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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Developing Multimodal
Therapies for Brain Disorders

Proceedings of a Workshop

Lisa Bain, Noam I. Keren, and Clare Stroud, Rapporteurs

Forum on Neuroscience and
Nervous System Disorders

Board on Health Sciences Policy

Health and Medicine Division

images

THE NATIONAL ACADEMIES PRESS
Washington, DC
www.nap.edu

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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THE NATIONAL ACADEMIES PRESS • 500 Fifth Street, NW • Washington, DC 20001

This project was supported by contracts between the National Academy of Sciences and the Alzheimer’s Association; Brain Canada Foundation; Cohen Veterans Bioscience; the Department of Health and Human Services’ Food and Drug Administration (5R13FD005362-02) and National Institutes of Health (NIH) (HHSN26300089 [Under Master Base # DHHS-10002880]) through the National Center for Complementary and Integrative Health, National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; Department of Veterans Affairs (VA240-14-C-0057); Eli Lilly and Company; Foundation for the National Institutes of Health; Gatsby Charitable Foundation; Janssen Research & Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson’s Research; National Multiple Sclerosis Society; National Science Foundation (BCS-1064270); One Mind; Pfizer Inc.; Pharmaceutical Product Development, LLC; Sanofi; Society for Neuroscience; and Takeda Development Center Americas, Inc. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for this project.

International Standard Book Number-13: 978-0-309-45026-3
International Standard Book Number-10: 0-309-45026-8
Digital Object Identifier: 10.17226/23657

Additional copies of this publication are available for sale from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

Copyright 2017 by the National Academy of Sciences. All rights reserved.

Printed in the United States of America

Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2017. Developing multimodal therapies for brain disorders: Proceedings of a workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
×

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The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

The National Academy of Engineering was established in 1964 under the charter of the National Academy of Sciences to bring the practices of engineering to advising the nation. Members are elected by their peers for extraordinary contributions to engineering. Dr. C. D. Mote, Jr., is president.

The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president.

The three Academies work together as the National Academies of Sciences, Engineering, and Medicine to provide independent, objective analysis and advice to the nation and conduct other activities to solve complex problems and inform public policy decisions. The National Academies also encourage education and research, recognize outstanding contributions to knowledge, and increase public understanding in matters of science, engineering, and medicine.

Learn more about the National Academies of Sciences, Engineering, and Medicine at www.national-academies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Reports document the evidence-based consensus of an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and committee deliberations. Reports are peer reviewed and are approved by the National Academies of Sciences, Engineering, and Medicine.

Proceedings chronicle the presentations and discussions at a workshop, symposium, or other convening event. The statements and opinions contained in proceedings are those of the participants and have not been endorsed by other participants, the planning committee, or the National Academies of Sciences, Engineering, and Medicine.

For information about other products and activities of the National Academies, please visit nationalacademies.org/whatwedo.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
×

PLANNING COMMITTEE ON MULTIMODAL THERAPIES FOR BRAIN DISORDERS1

KARL KIEBURTZ (Co-Chair), University of Rochester Medical Center

SARAH H. LISANBY (Co-Chair), National Institute of Mental Health

ROBERT ALEXANDER, Pfizer Inc.

TIM DENISON, Medtronic Inc.

JAMES HENDRIX, Alzheimer’s Association

THINH NGUYEN, Food and Drug Administration

DAVID SHURTLEFF, National Center for Complementary and Integrative Health

TIMOTHY STRAUMAN, Duke University

STEVIN ZORN, MindImmune Therapeutics, Inc.

Health and Medicine Division (HMD) Staff

CLARE STROUD, Forum Director

SHEENA M. POSEY NORRIS, Program Officer

NOAM I. KEREN, Associate Program Officer (from June 2016)

JOANNA ROBERTS, Senior Program Assistant (until April 2016)

ANDREW M. POPE, Director, Board on Health Sciences Policy

___________________

1The National Academies of Sciences, Engineering, and Medicine’s planning committees are solely responsible for organizing the workshop, identifying topics, and choosing speakers. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
×

FORUM ON NEUROSCIENCE AND NERVOUS SYSTEM DISORDERS1

STEVEN HYMAN (Chair), Broad Institute of Massachusetts Institute of Technology and Harvard University

STORY LANDIS (Vice Chair), Director Emeritus, National Institute of Neurological Disorders and Stroke

SUSAN AMARA, Society for Neuroscience

RITA BALICE-GORDON, Sanofi

KATJA BROSE, Cell Press

EMERY BROWN, Harvard Medical School and Massachusetts Institute of Technology

DANIEL BURCH, Pharmaceutical Product Development, LLC

SARAH CADDICK, Gatsby Charitable Foundation

ROSA CANET-AVILES, Foundation for the National Institutes of Health

MARIA CARRILLO, Alzheimer’s Association

KAREN CHANDROSS, Sanofi (until June 2016)

E. ANTONIO CHIOCCA, Harvard Medical School

TIMOTHY COETZEE, National Multiple Sclerosis Society

JONATHAN COHEN, Princeton University

FAY LOMAX COOK, National Science Foundation

BRUCE CUTHBERT, National Institute of Mental Health (until September 2016)

BILLY DUNN, Food and Drug Administration

EMMELINE EDWARDS, National Center for Complementary and Integrative Health (until September 2016)

JOSHUA GORDON, National Institute of Mental Health (from September 2016)

HANK GREELY, Stanford University

RAQUEL GUR, University of Pennsylvania

MAGALI HAAS, Cohen Veterans Bioscience

RAMONA HICKS, One Mind

RICHARD HODES, National Institute on Aging

STUART HOFFMAN, U.S. Department of Veterans Affairs

MICHAEL IRIZARRY, Eli Lilly and Company

___________________

1The National Academies of Sciences, Engineering, and Medicine’s forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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INEZ JABALPURWALA, Brain Canada Foundation

FRANCES JENSEN, University of Pennsylvania

GEORGE KOOB, National Institute on Alcohol Abuse and Alcoholism

WALTER KOROSHETZ, National Institute of Neurological Disorders and Stroke

ALAN LESHNER, American Association for the Advancement of Science (Emeritus)

HUSSEINI MANJI, Janssen Research & Development, LLC

DAVID MICHELSON, Merck Research Laboratories

PATRICIO O’DONNELL, Pfizer Inc.

JAMES OLDS, National Science Foundation

ATUL PANDE, Tal Medical

STEVEN PAUL, Voyager Therapeutics, Inc.

RODERIC PETTIGREW, National Institute of Biomedical Imaging and Bioengineering (from September 2016)

EMILIANGELO RATTI, Takeda Pharmaceuticals International

TODD SHERER, The Michael J. Fox Foundation for Parkinson’s Research

DAVID SHURTLEFF, National Center for Complementary and Integrative Health

PAUL SIEVING, National Eye Institute

NORA VOLKOW, National Institute on Drug Abuse

STEVIN ZORN, MindImmune Therapeutics, Inc.

HMD Staff

CLARE STROUD, Forum Director

SHEENA M. POSEY NORRIS, Program Officer

NOAM I. KEREN, Associate Program Officer (from June 2016)

JOANNA ROBERTS, Senior Program Assistant (until April 2016)

DANIEL FLYNN, Senior Program Assistant (from September 2016)

JIM BANIHASHEMI, Financial Officer

HILARY BRAGG, Program Coordinator

ANDREW M. POPE, Director, Board on Health Sciences Policy

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
×

Reviewers

This Proceedings of a Workshop has been reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the institution in making its published Proceedings of a Workshop as sound as possible and to ensure that the Proceedings of a Workshop meets institutional standards for objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the process. We wish to thank the following individuals for their review of this Proceedings of a Workshop:

BRUCE BEBO, National Multiple Sclerosis Society

BRIAN FISKE, The Michael J. Fox Foundation for Parkinson’s Research

KEITH HILDEBRAND, Medtronic, Inc.

ROGER J. LEWIS, David Geffen School of Medicine at UCLA

HELEN S. MAYBERG, Emory University School of Medicine

Although the reviewers listed above have provided many constructive comments and suggestions, they did not see the final draft of the Proceedings of a Workshop before its release. The review of this Proceedings of a Workshop was overseen by JOSEPH T. COYLE, Harvard Medical School. He was responsible for making certain that an independent examination of this Proceedings of a Workshop was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of this Proceedings of a Workshop rests entirely with the rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2017. Developing Multimodal Therapies for Brain Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/23657.
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Multimodal therapy approaches that combine interventions aimed at different aspects of disease are emerging as potential—and perhaps essential—ways to enhance clinical outcomes for patients with psychiatric and neurological disorders. In order to examine the general principles underlying multimodal therapies and to explore challenges, potential barriers, and opportunities for their development, the National Academies of Sciences, Engineering, and Medicine convened a workshop in June 2016. Participants explored scientific, clinical, regulatory, and reimbursement issues related to multimodal approaches and potential opportunities to enhance clinical outcomes for individuals with nervous system disorders. This publication summarizes the presentations and discussions from the workshop.

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