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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Next Steps for
Functional Genomics

PROCEEDINGS OF A WORKSHOP

Robert Pool, Steven M. Moss, and Frances Sharples, Rapporteurs

Board on Life Sciences

Division on Earth and Life Studies

images

THE NATIONAL ACADEMIES PRESS
Washington, DC
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Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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This activity was supported by the National Science Foundation under Award Number 1927620. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.

International Standard Book Number-13: 978-0-309-67673-1
International Standard Book Number-10: 0-309-67673-8
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Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/25780.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
×

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The National Academy of Sciences was established in 1863 by an Act of Congress, signed by President Lincoln, as a private, nongovernmental institution to advise the nation on issues related to science and technology. Members are elected by their peers for outstanding contributions to research. Dr. Marcia McNutt is president.

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The National Academy of Medicine (formerly the Institute of Medicine) was established in 1970 under the charter of the National Academy of Sciences to advise the nation on medical and health issues. Members are elected by their peers for distinguished contributions to medicine and health. Dr. Victor J. Dzau is president.

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Learn more about the National Academies of Sciences, Engineering, and Medicine at www.nationalacademies.org.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Consensus Study Reports published by the National Academies of Sciences, Engineering, and Medicine document the evidence-based consensus on the study’s statement of task by an authoring committee of experts. Reports typically include findings, conclusions, and recommendations based on information gathered by the committee and the committee’s deliberations. Each report has been subjected to a rigorous and independent peer-review process and it represents the position of the National Academies on the statement of task.

Proceedings published by the National Academies of Sciences, Engineering, and Medicine chronicle the presentations and discussions at a workshop, symposium, or other event convened by the National Academies. The statements and opinions contained in proceedings are those of the participants and are not endorsed by other participants, the planning committee, or the National Academies.

For information about other products and activities of the National Academies, please visit www.nationalacademies.org/about/whatwedo.

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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PLANNING COMMITTEE ON NEXT STEPS FOR FUNCTIONAL GENOMICS: A WORKSHOP

GENE E. ROBINSON (NAS, NAM), Chair, University of Illinois at Urbana-Champaign

PHILIP N. BENFEY (NAS), Duke University

CHARLES DANKO, Cornell University

EMMA FARLEY, University of California, San Diego

TRUDY F. C. MACKAY (NAS), Clemson University

TERRY MAGNUSON (NAM), University of North Carolina at Chapel Hill

LAUREN O’CONNELL, Stanford University

ANDREA SWEIGART, University of Georgia

Staff

STEVEN M. MOSS, Associate Program Officer, Board on Life Sciences

FRANCES SHARPLES, Board Director, Board on Life Sciences

KOSSANA YOUNG, Senior Program Assistant, Board on Life Sciences

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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BOARD ON LIFE SCIENCES

JAMES P. COLLINS, Chair, Arizona State University

A. ALONSO AGUIRRE, George Mason University

VALERIE H. BONHAM, Ropes & Gray LLP

DOMINIQUE BROSSARD, University of Wisconsin–Madison

NANCY D. CONNELL, Johns Hopkins Center for Health Security

SEAN M. DECATUR, Kenyon College

JOSEPH R. ECKER, Salk Institute for Biological Studies

SCOTT V. EDWARDS, Harvard University

GERALD EPSTEIN, National Defense University

ROBERT J. FULL, University of California, Berkeley

MARY E. MAXON, Lawrence Berkeley National Laboratory

ROBERT NEWMAN, Independent Consultant

STEPHEN J. O’BRIEN, Nova Southeastern University

LUCILA OHNO-MACHADO, University of California, San Diego

CLAIRE POMEROY, Albert and Mary Lasker Foundation

MARY E. POWER, University of California, Berkeley

SUSAN RUNDELL SINGER, Rollins College

LANA SKIRBOLL, Sanofi

DAVID R. WALT, Harvard Medical School

PHYLLIS M. WISE, University of Colorado Boulder

Staff

FRANCES SHARPLES, Director

KATIE BOWMAN, Senior Program Officer

ANDREA HODGSON, Program Officer

JO HUSBANDS, Senior Scholar

KEEGAN SAWYER, Senior Program Officer

AUDREY THEVENON, Program Officer

STEVEN M. MOSS, Associate Program Officer

JESSICA DE MOUY, Senior Program Assistant

KOSSANA YOUNG, Senior Program Assistant

Suggested Citation:"Front Matter." National Academies of Sciences, Engineering, and Medicine. 2020. Next Steps for Functional Genomics: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/25780.
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Reviewers

This Proceedings of a Workshop was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published proceedings as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.

We thank the following individuals for their review of this proceedings:

JULIA BAILEY-SERRES, University of California, Riverside

EMMA FARLEY, University of California, San Diego

MARC HALFON, University at Buffalo-SUNY

STEVEN HENIKOFF, Fred Hutchinson Cancer Research Center

Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the content of the proceedings nor did they see the final draft before its release. The review of this proceedings was overseen by JASPER RINE, University of California, Berkeley. He was responsible for making certain that an independent examination of this proceedings was carried out in accordance with standards of the National Academies and that all review comments were carefully considered. Responsibility for the final content rests entirely with the rapporteurs and the National Academies.

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One of the holy grails in biology is the ability to predict functional characteristics from an organism's genetic sequence. Despite decades of research since the first sequencing of an organism in 1995, scientists still do not understand exactly how the information in genes is converted into an organism's phenotype, its physical characteristics. Functional genomics attempts to make use of the vast wealth of data from "-omics" screens and projects to describe gene and protein functions and interactions. A February 2020 workshop was held to determine research needs to advance the field of functional genomics over the next 10-20 years. Speakers and participants discussed goals, strategies, and technical needs to allow functional genomics to contribute to the advancement of basic knowledge and its applications that would benefit society. This publication summarizes the presentations and discussions from the workshop.

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