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Suggested Citation:"Appendix B: Literature Search Strategies." National Academies of Sciences, Engineering, and Medicine. 2024. Long-Term Health Effects of COVID-19: Disability and Function Following SARS-CoV-2 Infection. Washington, DC: The National Academies Press. doi: 10.17226/27756.
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Page 229
Suggested Citation:"Appendix B: Literature Search Strategies." National Academies of Sciences, Engineering, and Medicine. 2024. Long-Term Health Effects of COVID-19: Disability and Function Following SARS-CoV-2 Infection. Washington, DC: The National Academies Press. doi: 10.17226/27756.
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Page 230
Suggested Citation:"Appendix B: Literature Search Strategies." National Academies of Sciences, Engineering, and Medicine. 2024. Long-Term Health Effects of COVID-19: Disability and Function Following SARS-CoV-2 Infection. Washington, DC: The National Academies Press. doi: 10.17226/27756.
×
Page 231
Suggested Citation:"Appendix B: Literature Search Strategies." National Academies of Sciences, Engineering, and Medicine. 2024. Long-Term Health Effects of COVID-19: Disability and Function Following SARS-CoV-2 Infection. Washington, DC: The National Academies Press. doi: 10.17226/27756.
×
Page 232
Suggested Citation:"Appendix B: Literature Search Strategies." National Academies of Sciences, Engineering, and Medicine. 2024. Long-Term Health Effects of COVID-19: Disability and Function Following SARS-CoV-2 Infection. Washington, DC: The National Academies Press. doi: 10.17226/27756.
×
Page 233
Suggested Citation:"Appendix B: Literature Search Strategies." National Academies of Sciences, Engineering, and Medicine. 2024. Long-Term Health Effects of COVID-19: Disability and Function Following SARS-CoV-2 Infection. Washington, DC: The National Academies Press. doi: 10.17226/27756.
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Page 234

Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.

Appendix B Literature Search Strategies Long-Term Health Effects Stemming from COVID-19 and Implications for the Social Security Administration—Function Literature Search Date of Search: 6/12/2023 Request: Functional changes due to Long COVID Search Parameters: Date: 2020—Present Geographic Focus: All Language: English Databases: PubMed, Embase (Ovid) and Scopus Article Type: Prospective cohort studies. If not many, include cross-sectional studies Database Searches: PubMed (“Post-Acute COVID-19 Syndrome”[Mesh] or Post-Acute-COVID-19- Syndrome[tiab] or Post-Acute-COVID-19-Syndromes[tiab] or Long-Haul- COVID-19[tiab] or COVID-19-Long-Haul[tiab] or Long-Haul-COVID-19[tiab] or Post-Acute-COVID-19-Syndrome[tiab] or Long-COVID[tiab] or Post-Acute- Sequelae-of-SARS-CoV-2-Infection[tiab] or Post-Acute-Sequelae-of-SARS- CoV-2-Infection[tiab] or Post-COVID-Conditions[tiab] or Post-COVID- Conditions[tiab] or Post-COVID-Condition[tiab] or Long-Haul-COVID[tiab] or COVID-Long-Haul[tiab] or Long-Haul-COVID[tiab] or long-covid[tiab] 229 PREPUBLICATION COPY—Uncorrected Proofs A02506-Long-Term_Health_Effects_of_COVID-19_AppB.indd 229 5/21/24 11:31 AM

230 LONG-TERM HEALTH EFFECTS OF COVID-19 or pediatric-long-covid[tiab] or pediatric-PASC[tiab] or COVID-19/ complications[Mesh]) AND (Employment[Mesh] or Unemployment[Mesh] or Quality of Life[Mesh] or “Functional Status”[Mesh] or “Disability Evaluation”[Mesh] or “International Classification of Functioning, Disability and Health”[Mesh] or “Return to Work”[Mesh] or “Return to School”[Mesh] or “Occupational Health”[Mesh] or functional[tiab] or employment[tiab] or unemployment[tiab] or life quality[tiab] or “quality of life”[tiab] or return to work[tiab] or return to school[tiab] or trajectory recovery[tiab]) AND (“Prospective Studies”[Mesh] or prospective study[tiab] or prospective studies[tiab] or prospective cohort[tiab] or “Cross-Sectional Studies”[Mesh] or cross-sectional[tiab]) Language: English Results: 262 results Embase (Ovid) Embase <1980 to 2023 Week 23> 1 *coronavirus disease 2019/co [Complication] 314 2 long covid/ or (Post-Acute-COVID-19-Syndrome or COVID-19- 6377 Syndrome-Post-Acute or Post-Acute-COVID-19-Syndromes or Long- Haul-COVID-19 or COVID-19-Long-Haul or Long-Haul-COVID-19 or Post-Acute-COVID-19-Syndrome or Post-Acute-COVID-19-Syndrome or Long-COVID or Post-Acute-Sequelae-of-SARS-CoV-2-Infection or Post-Acute-Sequelae-of-SARS-CoV-2-Infection or Post-COVID- Conditions or Post-COVID-Conditions or Post-COVID-Condition or Long-Haul-COVID or COVID-Long-Haul or Long-Haul-COVID or long-covid or chronic-COVID-syndrome or chronic-COVID-19 or COVID-long-hauler or COVID-19-long-hauler or long-haul-COVID or long-hauler-COVID or post-COVID-19-fatigue or post-COVID-19- neurological-syndrome or post-COVID-19-syndrome or post-COVID- fatigue or post-COVID-impairment or post-COVID-syndrome or post-acute-COVID-syndrome or post-acute-COVID-19 or post-acute- COVID-19-fatigue or post-acute-COVID-19-neurological-syndrome or pediatric-long-covid or pediatric-PASC or long-covid-in-children or ((late-sequelae or long-term-sequelae) adj4 covid)).ti,ab,kw. 3 1 or 2 6685 4 exp employment/ or exp unemployment/ or exp functional status/ or 3011277 exp functional assessment/ or exp disability assessment/ or exp return to work/ or exp return to school/ or exp “quality of life”/ or exp occupational health/ or (employment or unemployment or functional or disability-assessment* or disability-evaluation* or return-to-school or return-to-work or life-quality or quality-of-life or occupational-health or trajectory-recovery).ti,ab,kw. 5 3 and 4 1422 PREPUBLICATION COPY—Uncorrected Proofs A02506-Long-Term_Health_Effects_of_COVID-19_AppB.indd 230 5/21/24 11:31 AM

APPENDIX B 231 6 exp prospective study/ or (prospective-stud* or prospective cohort). 1014974 ti,ab,kw. 7 5 and 6 201 8 limit 7 to english language 196 9 exp cross-sectional study/ or cross-sectional.ti,ab,kw. 805834 10 5 and 9 162 11 limit 10 to english language 161 Scopus: TITLE-ABS-KEY((Post-Acute-COVID-19-Syndrome or COVID-19-Syndrome- Post-Acute or Post-Acute-COVID-19-Syndromes or Long-Haul- COVID-19 or COVID-19-Long-Haul or Long-Haul-COVID-19 or Post-Acute-COVID-19-Syndrome or Post-Acute-COVID-19-Syndrome or Long-COVID or Post-Acute-Sequelae-of-SARS-CoV-2-Infection or Post- Acute-Sequelae-of-SARS-CoV-2-Infection or Post-COVID-Conditions or Post-COVID-Conditions or Post-COVID-Condition or Long-Haul- COVID or COVID-Long-Haul or Long-Haul-COVID or long-covid or chronic-COVID-syndrome or chronic-COVID-19 or COVID-long-hauler or COVID-19-long-hauler or long-haul-COVID or long-hauler-COVID or post-COVID-19-fatigue or post-COVID-19-neurological-syndrome or post- COVID-19-syndrome or post-COVID-fatigue or post-COVID-impairment or post-COVID-syndrome or post-acute-COVID-syndrome or post-acute- COVID-19 or post-acute-COVID-19-fatigue or post-acute-COVID-19-­ neurological-syndrome or pediatric-long-covid or pediatric-PASC or long-covid-in-children) AND (employment or unemployment or functional or disability-assessment* or disability-evaluation* or return-to-school or return-to-work or life-quality or quality-of-life or occupational-health or trajectory-recovery) AND (cross-section* or prospective-stud* or prospective-cohort*)) Language: English Results: 274 6/13/23—Title Screening 196 papers included Inclusion and Exclusion Criteria: • Inclusion: 0 prospective cohort 0 exposure: covid PREPUBLICATION COPY—Uncorrected Proofs A02506-Long-Term_Health_Effects_of_COVID-19_AppB.indd 231 5/21/24 11:31 AM

232 LONG-TERM HEALTH EFFECTS OF COVID-19 0 outcomes: function, disability, quality of life 0 follow-up: 6 months 1 0 population: children and working-age adults • Exclusion: 0 ICU outcomes with short-term followup 0 pharmaceutical safety and treatment efficacy 0 elderly/geriatric population 0 in-hospital complications • Included as potentially relevant: 0 ICU/intubation/ventilation outcomes with 61 month followup 0 Shorter followup but relevant functional outcomes 0 Long covid in patients with specific conditions 0 Changes in function after rehab 6/20/23—Final Papers Included in Report Divided into Categories After Abstract Screening: Children: 7 Hospital: 57 ICU: 13 Non-hospital: 51 Rehab: 14 Long-Term Health Effects Stemming from COVID-19 and Implications for the Social Security Administration—Health Effects Literature Search Date of search: June 14, 2023 Search Parameters: Date: 2020—Present Geographic Focus: All Language: English Databases: PubMed, Embase (Ovid) and Scopus Article Type: Exclude case studies—focus on large cohort studies Database Searches: PubMed (“Post-Acute COVID-19 Syndrome”[Mesh] or Post-Acute-COVID-19- Syndrome[tiab] or Post-Acute-COVID-19-Syndromes[tiab] or Long-Haul- COVID-19[tiab] or COVID-19-Long-Haul[tiab] or Long-Haul-COVID-19 [tiab] or Post-Acute-COVID-19-Syndrome[tiab] or Long-COVID[tiab] or Post-Acute-Sequelae-of-SARS-CoV-2-Infection[tiab] or Post-Acute-Sequelae- PREPUBLICATION COPY—Uncorrected Proofs A02506-Long-Term_Health_Effects_of_COVID-19_AppB.indd 232 5/21/24 11:31 AM

APPENDIX B 233 of-SARS-CoV-2-Infection[tiab] or Post-COVID-Conditions[tiab] or Post- COVID-Conditions[tiab] or Post-COVID-Condition[tiab] or Long-Haul- COVID[tiab] or COVID-Long-Haul[tiab] or Long-Haul-COVID[tiab] or long-covid[tiab] or pediatric-long-covid[tiab] or pediatric-PASC[tiab] or COVID-19/complications[Mesh]) AND (symptom*[tiab] or outcome*[tiab] or clinical-feature*[tiab]) AND (persist*[tiab] or clinical-sequelae[tiab] or evolution[tiab]) AND (“Cohort Studies”[Mesh] or cohort*[tiab] or ret- rospective stud*[tiab] or multicenter stud*[tiab]) NOT “Case Reports” [Publication Type] Language: English Results: 556 Embase (Ovid) Embase {1980 to 2023 Week 23} 1 *coronavirus disease 2019/co [Complication] 314 2 long covid/ or (Post-Acute-COVID-19-Syndrome or COVID-19- 6377 Syndrome-Post-Acute or Post-Acute-COVID-19-Syndromes or Long- Haul-COVID-19 or COVID-19-Long-Haul or Long-Haul-COVID-19 or Post-Acute-COVID-19-Syndrome or Post-Acute-COVID-19-Syndrome or Long-COVID or Post-Acute-Sequelae-of-SARS-CoV-2-Infection or Post-Acute-Sequelae-of-SARS-CoV-2-Infection or Post-COVID- Conditions or Post-COVID-Conditions or Post-COVID-Condition or Long-Haul-COVID or COVID-Long-Haul or Long-Haul-COVID or long-covid or chronic-COVID-syndrome or chronic-COVID-19 or COVID-long-hauler or COVID-19-long-hauler or long-haul-COVID or long-hauler-COVID or post-COVID-19-fatigue or post-COVID-19- neurological-syndrome or post-COVID-19-syndrome or post-COVID- fatigue or post-COVID-impairment or post-COVID-syndrome or post-acute-COVID-syndrome or post-acute-COVID-19 or post-acute- COVID-19-fatigue or post-acute-COVID-19-neurological-syndrome or pediatric-long-covid or pediatric-PASC or long-covid-in-children or ((late-sequelae or long-term-sequelae) adj4 covid)).ti,ab,kw. 3 1 or 2 6685 4 (symptom* or outcome* or clinical-feature* or condition*).ti,ab,kw. 7813432 5 (persist* or clinical-sequelae or evolution).ti,ab,kw. 1230131 6 exp cohort analysis/ or cohort*.ti,ab,kw. 1678149 7 exp case study/ 99189 8 3 and 4 and 5 and 6 495 9 8 not 7 491 10 limit 9 to english language 489 PREPUBLICATION COPY—Uncorrected Proofs A02506-Long-Term_Health_Effects_of_COVID-19_AppB.indd 233 5/21/24 11:31 AM

234 LONG-TERM HEALTH EFFECTS OF COVID-19 Scopus: TITLE-ABS-KEY((Post-Acute-COVID-19-Syndrome or COVID-19-Syndrome- Post-Acute or Post-Acute-COVID-19-Syndromes or Long-Haul-COVID-19 or COVID-19-Long-Haul or Long-Haul-COVID-19 or Post-Acute-COVID-19- Syndrome or Post-Acute-COVID-19-Syndrome or Long-COVID or Post-Acute- Sequelae-of-SARS-CoV-2-Infection or Post-Acute-Sequelae-of-SARS-CoV-2- Infection or Post-COVID-Conditions or Post-COVID-Conditions or Post- COVID-Condition or Long-Haul-COVID or COVID-Long-Haul or Long-Haul- COVID or long-covid or chronic-COVID-syndrome or chronic-COVID-19 or COVID-long-hauler or COVID-19-long-hauler or long-haul-COVID or long- hauler-COVID or post-COVID-19-fatigue or post-COVID-19-neurological- syndrome or post-COVID-19-syndrome or post-COVID-fatigue or post-COVID- impairment or post-COVID-syndrome or post-acute-COVID-syndrome or post-acute-COVID-19 or post-acute-COVID-19-fatigue or post-acute- COVID-19-neurological-syndrome or pediatric-long-covid or pediatric-PASC or long-covid-in-children) AND (symptom* or outcome* or clinical-feature* or condition*) AND (persist* or evolution or clinical-sequelae) AND (cohort*)) Language: English Results: 358 PREPUBLICATION COPY—Uncorrected Proofs A02506-Long-Term_Health_Effects_of_COVID-19_AppB.indd 234 5/21/24 11:31 AM

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Since the onset of the coronavirus disease 2019 (COVID-19) pandemic in early 2020, many individuals infected with the virus that causes COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have continued to experience lingering symptoms for months or even years following infection. Some symptoms can affect a person's ability to work or attend school for an extended period of time. Consequently, in 2022, the Social Security Administration requested that the National Academies convene a committee of relevant experts to investigate and provide an overview of the current status of diagnosis, treatment, and prognosis of long-term health effects related to Long COVID. This report presents the committee conclusions.

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