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The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance (2021)

Chapter: Appendix B: Committee Meeting Agendas

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Page 129 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Appendix B

Committee Meeting Agendas

Meeting 1

June 1, 2020

OPEN SESSION

12:30pm Welcome, Introductions, and Meeting Overview
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
12:40 pm Charge to Committee
Speaker:
Carrie Wolinetz, National Institutes of Health
1:30 pm Neural Organoids: The State of the Science
Speaker:
Arnold Kriegstein, University of California, San Francisco
1:50 pm Q&A with Committee
Page 130 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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2:30 pm Neural Chimeras: The State of the Science
Speaker:
Steven Goldman, University of Rochester Medical Center
2:50 pm Q&A with Committee
3:30 pm Adjourn to Closed Session

June 2, 2020

OPEN SESSION

12:00 pm Welcome
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
12:05 pm The Ethics of Neural Organoid and Chimera Research
Speaker:
Nita Farahany, Duke University School of Law
12:25 pm Q&A with Committee
1:00 pm The Regulatory Landscape for Neural Organoid and Chimera Research
Speaker:
I. Glenn Cohen, Harvard Law School
1:20 pm Q&A with Committee
2:00 pm Adjourn to Closed Session
Page 131 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Meeting 2
July 15, 2020

3:00 pm Sponsor Perspective
Speaker:
Steven E. Hyman, Harvard University and Board Chair, Dana Foundation
3:10 pm Discussion with Committee
3:30 pm Improving Scientific Communication about Complex Concepts
Speaker:
Kathleen Hall Jamieson, University of Pennsylvania
3:40 pm Discussion with Committee
4:00 Adjourn to Closed Session

Meeting 3
August 10, 2020

OPEN SESSION

Framing Questions for Meeting Discussions:
  • How would researchers define or identify enhanced or human awareness in a chimeric animal?
  • Do research animals with enhanced capabilities require different treatment compared to typical animal models? What are appropriate disposal mechanisms for such models?
  • How large or complex would the ex vivo brain organoids need to be to attain enhanced or human awareness?
1:00 pm Welcome, Introductions, and Meeting Overview
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
Page 132 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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1:05 pm Consciousness and Awareness
Speakers:
Anil Seth, University of Sussex
Christof Koch, Allen Institute for Brain Science
Eva Jablonka, Tel-Aviv University
1:45 pm Q&A with Committee
2:30 pm Break
2:45 pm Understanding and Measuring Consciousness in Animals
Speakers:
David DeGrazia, George Washington University
Frans B. M. de Waal, Emory University
3:15 pm Q&A with Committee
4:00 pm States of Consciousness in Humans
Speakers:
Emery Brown, Massachusetts Institute of Technology
Brian Edlow, Massachusetts General Hospital
4:30 pm Q&A with Committee
5:30 pm Adjourn

August 11, 2020

OPEN SESSION

12:00 pm Welcome
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
12:05 pm Understanding and Measuring Pain in Animals
Speakers:
Megan Albertelli, Stanford University
Allan Basbaum, University of California, San Francisco
Page 133 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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12:35 pm Q&A with Committee
1:15 pm Break / Adjourn to Closed Session

Meeting 4
September 25, 2020

OPEN SESSION

12:00 pm Welcome
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
12:10 pm Neural Chimeras and Organoids and Other Human Organoids: Research Methods and Materials
Speakers:
Bjoern Schwer, University of California, San Francisco
Sergiu Pasca, Stanford University
Gordana Vunjak-Novakovic, Columbia University
1:15 pm Discussion with Committee
2:00 pm Break
2:15 pm Nonhuman Primate Neural Research
Speakers:
Mu-Ming Poo, Institute of Neuroscience of the Chinese Academy of Sciences
Guoping Feng, Massachusetts Institute of Technology
3:00 pm Discussion with Committee
4:00 pm Adjourn to Closed Session
Page 134 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Meeting 5
October 29, 2020

OPEN SESSION

12:00 pm Welcome
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
12:15 pm Communication and Engagement with the Public
Speakers:
Dietram Scheufele, University of Wisconsin–Madison
Brad Margus, Cerevance
Evelynn Hammonds, Harvard University
1:00 pm Q&A with Committee
2:00 pm Break
2:15 pm Religious Perspectives, Pt. 1
Speakers:
Sarra Tlili, University of Florida
John Loike, Columbia University
2:45 pm Q&A with Committee
3:30 pm Break and Adjourn to Closed Session

October 30, 2020

OPEN SESSION

1:00 pm Welcome
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
Page 135 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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1:05 pm Religious Perspectives, Pt. 2
Speaker:
Charles Camosy, Fordham University
1:20 pm Q&A with Committee
2:00 pm Break
2:15 pm Animal Welfare
Speakers:
Margaret Landi, GlaxoSmithKline
Joyce Tischler, Lewis & Clark Law School
2:45 pm Q&A with Committee
3:30 pm Break and Adjourn to Closed Session

Meeting 6
November 13, 2020

OPEN SESSION

12:00 pm Welcome
Committee Co-Chairs:
Bernard Lo, The Greenwall Foundation (retired)
Joshua Sanes, Harvard University
12:05 pm Forthcoming ISSCR Guidelines
Speaker:
Insoo Hyun, Case Western Reserve University
12:25 pm Discussion with Committee
1:00 pm Public Engagement and International Governance
Speaker:
Robin Lovell-Badge, The Francis Crick Institute
Page 136 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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1:20 pm Discussion with Committee
1:55 pm Break and Adjourn to Closed Session
3:00 pm Adjourn to Open Session
OPEN SESSION
3:00 pm Mechanism for Governance: NeXTRAC
Speaker:
Margaret Foster Riley, University of Virginia School of Law
3:20 pm Discussion with Committee
4:00 pm International Regulation of Neural Organoids and Chimeras
Speakers:
Valerie Bonham, Ropes & Gray LLP
Mark Barnes, Ropes & Gray LLP
4:30 pm Discussion with Committee
5:00 pm Adjourn to Closed Session

Meeting 7
December 15, 2020

OPEN SESSION

2:00 pm Religious Perspectives, Pt. 3
Moderator:
Bernard Lo, The Greenwall Foundation (retired)
Speaker:
James Peterson, Roanoke College
2:15 pm Q&A with Committee
3:00 pm Adjourn to Closed Session
Page 129 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 129
Page 130 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 130
Page 131 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 131
Page 132 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 132
Page 133 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 133
Page 134 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 134
Page 135 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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Page 135
Page 136 Cite
Suggested Citation:"Appendix B: Committee Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2021. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance. Washington, DC: The National Academies Press. doi: 10.17226/26078.
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The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance Get This Book
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The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance
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Each year, tens of millions of individuals in the U.S. suffer from neurological and psychiatric disorders including neurodegenerative diseases such as Alzheimer's Disease and Parkinson's Disease, and psychiatric disorders such as autism spectrum disorder, depression and schizophrenia. Treatments for these diseases are often completely lacking or only partially effective, due in large part to the difficulty of conducting brain research and the complexity of the brain itself.

Researchers in recent years have developed new models to better represent and study the human brain. The three models considered in this report, all of which generate and use pluripotent stem cells from healthy individuals and patients, are human neural organoids, human neural transplants, and human-animal neural chimeras. The Emerging Field of Human Neural Organoids, Transplants, and Chimeras: Science, Ethics, and Governance reviews the status of research, considers its benefits and risks, discusses associated ethical issues, and considers governance mechanisms for this type of research.

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