Appendix B

Example Report Outlines for Future SMAC and SWEG Documents

OUTLINE FOR NEW CHEMICALS

1. Physical and Chemical Properties
2. Occurrence, Source, and Use on Spacecraft
3. Toxicokinetics
4. Toxicodynamics and Mechanism of Action
5. Toxicity Summary
   1. Literature Search Strategy (summary of databases, dates, search terms, etc.)
   2. Acute Toxicity
      1. Human
      2. Animal
   3. Short-Term Toxicity
      1. Human
      2. Animal
   4. Subchronic Toxicity
      1. Human
      2. Animal
   5. Chronic Toxicity
      1. Human
      2. Animal
   6. Interaction with Other Chemicals
   7. Spaceflight Effects
6. Rationale for Acceptable Concentrations
   1. Description of How Each SMAC/SWEG Was Derived (to include detailed justification of the selection of health end points, key studies, point of departure, and uncertainty factors)
   2. Exposure Standards Set by Other Organizations
7. Research Recommendations

OUTLINE FOR UPDATING CHEMICAL GUIDELINES

1. Occurrence, Source, and Use on Spacecraft
2. Summary of Original Approach to Setting SMACs or SWEGs
3. New Data
   1. Literature Search Strategy (databases, dates, search terms, etc.)
   2. Toxicokinetics
   3. Toxicodynamics and Mechanism of Action
   4. Acute Toxicity
   5. Short-Term Toxicity
   6. Subchronic Toxicity
   7. Chronic Toxicity
   8. Interaction with Other Chemicals
   9. Spaceflight Effects
4. Rationale for Revision to the Original SMACs or SWEGs
   1. Description of Revisions to Each SMAC/SWEG (to include detailed justification of the selection of health end points, key studies, point of departure, and uncertainty factors)
   2. Exposure Standards Set by Other Organizations
5. Research Recommendations

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