Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
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Appendix A
Workshop Agenda
Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing–Based Biomedical Research
A Roundtable on Science and Welfare in Laboratory Animal Use Workshop
October 22–23, 2018
Keck Center Room 100
500 Fifth Street, NW
Washington, DC 20001
WORKSHOP CONTEXT
The New World primate, the common marmoset (Callithrix jacchus), is a research model of increasing importance for biomedical research in the United States and globally. Marmosets present certain advantages compared to more traditional nonhuman primate species and may be particularly useful for the development of new disease models using genetic engineering (achieved using the CRISPR/Cas9 technology) and assisted reproductive technologies. Germline transmission of a transgene in marmosets was first shown in 2009 while mapping of their genome was published in 2014. Production of transgenic models of disease in marmosets is currently being tested in the United States and Japan, among others. However, a number
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
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of concerns have been voiced with respect to the increasing popularity of marmoset animal models based on the advent of genetic engineering/gene editing. Planned by an ad hoc committee, the Roundtable on Science and Welfare in Laboratory Animal Use will host a public workshop to explore and address these concerns.
WORKSHOP OBJECTIVES
Invited experts and speakers from academia, industry, nonprofit organizations, and government agencies will convene for this 2-day public workshop to
- Examine the availability of marmosets in the United States and abroad.
- Discuss animal welfare and ethical considerations stemming from the use of wildtype and genetically modified marmosets.
- Discuss standards of housing and care, dietary needs, and feeding requirements for wildtype as well as genetically modified marmosets in captivity.
- The presentations and discussions at the workshop will be captured in a workshop proceedings.
AGENDA
| MONDAY, October 22, 2018, Keck 100 | ||
| 8:00AM | Welcome and Introduction to Workshop | |
| Workshop Co-Chairs: SAVERIO CAPUANO, Wisconsin National Primate Research Center |
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| JAMES FOX, Massachusetts Institute of Technology Roundtable Director | ||
| LIDA ANESTIDOU, Institute for Laboratory Animal Research | ||
| 8:10AM | Keynote: The Historical Use of Callitrichids in Biomedical Research and Current Trends Introduction | SUZETTE TARDIF, Southwest National Primate Research Center |
| JAMES FOX | ||
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Session 1—Marmoset Availability
| 8:40AM | Current State of Affairs: Analyzing the Numbers | Session Moderator: SAVERIO CAPUANO |
Objectives:
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| Speakers: JON LEVINE, Wisconsin Nati Center ERIKA SASAKI, Central Institute for Experimental Animals, Japan MARIA ADÉLIA BORSTELMANN DE OLIVEIRA, Federal Rural University of Pernambuco, Brazil SAVERIO CAPUANO |
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| Q&A with the audience | ||
| 10:10AM | COFFEE BREAK | |
| 10:30AM | Genetic Diversity in Times of Increased Demand | Session Moderator: JAMES PICKEL, National Institute of Mental Health |
Objectives:
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Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
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|
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| Speakers: KENTON KERNS, Smithsonian National Zoo & Conservation Biology Institute JOANNA MALUKIEWICZ, Arizona State University YASUHIRO GO, National Institute of Physiology, Japan JEFFREY ROGERS, Baylor College of Medicine RICARDO DEL ROSARIO, Broad Institute |
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| 11:45AM | Maintain and Track Genetic Diversity in Marmoset Colonies—Facilitated Discussion with the Audience | Session Leader: JAMES PICKEL |
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Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
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| 12:30PM | LUNCH (Lunch will not be provided. There is a cafeteria on the 3rd floor of this building.) | |
Session 2—Marmosets as Research Models
| 1:30PM | Using Marmosets in Biomedical Research | Session Moderator: MARINA EMBORG, Wisconsin National Primate Research Center |
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Objectives: In order to showcase the versatility of marmosets as animal models, panelists will use examples of different research questions to discuss
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| Speakers: CORINNA ROSS, Texas A&M University, San Antonio JEAN PATTERSON, Texas Biomedical Research Institute JAN LANGERMANS, Biomedical Primate Research Centre, The Netherlands ERIKA SASAKI AFONSO SILVA, National Institute of Neurological Disorders and Stroke |
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| Q&A with the audience | ||
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
| 3:30PM | COFFEE BREAK | |
| 3:45PM | Ethical Considerations Regarding the Use of Marmosets in Research | Session Overview: ERIC HUTCHINSON, Johns Hopkins University |
Objectives:
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| Speakers: ADAM SHRIVER, Oxford University, United Kingdom STEVEN NIEMI, Harvard University |
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| 4:45PM | Facilitated Discussion with the Audience | Session Leader: ERIC HUTCHINSON |
| 5:30PM | End of Day 1 | |
| TUESDAY, October 23, 2018, Keck 100 | ||
| 8:15AM | Opening of Day 2 and Recap of Day 1 | SAVERIO CAPUANO |
| 8:30AM | Highlights of the workshop on Transgenic and Chimeric Neuroscience Research: Exploring the Scientific Opportunities Afforded by New Nonhuman Primate Models | MARINA EMBORG |
Session 3—Marmoset Husbandry
| 8:45AM | Select Topics in Marmoset Husbandry | Session Moderator: JACO BAKKER, Biomedical Primate Research Centre, The Netherlands |
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Objectives:
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| Speakers: MICHAEL POWER, Smithsonian National Zoo & Conservation Biology Institute NANCY CAINE, California State University, San Marcos DAVID ABBOTT, Wisconsin National Primate Research Center TAKASHI INOUE, Central Institute for Experimental Animals, Japan JACO BAKKER |
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| 10:25AM | Facilitated Discussion with the Audience | Session Leaders: JACO BAKKER SUZETTE TARDIF |
There is considerable variation in the husbandry and management of marmosets. Such variation may impede efficient and effective use of this species as a research model and may lead to irreproducible studies.
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Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
| 12:00PM | LUNCH (Lunch will not be provided. There is a cafeteria on the 3rd floor of this building.) | |
Session 4—Marmoset Veterinary/Clinical Care
| 1:00PM | Select Topics in Marmoset Veterinary Care | Session Moderator: ERIC HUTCHINSON |
Objectives:
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| Speakers: CASEY FITZ, Wisconsin National Primate Research Center JESSICA IZZI, Johns Hopkins University ANNA GOODROE, University of Houston MONIKA BURNS, Massachusetts Institute of Technology KEITH MANSFIELD, Novartis |
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| 2:40PM | Facilitated Discussion with the Audience | Session Leader: ERIC HUTCHINSON |
Session 5—Improving Research Practices That Depend on the Use of Marmosets: Key Messages and Future Actions
| 4:00PM | Closing Session—Improving Research Practices That Depend on the Use of Marmosets: Key Messages and Future Actions | Session Leaders: SAVERIO CAPUANO JAMES FOX |
| 4:30–4:45PM | Workshop Adjourns | |
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
Suggested Citation:"Appendix A: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2019. Care, Use, and Welfare of Marmosets as Animal Models for Gene Editing-Based Biomedical Research: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25356.
×
