARK DEWHIRST, Co-director, Radiation Oncology/Imaging Program, Duke University School of Medicine

CHAND KHANNA, Senior Investigator, Pediatric Oncology Branch, National Cancer Institute

JOHN K. LEIGHTON, Acting Director, Division of Hematology Oncology Toxicology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration

PATRICIA N. OLSON, Independent Advisor on Animal Health and Welfare

ELAINE A. OSTRANDER, Chief and Distinguished Investigator, National Human Genome Research Institute

BEVERLY A. TEICHER, Chief, Molecular Pharmacology Branch Developmental Therapeutics Program, National Cancer Institute

DANIEL B. TUMAS, Senior Director, Biology, Gilead Sciences, Inc.

Project Staff

SHARYL J. NASS, Director, National Cancer Policy Forum

PATRICK ROSS, Research Assistant

HANNAH DURING, Senior Program Assistant

________________

1 Institute of Medicine planning committees are solely responsible for organizing the workshop, identifying topics, and choosing speakers. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

This page intentionally left blank.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

NATIONAL CANCER POLICY FORUM1

MICHAEL CALIGIURI (Chair), Chief Executive Officer, James Cancer Hospital and Solove Research Institute; Director, Ohio State University Comprehensive Cancer Center

PATRICIA A. GANZ (Vice Chair), Distinguished University Professor, University of California, Los Angeles (UCLA), Fielding School of Public Health, David Geffen School of Medicine at UCLA, Jonsson Comprehensive Cancer Center

AMY P. ABERNETHY, Chief Medical Officer and Senior Vice President for Oncology, Flatiron Health; Professor, Division of Medical Oncology, Duke University School of Medicine; Director, Center for Learning Health Care, Duke Clinical Research Institute

LUCILE ADAMS-CAMPBELL, Professor of Oncology, Associate Director for Minority Health and Health Disparities Research, Georgetown University Lombardi Cancer Center

KENNETH ANDERSON, Kraft Family Professor of Medicine, American Cancer Society Clinical Research Director, Jerome Lipper Multiple Myeloma Center, Harvard Medical School, Dana-Farber Cancer Institute

LOYCE PACE BASS, Health Policy Director, LIVESTRONG Foundation

MONICA BERTAGNOLLI, Professor of Surgery, Harvard Medical School

OTIS BRAWLEY, Chief Medical Officer and Executive Vice President, American Cancer Society

CARLTON BROWN, Director of Professional Services, Oregon Nurses Association; Past President, Oncology Nursing Society

SERGIO CANTOREGGI, Chief Scientific Officer and Global Head of Research and Development, Helsinn Group

ROBERT W. CARLSON, Chief Executive Officer, National Comprehensive Cancer Network

GREGORY CURT, U.S. Medical Science Lead, AstraZeneca

________________

1 Institute of Medicine planning committees are solely responsible for organizing the workshop, identifying topics, and choosing speakers. The responsibility for the published workshop summary rests with the workshop rapporteurs and the institution.

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

WILLIAM S. DALTON, Chief Executive Officer, M2Gen Personalized Medicine Institute, Moffitt Cancer Center; Chair, American Association for Cancer Research Science Policy and Government Affairs Committee

GWEN DARIEN, Executive Vice President, Programs and Services, Cancer Policy Institute, Cancer Support Community

WENDY DEMARK-WAHNEFRIED, Associate Director for Cancer Prevention and Control, University of Alabama at Birmingham Comprehensive Cancer Center

JAMES DOROSHOW, Deputy Director, National Cancer Institute

CAROL A. HAHN, Associate Professor of Radiation Oncology, Duke University Medical Center; Medical Director of Radiation Oncology, Duke Raleigh Hospital; Clinical Affairs and Quality Council Chair, American Society for Radiation Oncology

LORI HOFFMAN HŌGG, Veterans Health Administration National Oncology Clinical Advisor, Office of Nursing Services; Cancer Program Director, Albany Stratton Veterans Affairs Medical Center

SAMIR N. KHLEIF, Director, Georgia Health Sciences University Cancer Center, Georgia Regents University Cancer Center

RONALD M. KLINE, Medical Officer, Patient Care Models Group, Center for Medicare & Medicaid Innovation

LEE M. KRUG, Disease Area Head, Immuno-Oncology, Bristol-Myers Squibb

RICHARD A. LARSON, Hematology/Oncology Director, University of Chicago

MICHELLE M. LE BEAU, Arthur and Marian Edelstein Professor of Medicine, Director, Comprehensive Cancer Center, University of Chicago

GRETA MASSETTI, Associate Director for Science, Division of Cancer Prevention and Control, Centers for Disease Control and Prevention

DANIEL R. MASYS, Affiliate Professor, Biomedical Informatics, University of Washington

MARTIN J. MURPHY, Chief Executive Officer, CEO Roundtable on Cancer

RICHARD PAZDUR, Director, Office of Oncology and Hematology Products, U.S. Food and Drug Administration

STEVEN PIANTADOSI, Phase One Foundation Endowed Chair and Director, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

JENNIFER A. PIETENPOL, Director, Vanderbilt-Ingraham Cancer Center, Benjamin F. Byrd, Jr., Professor of Oncology, Professor of Biochemistry, Vanderbilt University

AUGUST SALVADO, Senior Vice President, U.S. Oncology Clinical Development & Medical Affairs, Novartis Oncology

ANDREW SCHIERMEIER, Senior Vice President, Head of Global Oncology, Merck Serono

RICHARD SCHILSKY, Chief Medical Officer, American Society of Clinical Oncology

DEBORAH SCHRAG, Chief, Division of Population Sciences, Professor of Medicine, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School

YA-CHEN TINA SHIH, Professor of Health Economics, Chief, Section of Cancer Economics and Policy, Department of Health Services Research, University of Texas MD Anderson Cancer Center

ELLEN V. SIGAL, Chair and Founder, Friends of Cancer Research

RALPH WEICHSELBAUM, Daniel K. Ludwig Professor and Chair, Department of Radiation Oncology, Director, Ludwig Center for Metastasis Research, The University of Chicago Medical Center

GEORGE J. WEINER, Director, Holden Comprehensive Cancer Center, University of Iowa; President, Association of American Cancer Institutes

WENDY WOODWARD, Associate Professor and the Section Chief of Clinical Breast Radiation, Department of Radiation Oncology, University of Texas MD Anderson Cancer Center

National Cancer Policy Forum Staff

SHARYL J. NASS, Forum Director and Director, Board on Health Care Services

ERIN BALOGH, Program Officer

PATRICK ROSS, Research Assistant

HANNAH DURING, Senior Program Assistant (until August 2015)

CYNDI TRANG, Senior Program Assistant (from August 2015)

PATRICK BURKE, Financial Associate

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

Reviewers

This workshop summary has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published workshop summary as sound as possible and to ensure that the workshop summary meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this workshop summary:

JEFF ALLEN, Friends of Cancer Research

PETER CHOYKE, National Cancer Institute

SHIVAANI KUMMAR, Stanford University Medical Center

PERRY NISEN, Sanford Burnham Prebys Medical Discovery Institute

SUZANNE PARSEL, Kansas State University

Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the workshop summary before its release. The review of this report was overseen by ELI Y. ADASHI, Warren Alpert Medical School at Brown University. He was responsible for making certain that an independent examination

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

of this report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this report rests entirely with the rapporteurs and the institution.

Page xiii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

Acknowledgments

We thank the coalition of sponsors who supported this project. The sponsors included the Animal Cancer Foundation; the College of Veterinary Medicine at North Carolina State University; the Cornell University School of Veterinary Medicine; Flint Animal Cancer Center, Colorado State University; the Morris Animal Foundation; the Ohio State University School of Veterinary Medicine; Purdue University College of Veterinary Medicine and the Center for Cancer Research; the Skippy Frank Translational Medicine and Life Sciences Fund; the University of California, Davis, School of Veterinary Medicine; the University of Colorado Cancer Center; the University of Florida College of Veterinary Medicine; the University of Georgia College of Veterinary Medicine; the University of Illinois College of Veterinary Medicine; the University of Minnesota College of Veterinary Medicine; the University of Missouri College of Veterinary Medicine and the Ellis Fischel Cancer Center; the University of Pennsylvania; the University of Wisconsin–Madison Carbone Cancer Center, Institute for Clinical and Translational Research, and the School of Veterinary Medicine; and the Washington State University College of Veterinary Medicine.

Support from the many annual sponsors of the Institute of Medicine’s National Cancer Policy Forum is also crucial to the work of the Forum. Federal sponsors include the Centers for Disease Control and Prevention and the National Cancer Institute/National Institutes of Health. Nonfederal sponsors include the American Association for Cancer Research, American

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

Cancer Society, American Society for Radiation Oncology, American Society of Clinical Oncology, American Society of Hematology, Association of American Cancer Institutes, AstraZeneca, Bristol-Myers Squibb, Cancer Support Community, CEO Roundtable on Cancer, EMD Serono, Helsinn Healthcare SA, LIVESTRONG Foundation, National Comprehensive Cancer Network, Novartis Oncology, and the Oncology Nursing Society.

The Forum wishes to express its gratitude to the expert speakers whose presentations helped define the current challenges and opportunities for integrating comparative oncology trials within the cancer research continuum. The Forum also wishes to thank the members of the planning committee for their work in developing an excellent workshop agenda.

Page xvii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×
Page xviii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
×

Acronyms and Abbreviations

ATP adenosine triphosphate
BTK Bruton tyrosine kinase
CCOGC Canine Comparative Oncology and Genomics Consortium
CML chronic myeloid leukemia
COTC Comparative Oncology Trials Consortium
CT computed tomography
CTVT canine transmissible venereal tumor
DCE-MRI dynamic contrast-enhanced magnetic resonance imaging
DSMB data safety and monitoring board
FDA U.S. Food and Drug Administration
FDG flourodeoxyglucose
FLT fluorothymidine
F-TFB F-tetrafluoroborate
GEMM Genomic-Enabled Medicine for Melanoma (trial)
HCQ hydroxychloroquine
HIPAA Health Insurance Portability and Accountability Act
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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IACUC institutional animal care and use committee
IND investigational new drug (application)
IOM Institute of Medicine
IRB institutional review board
MRI magnetic resonance imaging
MTD maximum tolerated dose
NCI National Cancer Institute
NHL non-Hodgkin’s lymphoma
PBMC peripheral blood mononuclear cell
PD pharmacodynamic
PDX patient-derived xenograft
PET positron emission tomography
PI principal investigator
PK pharmacokinetic
TBR target-to-background ratio
TCC transitional cell carcinoma
TGEN Translational Genomics Research Institute
TNF tumor necrosis factor
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2015. The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/21830.
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Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models. Thus, researchers are seeking new approaches to augment preclinical knowledge before undertaking clinical trials for human patients.

Recently, there has been renewed interest in comparative oncology - the study of naturally developing cancers in animals as models for human disease - as one way to improve cancer drug development and reduce attrition of investigational agents. Tumors that spontaneously develop in pet dogs and other companion animals as a result of normal aging share many characteristics with human cancers, such as histological appearance, tumor genetics, biological behavior, molecular targets, and therapeutic response.

In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop.

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