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Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
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C

Workshop Agenda

Day 1: Mechanisms Underlying Infection-Associated Chronic Illnesses

8:30–8:45 a.m. Welcome remarks, workshop overview, and goals
Welcome
Peter Daszak, EcoHealth Alliance
Chair, Forum on Microbial Threats
John Krystal, Yale University
Cochair, Forum on Neuroscience and Nervous System Disorders
Introduction and workshop overview
Tim Coetzee, National Multiple Sclerosis Society
Workshop Cochair
Sponsor perspectives
Lyle Petersen, U.S. Centers for Disease Control and Prevention
Ben Nemser, Steven & Alexandra Cohen Foundation
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
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8:45–10:00 a.m. Session 1: Introduction to infection-associated chronic illnesses
Moderator: Rafael Obregon, UNICEF
Keynote
Tim Henrich, University of California, San Francisco
Introduction and a historical perspective
Anthony Komaroff, Harvard Medical School; Brigham and Women’s Hospital
Stakeholder perspectives
Joseph Breen, National Institutes of Health (NIH) RECOVER
Harlan Krumholz, Yale School of Medicine
Hannah Davis, Patient-Led Research Collaborative
Meghan O’Rourke, Yale University
Author of The Invisible Kingdom: Reimagining Chronic Illness
Q&A
10:00–10:15 a.m. BREAK
10:15 a.m.–12:00 p.m. Session 2: Common mechanistic factors of infection-associated chronic illnesses
Host-mediated factors (part 1)
Moderator: Peter Rowe, Johns Hopkins University
Immune Dysfunction
Post-COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Evidence for a role of autoantibodies and endothelial dysfunction and development of targeted therapies
Carmen Scheibenbogen, Charité University
Viral reactivation
Michael Peluso, University of California, San Francisco
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Autonomic Dysfunction
Overview of orthostatic intolerance: Risk factors and treatments
Satish Raj, University of Calgary
Common underlying mechanisms of chronic illness: Lessons from postural orthostatic tachycardia syndrome (POTS), ME/CFS, and long COVID
Mitchell Miglis, Stanford University
Q&A
12:00–1:00 p.m. LUNCH
1:00 pm–3:00 p.m. Session 3: Common mechanistic factors of infection-associated chronic illnesses
Host mediated factors (part 2)
Moderator: Brian Fallon, Columbia University
Effect of inflammation on the brain: Significance for chronic illnesses
Andrew Miller, Emory University
Role of the microbiome in ME/CFS
Julia Oh, The Jackson Laboratory
Pathogen-mediated factors and pathogen persistence
Viral persistence and development of chronic illness: Lessons from Epstein-Barr virus (EBV)
Bill Robinson, Stanford University
Pathogen distribution and persistence: Learnings from SARS-CoV-2
Dan Chertow, NIH
Modeling pathogen persistence: Lessons from animal studies
Monica Embers, Tulane University
Q&A
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
3:00–3:15 p.m. BREAK
3:15–4:45 p.m. Session 4: Future opportunities and research priorities in diagnostics
Moderator: Avindra Nath, National Institute of Neurological Disorders and Stroke (NINDS), NIH
Biomarkers for Lyme disease and posttreatment Lyme
John Aucott, Johns Hopkins University
Biomarkers for EBV and associations with multiple sclerosis (MS)
Alberto Ascherio, Harvard T.H. Chan School of Public Health
Microclots as a common indicator of chronic disease
Resia Pretorius, Stellenbosch University
Next-generation and metagenomic sequencing
Charles Chiu, University of California, San Francisco
Q&A
4:45–5:00 p.m. Synthesis and adjourn
Amy Proal, PolyBio Research Foundation

END OF DAY 1

Day 2: Clinical Advancements and Collaboration

8:30–9:00 a.m. Welcome remarks, review of day 1
Welcome and introduction
Tim Endy, Coalition for Epidemic Preparedness Innovations (CEPI)
Workshop Cochair
Keynote
Hilary Marston
Chief Medical Officer, U.S. Food and Drug Administration
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Q&A
9:00–10:15 a.m. Session 5: Patient-driven research panel
Moderator: Liz Horn, Lyme Disease Biobank
Panel:
Lisa McCorkell, Patient-Led Research Collaborative
Oved Amitay, Solve ME/CFS
Lorraine Johnson, MyLymeData
Liz Horn, Lyme Disease Biobank
Q&A
10:15–10:30 a.m. BREAK
10:30 a.m.–12:00 p.m. Session 6: Research innovation and required infrastructures
Moderator: Tim Endy, CEPI
Diagnostic journeys of long COVID patients
Linda Geng, Stanford University
Ultrasensitive diagnostic assays: Examples with SARS-CoV-2 and long COVID
David Walt, Harvard University
Translating infection-associated chronic illnesses research into the clinic in drug repurposing
Steven Deeks, University of California, San Francisco
Treatment approaches to posttreatment Lyme disease and a new clinical trials network
Brian Fallon, Columbia University
Q&A
12:00–1:00 p.m. LUNCH
1:00–2:45 p.m. Session 7: Future opportunities and research priorities in therapeutics
Moderator: Tim Coetzee, National Multiple Sclerosis Society
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Development of oral antiviral for COVID-19
Ravi Shankar Singh, Pfizer
Development of antivirals and combination therapies for infection-associated chronic illnesses
Sara Cherry, University of Pennsylvania
Clinical trials for multisystem inflammatory syndrome in children (MIS-C) and long COVID
Alessio Fasano, Harvard University
Long Lyme: Opportunities for prevention and treatment
Kim Lewis, Northeastern University
Clinical care for patients of various infection-associated chronic illnesses
David Putrino, Mount Sinai Health System
Q&A
2:45–3:50 p.m. Session 8: Developing a shared research agenda: Challenges and opportunities
Moderators:
Avindra Nath, NINDS, NIH
Amy Proal, PolyBio Research Foundation
Lorraine Johnson, MyLymeData
Peter Rowe, Johns Hopkins University
Q&A
3:50–4:00 p.m. Synthesis and close
Tim Endy, CEPI
Tim Coetzee, National Multiple Sclerosis Society
Workshop Cochairs

END OF WORKSHOP

Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Page 99
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Page 100
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Page 101
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Page 102
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Page 103
Suggested Citation:"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press. doi: 10.17226/27462.
×
Page 104
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 Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop
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The National Academies Forum on Microbial Threats and Forum on Neuroscience and Nervous System Disorders hosted a hybrid public workshop in June 2023 to explore opportunities to advance research and treatment of infection-associated chronic illnesses. The illnesses discussed in this workshop, including COVID-19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), persistent or posttreatment Lyme disease syndrome (PTLDS), and multiple sclerosis (MS), share overlapping mechanisms and symptoms and have been inadequately researched. Recognizing these commonalities, speakers identified the need to advance research more comprehensively, translating to improved diagnostic and treatment options for patients across multiple conditions.

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