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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

Advancing Therapeutic
Development for Pain and Opioid
Use Disorders Through Public–Private
Partnerships

PROCEEDINGS OF A WORKSHOP

Lisa Bain, Sheena M. Posey Norris, and Clare Stroud,
Rapporteurs

Forum on Neuroscience and
Nervous System Disorders

Board on Health Sciences Policy

Health and Medicine Division

images

THE NATIONAL ACADEMIES PRESS
Washington, DC
www.nap.edu

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

THE NATIONAL ACADEMIES PRESS 500 Fifth Street, NW Washington, DC 20001

This activity was supported by contracts between the National Academy of Sciences and the Alzheimer’s Association; Brain Canada Foundation; Cohen Veterans Bioscience; Department of Health and Human Services’ Food and Drug Administration (5R13FD005362-02) and National Institutes of Health (NIH) (HHSN26300089 [Under Master Base #DHHS-10002880]) through the National Center for Complementary and Integrative Health, National Eye Institute, National Institute of Mental Health, National Institute of Neurological Disorders and Stroke, National Institute on Aging, National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse, and NIH Blueprint for Neuroscience Research; Department of Veterans Affairs (VA240-14-C-0057); Eli Lilly and Company; Foundation for the National Institutes of Health; Gatsby Charitable Foundation; George and Anne Ryan Institute for Neuroscience at The University of Rhode Island; Janssen Research & Development, LLC; Lundbeck Research USA; Merck Research Laboratories; The Michael J. Fox Foundation for Parkinson’s Research; National Multiple Sclerosis Society; National Science Foundation (BCS-1064270); One Mind; Pfizer Inc.; Pharmaceutical Product Development, LLC; Sanofi; Society for Neuroscience; Takeda Pharmaceuticals International, Inc.; and Wellcome Trust. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for this project.

International Standard Book Number-13: 978-0-309-47399-6
International Standard Book Number-10: 0-309-47399-3
Digital Object Identifier: https://doi.org/10.17226/25060

Additional copies of this publication are available for sale from the National Academies Press, 500 Fifth Street, NW, Keck 360, Washington, DC 20001; (800) 624-6242 or (202) 334-3313; http://www.nap.edu.

Copyright 2018 by the National Academy of Sciences. All rights reserved.

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Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2018. Advancing therapeutic development for pain and opioid use disorders through publicprivate partnerships: Proceedings of a workshop. Washington, DC: The National Academies Press. doi: https://doi.org/10.17226/25060.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

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The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

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Learn more about the National Academies of Sciences, Engineering, and Medicine at www.nationalacademies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

Image

Consensus Study Reports published by the National Academies of Sciences, Engineering, and Medicine document the evidence-based consensus on the study’s statement of task by an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and the committee’s deliberations. Each report has been subjected to a rigorous and independent peer-review process and it represents the position of the National Academies on the statement of task.

Proceedings published by the National Academies of Sciences, Engineering, and Medicine chronicle the presentations and discussions at a workshop, symposium, or other event convened by the National Academies. The statements and opinions contained in proceedings are those of the participants and are not endorsed by other participants, the planning committee, or the National Academies.

For information about other products and activities of the National Academies, please visit www.nationalacademies.org/about/whatwedo.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

PLANNING COMMITTEE ON ADVANCING THERAPEUTIC DEVELOPMENT FOR PAIN AND OPIOID USE DISORDERS THROUGH PUBLIC–PRIVATE PARTNERSHIPS1

WALTER KOROSHETZ (Co-Chair), National Institute of Neurological Disorders and Stroke

STORY LANDIS (Co-Chair), Director Emeritus, National Institute of Neurological Disorders and Stroke

NORA VOLKOW (Co-Chair), National Institute on Drug Abuse

ANDREW AHN, Eli Lilly and Company

KATJA BROSE, Chan Zuckerberg Initiative

JOHN DUNLOP, Amgen

ROBERT DWORKIN, University of Rochester

SHARON HERTZ, Food and Drug Administration

LINDA PORTER, National Institute of Neurological Disorders and Stroke

TARAK SAMAD, Pfizer Inc.

FRIEDHELM SANDBRINK, Department of Veterans Affairs

ROBERT SHIBUYA, Food and Drug Administration

DAVID SHURTLEFF, National Center for Complementary and Integrative Health

JACK STEIN, National Institute on Drug Abuse

JAMES SULLIVAN, AbbVie Inc.

CHRISTIN VEASLEY, Chronic Pain Research Alliance

TONY YAKSH, University of California, San Diego

Health and Medicine Division Staff

CLARE STROUD, Forum Director

SHEENA M. POSEY NORRIS, Program Officer

NOAM I. KEREN, Associate Program Officer

DANIEL FLYNN, Research Assistant

ANDREW M. POPE, Director, Board on Health Sciences Policy

___________________

1 The National Academies of Sciences, Engineering, and Medicine’s planning committees are solely responsible for organizing the workshop, identifying topics, and choosing speakers. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

FORUM ON NEUROSCIENCE AND NERVOUS SYSTEM DISORDERS1

STEVEN HYMAN (Chair), Broad Institute of Massachusetts Institute of Technology and Harvard University

STORY LANDIS (Vice Chair), Director Emeritus, National Institute of Neurological Disorders and Stroke

SUSAN AMARA, Society for Neuroscience

RITA BALICE-GORDON, Sanofi

KATJA BROSE, Chan Zuckerberg Initiative

EMERY BROWN, Harvard Medical School and Massachusetts Institute of Technology

JOSEPH BUXBAUM, Icahn School of Medicine at Mount Sinai

SARAH CADDICK, Gatsby Charitable Foundation

ROSA CANET-AVILES, Foundation for the National Institutes of Health

MARIA CARRILLO, Alzheimer’s Association

E. ANTONIO CHIOCCA, Harvard Medical School

TIMOTHY COETZEE, National Multiple Sclerosis Society

JONATHAN COHEN, Princeton University

FAY LOMAX COOK, National Science Foundation

JAMES DESHLER, National Science Foundation

BILLY DUNN, Food and Drug Administration

MICHAEL EGAN, Merck Research Laboratories

JOSHUA GORDON, National Institute of Mental Health

HANK GREELY, Stanford University

RAQUEL GUR, University of Pennsylvania

MAGALI HAAS, Cohen Veterans Bioscience

RAMONA HICKS, One Mind

RICHARD HODES, National Institute on Aging

STUART HOFFMAN, Department of Veterans Affairs

MICHAEL IRIZARRY, Eli Lilly and Company

INEZ JABALPURWALA, Brain Canada Foundation

FRANCES JENSEN, University of Pennsylvania

GEORGE KOOB, National Institute on Alcohol Abuse and Alcoholism

___________________

1 The National Academies of Sciences, Engineering, and Medicine’s forums and roundtables do not issue, review, or approve individual documents. The responsibility for the published Proceedings of a Workshop rests with the workshop rapporteurs and the institution.

Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

WALTER KOROSHETZ, National Institute of Neurological Disorders and Stroke

JOHN KRYSTAL, Yale University

ALAN LESHNER, American Association for the Advancement of Science (Emeritus)

HUSSEINI MANJI, Janssen Research & Development, LLC

DAVID MICHELSON, Merck Research Laboratories (until December 2017)

JAMES OLDS, National Science Foundation (until December 2017)

ATUL PANDE, Tal Medical

STEVEN PAUL, Voyager Therapeutics, Inc.

STEPHEN PEROUTKA, Pharmaceutical Product Development, LLC

RODERIC PETTIGREW, National Institute of Biomedical Imaging and Bioengineering (until November 2017)

EMILIANGELO RATTI, Takeda Pharmaceuticals International

TAREK SAMAD, Pfizer Inc. (until December 2017)

DOUGLAS SHEELEY, National Institute of Dental and Craniofacial Research

TODD SHERER, The Michael J. Fox Foundation for Parkinson’s Research

DAVID SHURTLEFF, National Center for Complementary and Integrative Health

PAUL SIEVING, National Eye Institute

NORA VOLKOW, National Institute on Drug Abuse

ANDREW WELCHMAN, Wellcome Trust

DOUG WILLIAMSON, Lundbeck

STEVIN ZORN, MindImmune Therapeutics, Inc.

Health and Medicine Division Staff

CLARE STROUD, Forum Director

SHEENA M. POSEY NORRIS, Program Officer

NOAM I. KEREN, Associate Program Officer

DANIEL FLYNN, Research Assistant

JIM BANIHASHEMI, Financial Officer (until October 2017)

BARDIA MASSOUDKHAN, Financial Associate (from October 2017)

ANDREW M. POPE, Director, Board on Health Sciences Policy

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

Reviewers

This Proceedings of a Workshop was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published proceedings as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.

We thank the following individuals for their review of this proceedings:

CHAD MICHAEL BRUMMETT, University of Michigan

KATHERINE DAWSON, Biogen

LUDA DIATCHENKO, McGill University

MICHAEL OSHINSKY, National Insitute of Neurological Disorders and Stroke

HOWARD B. ROSEN, Independent Consultant

KENNETH VERBURG, Pfizer Inc.

Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the content of the proceedings nor did they see the final draft before its release. The review of this proceedings was overseen by SARA ROSENBAUM, The George Washington University, and BRADFORD H. GRAY, The Urban Institute. They were responsible for making certain that an independent examination of this proceedings was carried out in accordance with

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×

standards of the National Academies and that all review comments were carefully considered. Responsibility for the final content rests entirely with the rapporteurs and the National Academies.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R2
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R3
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R4
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R5
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R6
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R7
Page viii Cite
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R8
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R9
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R10
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R11
Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2018. Advancing Therapeutic Development for Pain and Opioid Use Disorders Through Public-Private Partnerships: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25060.
×
Page R12
Next: 1 Introduction and Background »
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Chronic pain is one of the most prevalent, costly, and disabling health conditions in the United States. Estimates show that more than 11 percent of the American population suffer from chronic pain, yet the federal pain research investment has been minimal. In parallel with a gradual increased recognition of the problems of treating chronic pain, the opioid epidemic has emerged as a growing public health emergency. The intersection of these two crises lies in the fact that an unintended consequence of treating pain has been an increasing number of opioid prescriptions and diversion of drugs for illicit purposes.

In May 2017, the National Institutes of Health (NIH), and the National Institute on Drug Abuse announced a public–private partnership to develop solutions to the opioid crisis and cut in half the time it takes to develop non-addictive analgesics. To advance the planning of NIH’s anticipated public–private partnerships, the National Academies’ Forum on Neuroscience and Nervous Systems Disorders hosted a public workshop that brought together a diverse group of stakeholders from academia, federal agencies, advocacy organizations and companies developing therapeutics for pain and opioid use disorders. Participants discussed potential strategies to accelerate development of non-addictive pain medications and treatments for opioid use disorders. This publication summarizes the presentations and discussions from the workshop.

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