Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
Appendix A
Workshop Agenda
ANIMAL MODELS FOR MICROBIOME RESEARCH:
ADVANCING BASIC AND TRANSLATIONAL SCIENCE
A WORKSHOP OF THE ROUNDTABLE ON SCIENCE AND WELFARE IN LABORATORY ANIMAL USE
December 19-20, 2016
500 Fifth Street NW, Washington DC 20001
National Academies of Sciences, Engineering, and Medicine
Keck Center, Room 100
MONDAY, DECEMBER 19
(Gnotobiotic) Model Organisms and Microbiome Research:
Choices, Challenges, and Proposed Solutions
| 7:30–9:00 am | Registration |
| 9:00 | Animal Models and Microbiome Research: A Trans-Kingdom Perspective Herbert “Skip” Virgin, Washington University |
| 9:45 | Coffee Break |
| 10:00 | Session 1-1. Non-Rodent Animal Models for Microbiome Research Much of current microbiome research has focused on mouse models. As with other branches of preclinical research, exploring the microbiome in other species complements and advances knowledge gleaned from mice. This session will provide perspectives on the benefits and limitations of some of these animal models. |
| C. Elegans - Buck Samuel, Baylor College of Medicine Drosophila - Angela Douglas, Cornell University Zebrafish - Karen Guillemin, University of Oregon Piglets - Jeff Gordon, Washington University (Planning Committee Member) (remotely) |
|
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
| 12:00 pm | Lunch (Will not be provided. There is a cafeteria on the third floor of the Keck Center.) |
| 1:00 | Session 1-2. In Vitro Systems for Characterizing the Properties/Dynamic Operations of Microbial Consortia One of the benefits stemming from advances in in vitro systems is the opportunity to reduce the number of animals needed to develop and test hypotheses, and in some cases replace their use entirely. Speakers in this session will present three non-animal systems for microbiome research, including thoughts on their ability to complement animal use now and in the future. |
| Bioreactors - Robert Britton, Baylor College of Medicine Organoids - Vincent Young, University of Michigan (Planning Committee Member) Microfluidics: Human organs on chips - Donald Ingber, Wyss Institute at Harvard University (remotely) |
|
| 2:30 | Coffee Break |
| 2:45 | Session 1-3. Modeling Human Microbiota in Animal Systems Animal models provide opportunities to define the contributions of members of the microbiota to community function and the mechanisms through which they affect various aspects of host biology. This session illustrates current approaches that are being used and how these approaches may be advanced to promote further basic and translational research in this field. |
A. Connecting Microbes to Metabolism Using Gnotobiotic Models
|
|
| 5:45 pm | Adjourn |
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
TUESDAY, DECEMBER 20
Methodological Challenges in Characterizing Gnotobiotic Animal Models
| 9:00 am | Session 2-1. Reproducibility: Within and Across Experiments |
| Creating Stabilized and Defined Microbiomes in Laboratory Animals Andrew Macpherson, University Hospital, Bern, Switzerland | |
| 9:45 | Coffee Break |
| 10:00 | The role of host genetics - Aldons J. Lusis, University of California, Los Angeles |
| The role of immunological variation - Jeremiah Faith, Icahn School of Medicine at Mount Sinai | |
| The role of diets: Standardization and characterization - Gary Wu, University of Pennsylvania | |
| The role of gender - Alexander Chervonsky, The University of Chicago | |
| 12:00 pm | Lunch (Will not be provided. There is a cafeteria on the third floor of the Keck Center.) |
| 1:00 | Session 2-2. Establishing and Evolving Gnotobiotic Facilities and Their Technologies: Examining the Present and Looking to the Future Establishing the necessary infrastructure for microbiome research is challenging. How can a successful gnotobiotic facility be planned? What are some of the attributes that can ensure sustainability, community sharing, and support of such a facility (including rederivation and “archiving” of animals as germ-free)? The speakers will share their experiences regarding challenges and solutions encountered. They will also focus on advances in the support systems and facility operations that enable animal care personnel to provide for the improved well-being of the specialized animals used in microbiome research. |
| Establishing a new gnotobiotic facility: Education, missions, and accommodating success - Timothy Hand, University of Pittsburgh | |
| Evolving an established gnotobiotic facility - R. Balfour Sartor, University of North Carolina at Chapel Hill | |
| Complex gnotobiology: An emerging paradigm in the era of next-generation sequencing - Craig Franklin, University of Missouri | |
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
| Alternatives to gnotobiotics: Normalizing the environment - Stephen Jameson, University of Minnesota | |
| Veterinary management challenges and future directions, including technical considerations for imaging and surgery in gnotobiotic animals - Betty Theriault, The University of Chicago | |
| Unique challenges and future directions related to managing mouse gnotobiotic husbandry facilities - Chriss J. Vowles, University of Michigan | |
| 4:30 | Overview of Workshop Joseph Newsome and Vincent Young |
| 5:00 pm | Adjourn |
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2018. Animal Models for Microbiome Research: Advancing Basic and Translational Science: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/24858.
×
