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Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
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8

Looking Ahead

Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×

This final chapter highlights overall messages, directions for potential future work, and key considerations associated with in vitro gametogenesis (IVG) and assisted reproductive technologies (ARTs) more broadly that were discussed by participants.

Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×

POTENTIAL FUTURE DIRECTIONS AND ACTIVITIES

Participants then had a conversation, led by Clark, about potential future directions and activities revolving around reproductive health and ART, which included engaging international stakeholders in conversations (Ogbogu), addressing disparities in equity and accessibility of fertility care grounded in reproductive justice (Amato, Mathews), engaging the public around ART (Mathews, Marsh), and discussing federal funding for embryonic research (Taylor, Suter).

Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×

Marsh and Clark noted the importance of developing health literacy in members of the public, particularly on reproductive health. Developing reproductive health literacy could serve as a platform to help the public interpret ART developments, including IVG, and feel more empowered to participate in conversations about their development, uses, implications, and limits. Marsh noted that educational materials ought to be developed in multiple languages and for people with differing levels of education. Clark suggested that one form of outreach could be science museum exhibits on gametogenesis, embryology, and ART.

Clark noted that future discussions could also include nonreproductive uses of IVG, such as how it could be used for research to improve human health, which was outside the scope of the workshop. Such conversations would need to be approached with care given the differing views about whether even nonheritable uses ought to be advanced, Cattapan noted, because “the legitimation of IVG for nonheritable purposes might end up being one pathway to clinical use.”

WORKSHOP WRAP-UP

Presentations and discussions over the course of the 3-day workshop brought together scientists, clinicians, sociologists, psychologists, ethicists, lawyers, patient advocates, and others. Eli Y. Adashi (Brown University) thanked speakers and participants and noted that this diverse group came together to discuss scientific, ethical, social, and legal issues for a technology not yet practiced. He expressed the hope that these discussions may lay the groundwork for future, global conversations on IVG, which has multiple potential uses and could change the landscape of fertility care across the world.

Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×

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Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Page 111
Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Page 112
Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Page 113
Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Page 114
Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Page 115
Suggested Citation:"8 Looking Ahead." National Academies of Sciences, Engineering, and Medicine. 2023. In Vitro–Derived Human Gametes as a Reproductive Technology: Scientific, Ethical, and Regulatory Implications: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27259.
×
Page 116
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Current assisted reproductive technologies such as in vitro fertilization (IVF) do not enable all prospective parents to have genetically related children. The National Academies Board on Health Sciences Policy hosted a workshop in April 2023 to explore the development of in vitro-derived human eggs and sperm from pluripotent stem cells through a process known as in vitro gametogenesis (IVG). Speakers emphasized the impacts of the potential biotechnology on research and reproductive medicine should clinical IVG ever be approved, along with the many social, ethical, legal, and technical considerations its development raises. This proceedings document summarizes workshop discussions.

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