QUANTUM SCIENCE CONCEPTS IN
ENHANCING SENSING AND IMAGING
TECHNOLOGIES
APPLICATIONS FOR BIOLOGY
PROCEEDINGS OF A WORKSHOP
Anne Frances Johnson, Steven M. Moss, Andrew Bremer,
and Frances Sharples, Rapporteurs
Board on Life Sciences
Division on Earth and Life Studies
THE NATIONAL ACADEMIES PRESS
Washington, DC
www.nap.edu
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This activity was supported by the Office of Science in the U.S. Department of Energy under Grant No. DE-SC0021108. Any opinions, findings, conclusions, or recommendations expressed in this publication do not necessarily reflect the views of any organization or agency that provided support for the project.
International Standard Book Number-13: 978-0-309-46534-2
International Standard Book Number-10: 0-309-46534-6
Digital Object Identifier: https://doi.org/10.17226/26139
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Copyright 2021 by the National Academy of Sciences. All rights reserved.
Printed in the United States of America
Suggested citation: National Academies of Sciences, Engineering, and Medicine. 2021. Quantum Science Concepts in Enhancing Sensing and Imaging Technologies: Applications for Biology: Proceedings of a Workshop. Washington, DC: The National Academies Press. https://doi.org/10.17226/26139.
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ORGANIZING COMMITTEE FOR WORKSHOP ON QUANTUM SCIENCE CONCEPTS IN ENHANCING SENSING AND IMAGING TECHNOLOGIES: APPLICATIONS FOR BIOLOGY
TAEKJIP “TJ” HA (NAS), Chair, Johns Hopkins University
CLARICE D. AIELLO, University of California, Los Angeles
PREM KUMAR, Northwestern University
PHILIP KURIAN, Howard University
PRINEHA NARANG, Harvard University
JENNIFER PETT-RIDGE, Lawrence Livermore National Laboratory
JASON B. WEST, Texas A&M University
National Academies of Sciences, Engineering, and Medicine Staff
STEVEN M. MOSS, Project Director, Board on Life Sciences
ANDREW BREMER, Associate Program Officer, Board on Life Sciences
ANDREA HODGSON, Senior Program Officer, Board on Life Sciences
KAVITA M. BERGER, Director, Board on Life Sciences
FRANCES SHARPLES, Advisor, Board on Life Sciences
JESSICA DE MOUY, Research Associate, Board on Life Sciences
CHRISTOPHER J. JONES, Senior Program Officer, Board on Physics and Astronomy
ERIK SVEDBERG, Senior Program Officer, National Materials and Manufacturing Board
BOARD ON LIFE SCIENCES
BARBARA A. SCHALL (NAS), Chair, Washington University in St. Louis
A. ALONSO AGUIRRE, George Mason University
VALERIE H. BONHAM, Ropes & Gray LLP
DOMINIQUE BROSSARD, University of Wisconsin–Madison
SEAN M. DECATUR, Kenyon College
SCOTT V. EDWARDS (NAS), Harvard University
GERALD L. EPSTEIN, National Defense University
ROBERT J. FULL, University of California, Berkeley
ROBERT NEWMAN, The Aspen Institute
STEPHEN J. O’BRIEN (NAS), Nova Southeastern University
LUCILA OHNO-MACHADO (NAM), University of California, San Diego
CLAIRE POMEROY, Albert and Mary Lasker Foundation
SUSAN RUNDELL SINGER, Rollins College
DAVID R. WALT (NAE, NAM), Harvard Medical School
PHYLLIS M. WISE (NAM), University of Colorado
National Academies of Sciences, Engineering, and Medicine Staff
KAVITA M. BERGER, Board Director
ANDREW BREMER, Associate Program Officer
NANCY D. CONNELL, Senior Scientist
JESSICA DE MOUY, Research Associate
CYNTHIA GETNER, Financial Business Partner
ANDREA HODGSON, Senior Program Officer
STEVEN M. MOSS, Program Officer
FRAN SHARPLES, Advisor
AUDREY THEVENON, Senior Program Officer
BOARD ON PHYSICS AND ASTRONOMY
ANDREW LANKFORD, Chair, University of California, Irvine
MEIGAN ARONSON, The University of British Columbia
WILLIAM BIALEK (NAS), Princeton University
JILL DAHLBURG, Naval Research Laboratory
SALLY DAWSON, Brookhaven National Laboratory
LOUIS DIMAURO, The Ohio State University
WENDY FREEMAN (NAS), University of Chicago
WENDELL HILL III, University of Maryland
ALAN HURD, Los Alamos National Laboratory
CHUNG-PEI MA, University of California, Berkeley
DAVID H. REITZE, California Institute of Technology
SUNIL SINHA, University of California, San Diego
RISA H. WECHSLER, Kavli Institute of Particle Physics & Cosmology
WILLIAM A. ZAJC, Columbia University
National Academies of Sciences, Engineering, and Medicine Staff
COLLEEN HARTMAN, Board Director
NEERAJ GORKHALY, Associate Program Officer
AMISHA JINANDRA, Associate Program Officer
CHRISTOPHER J. JONES, Senior Program Officer
RADAKA LIGHTFOOT, Financial Business Partner
GREG MACK, Senior Program Officer
DONALD SHAPERO, Senior Scholar
LINDA WALKER, Program Coordinator
NATIONAL MATERIALS AND MANUFACTURING BOARD
THERESA KOTANCHEK, Chair, Evolved Analytics LLC
JOHN KLIER, Vice Chair, University of Massachusetts Amherst
KEVIN ANDERSON (NAE), Brunswick Corporation
CRAIG ARNOLD, Princeton University
TERESA CLEMENT, Raytheon Missile Systems
THOMAS M. DONNELLAN, Applied Research Laboratory
STEPHEN FORREST (NAS, NAE), University of Michigan
AMIT GOYAL (NAE), State University of New York at Buffalo
JULIA GREER, California Institute of Technology
LATONIA M. HARRIS, Janssen Pharmaceuticals
MICK MAHER, Maher & Associates LLC
GREGORY TASSEY, University of Washington
MATTHEW J. ZALUZEC, University of Florida
National Academies of Sciences, Engineering, and Medicine Staff
JAMES LANCASTER, Director
ERIK SVEDBERG, Senior Program Officer
NEERAJ P. GHORKALY, Associate Program Officer
BETH DOLAN, Financial Business Partner
JOSEPH PALMER, Senior Project Assistant
AMISHA JINANDRA, Research Associate
Reviewers
This Proceedings of a Workshop was reviewed in draft form by individuals chosen for their diverse perspectives and technical expertise. The purpose of this independent review is to provide candid and critical comments that will assist the National Academies of Sciences, Engineering, and Medicine in making each published proceedings as sound as possible and to ensure that it meets the institutional standards for quality, objectivity, evidence, and responsiveness to the charge. The review comments and draft manuscript remain confidential to protect the integrity of the process.
We thank the following individuals for their review of this proceedings:
YUN CHEN, Johns Hopkins University
PRINEHA NARANG, Harvard University
GREGORY D. SCHOLES, Princeton University
Although the reviewers listed above provided many constructive comments and suggestions, they were not asked to endorse the content of the proceedings nor did they see the final draft before its release. The review of this proceedings was overseen by MARK SCHNITZER, Stanford University. He was responsible for making certain that an independent examination of this proceedings was carried out in accordance with standards of the National Academies and that all review comments were carefully considered. Responsibility for the final content rests entirely with the rapporteurs and the National Academies.
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Contents
Probing Intracellular and Intercellular Correlations in Biology
Quantum Photonics in Biological Systems
New Quantum Theory Applications for Biology
Quantum-Enabled Electron Microscopy for Biological Study
Quantum Principles for Enhanced Measurement and Imaging in Microscopy
Broadband Spectroscopies of Collective Dynamics in Biology
Ultrafast Spectroscopy and Biological Reporters
Exploiting Anaerobes for Biomass Breakdown and Sustainable Chemistry
Current Capabilities and Limitations in Plant Imaging
Measurement and Sensing Needs for Microbial Communities
5 EDUCATION, TRAINING, AND WORKFORCE NEEDS
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