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Vaccine Safety Forum: Summaries of Two Workshops (1997)

Chapter:EXECUTIVE SUMMARY

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Suggested Citation:"EXECUTIVE SUMMARY." Institute of Medicine. 1997. Vaccine Safety Forum: Summaries of Two Workshops. Washington, DC: The National Academies Press. doi: 10.17226/5881.
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Research to Identify Risks for Adverse Events Following Vaccination: Biological Mechanisms and Possible Means of Prevention

Cynthia J. Howe, Richard B. Johnston, and E. Russell Alexander, Editors

EXECUTIVE SUMMARY

On April 1, 1996, the Vaccine Safety Forum convened a workshop entitled Research to Identify Risks for Adverse Events Following Vaccination: Mechanisms and Possible Means of Prevention. The workshop discussed the various immunologic and genetic factors that might influence individuals' responses to vaccines, current research aimed at assessing what populations are at increased risk for experiencing adverse events from vaccines, and research avenues that could be pursued in this regard. This document represents a summary of that workshop.

As discussed at the workshop, a number of immunologic and genetic variables are likely to foster diverse responses to vaccines. Certain populations may be more susceptible to adverse events following vaccination because of some of these variables.

Studies aimed at assessing which groups of individuals may be at most risk for experiencing adverse events from specific vaccines were also addressed. These studies include those that examine the potential link between the following: arthritis and rubella vaccine; anaphylaxis and the measles, mumps, and rubella vaccine; convulsions and the diphtheria and tetanus toxoids and pertussis vaccine (DPT); high-titer measles vaccines and mortality; multiple sclerosis or Guillain-Barré syndrome and vaccination; multiple-antigen vaccinations and adverse events; and adverse events following vaccinations among premature infants.

Suggested Citation:"EXECUTIVE SUMMARY." Institute of Medicine. 1997. Vaccine Safety Forum: Summaries of Two Workshops. Washington, DC: The National Academies Press. doi: 10.17226/5881.
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On November 6, 1995, the Institute of Medicine's Vaccine Safety Forum convened a workshop on detecting and responding to adverse events following vaccination. Workshop speakers and participants discussed the difficulties in detecting adverse events, current adverse events detection and response methods and procedures, suggestions for improving the means of detecting and responding to adverse events following vaccination, and future areas of research. This document represents a summary of that workshop.

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