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Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
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Page 197
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
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Page 198
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
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Page 199
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
×
Page 200
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
×
Page 201
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
×
Page 202
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
×
Page 203
Suggested Citation:"Appendix A: Public Meeting Agendas." National Academies of Sciences, Engineering, and Medicine. 2025. Aligning Investments in Therapeutic Development with Therapeutic Need: Closing the Gap. Washington, DC: The National Academies Press. doi: 10.17226/29157.
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Page 204

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A Public Meeting Agendas COMMITTEE ON STRATEGIES TO BETTER ALIGN INVESTMENTS IN INNOVATIONS FOR THERAPEUTIC DEVELOPMENT WITH DISEASE BURDEN AND UNMET NEEDS MARCH 18, 2024 VIRTUAL CLOSED SESSION 12:00–2:00 Closed Session—Bias and Conflict of Interest Discussion 2:00 Adjourn APRIL 26, 2024 VIRTUAL CLOSED SESSION 12:00–2:00 Closed Session—Bias and Conflict of Interest Discussion OPEN SESSION 2:00–2:05 Welcome Study Sponsors and Introductory Remarks Ellen MacKenzie and Don Berwick, Committee Cochairs 2:05–2:35 Sponsor Presentations Relevant to the Committee’s Task Goutham Kandru, Gates Ventures Hannah Menelas, Peterson Center on Healthcare Mairin Mancino, Peterson Center on Healthcare 197

198 ALIGNING INVESTMENTS IN THERAPEUTIC DEVELOPMENT 2:35–3:00 Discussion and Q&A with Sponsors Ellen MacKenzie and Don Berwick, Committee Cochairs CLOSED SESSION 3:00–5:00 Closed Session 5:00 Closing Comments Ellen MacKenzie and Don Berwick, Committee Cochairs Adjourn JUNE 17, 2024 The Keck Center, 500 Fifth Street, NW Washington, DC 20001 Room 201 CLOSED SESSION 8:30–7:30 Closed Session JUNE 18, 2024 The Keck Center, 500 Fifth Street, NW Washington, DC 20001 Room 206 CLOSED SESSION 8:30–11:00 Closed Session OPEN SESSION 11:00–12:30 Panel on Decision Making for Therapeutic Innovation Investment CLOSED SESSION 12:30–1:00 Closed Session 1:00 Adjourn JULY 23, 2024 VIRTUAL CLOSED SESSION 12:00–2:00 Closed Session

APPENDIX A 199 OPEN SESSION 2:00–3:10 Guest Speaker: Peter Kolchinsky, Managing Partner and Founder, RA Capital Q&A Session with Committee Members Moderator: David Scheer, Committee Member 3:10–3:15 Break 3:15–4:25 Guest Speaker: Aaron Kesselheim, Professor of Medicine, Harvard Medical School; Faculty Member, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital; Physician, Phyllis Jen Center for Primary Care, Brigham and Women’s Hospital Q & A Session with Committee Members Moderator: Holly Fernandez Lynch, Committee Member 4:25–4:30 Break CLOSED SESSION 4:30-5:00 Closed Session 5:00 Adjourn JULY 24, 2024 VIRTUAL CLOSED SESSION 12:00–2:30 Closed Session OPEN SESSION 2:30–3:30 Guest Speaker: Jamie Robinson, Professor of Health Economics and Director of the Berkeley Center for Health Technology, University of California, Berkeley Q&A Session with Committee Members Moderator: Scott Howell, Committee Member 3:30–3:45 Break CLOSED SESSION 3:45–5:00 Closed Session 5:00 Adjourn

200 ALIGNING INVESTMENTS IN THERAPEUTIC DEVELOPMENT SEPTEMBER 30, 2024 The Keck Center, 500 Fifth Street, NW Washington, DC 20001 Room 105 CLOSED SESSION 8:30–1:00 Closed Session OPEN SESSION 1:00 Welcome and Introduction to the Study Ellen MacKenzie, Committee Cochair 1:05 Presentation Reshma Ramachandran, Yale School of Medicine Discussion 1:25 Inma Hernandez, NAM Fellow and Moderator 2:10 Closing Remarks 2:30–5:15 Closed Session 5:15 Adjourn OCTOBER 1, 2024 The Keck Center, 500 Fifth Street, NW Washington, DC 20001 Room 105 CLOSED SESSION 8:30–1:00 Closed Session OPEN SESSION 1:00–1:05 Welcome and Introduction to the Study Don Berwick, Committee Co-Chair 1:05–1:25 Presentation  Patrizia Cavazzoni, Center for Drug Evaluation and Research, U.S. Food and Drug Administration 1:25–1:55 Discussion Stacey Adam, Committee Member and Moderator 1:55–2:00 Closing Remarks CLOSED SESSION 2:00–3:00 Closed Session 3:00 Adjourn

APPENDIX A 201 NOVEMBER 21, 2024 VIRTUAL CLOSED SESSION 12:00–1:00 Closed Session OPEN SESSION 1:00–2:00 Guest Speaker: Rob Califf, Commissioner, Food and Drug Administration Q&A Session with Committee Members Moderator: Don Berwick, Committee Cochair 2:00–2:15 Break CLOSED SESSION 2:15–5:00 Closed Session 5:00 Adjourn NOVEMBER 22, 2024 VIRTUAL CLOSED SESSION 12:00–2:00 Closed Session OPEN SESSION 2:00–3:15 Guest Speaker: Monica Bertagnolli, Director, National Institutes of Health Q&A Session with Committee Members Moderator: Ellen MacKenzie, Committee Cochair CLOSED SESSION 3:15–5:00 Closed Session 5:00 Adjourn

202 ALIGNING INVESTMENTS IN THERAPEUTIC DEVELOPMENT DECEMBER 16, 2024 2101 Constitution Avenue Washington, DC 20418 National Academy of Sciences Members Room CLOSED SESSION 9:00–1:00 Closed Session OPEN SESSION 1:00–2:15 Virtual Panel—Patient Engagement in Therapeutic Development  Pamela Gavin, Chief Executive Officer, National ­Organization for Rare Diseases  Yasmin Ibrahim, Public Health Program Director, Hepatitis B Foundation Marc Boutin, Global Head of Patient Engagement, Novartis Q&A Session with Committee Members Moderator: Joshua Salomon, Committee Member CLOSED SESSION 2:15–5:00 Closed Session DECEMBER 17, 2024 2101 Constitution Avenue Washington, DC 20418 National Academy of Sciences Members Room CLOSED SESSION 8:00–1:00 Closed Session FEBRUARY 3, 2025 The Keck Center, 500 Fifth Street, NW Washington, DC 20001 Room 105 CLOSED SESSION 9:00–5:00 Closed Session

APPENDIX A 203 FEBRUARY 4, 2025 The Keck Center, 500 Fifth Street, NW Washington, DC 20001 Room 105 CLOSED SESSION 8:30–1:00 Closed Session

Next: Appendix B: Committee and Staff Biographical Sketches »
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The United States is a global leader in biomedical research, generating therapeutic breakthroughs that advance the health of the nation and the world. The public and private sectors contribute to this advancement by funding biomedical research and development. The current level of investment in pharmaceutical development in the United States, while substantial, does not always yield desired health outcomes or meet the needs of patients. Public and private funders face a myriad of challenges that affect their funding decisions and hinder the ability of the drug development system to prioritize disease burden and unmet need - often leaving critical gaps in available treatment options.

To better understand these gaps, Gates Ventures and the Peterson Center on Healthcare asked the National Academies to examine current challenges and offer strategies and recommendations for improvement. The resulting report emphasizes that current research prioritization does not systematically account for disease burden and unmet needs, and describes how a robust, timely, accessible data system is needed. It also explores the ways in which implementing recommended policy changes could deliver better health outcomes.

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