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Suggested Citation:"Summary of Presentations." National Research Council. 1999. Microbial and Phenotypic Definition of Rats and Mice: Proceedings of the 1998 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9617.
Page 88
Suggested Citation:"Summary of Presentations." National Research Council. 1999. Microbial and Phenotypic Definition of Rats and Mice: Proceedings of the 1998 US/Japan Conference. Washington, DC: The National Academies Press. doi: 10.17226/9617.
Page 89

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Summary of Presentations Steven P. Pakes Professor and Chairman Division of Comparative Medicine University of Texas Southwestern Medical Center Dallas, Texas CURRENT STATUS OF LABORATORY ANIMAL SCIENCE We all know that there have been significant advances in the various genomic projects. The number of genetically engineered animals is increasing exponen- tially, as other speakers have said. There has been a virtual explosion of these animals’ development, not only to study gene function but also to serve as animal models for human disease. Then there is the important element of harmonization, also mentioned earlier, and especially the standardization of inbred and outbred stocks for biomedical research, drug development, and testing. With regard to mice, there has been an attempt to talk about strain standardization, the preserva- tion of these important strains, and, certainly, genetic and microbiological moni- toring and standardizations of these important animal stocks. REVITALIZATION OF ORIGINAL FOCUS The primary purpose of the first cooperative agreement between the United States and Japan was to focus on laboratory animal quality and to exchange knowledge on technologies for identifying the presence or absence of pathogens of animals (primarily laboratory rodents) and methodologies to genetically define those animals. During the last few years, programs to address animal models and genetic preservation of important animal stocks have been conducted. This US/ Japan interaction has tried to remain true to its original aim of focusing on the quality of laboratory animals and their definition, and I believe that today’s meeting has served to revitalize that notion. 90

STEVEN P. PAKES 91 Issues related to laboratory animal quality are more important today than ever before because of the necessity, as the speakers have said, of focusing on the issues emanating from the explosion of genetically engineered stocks. Issues of microbiological quality become even more important because the presence of pathogens may significantly complicate phenotypic expression and may misrep- resent those research data. Other factors that further illuminate the importance of microbiological and genetic definition are the global exchange of animals from country to country and laboratory to laboratory and the need to compare testing results for new pharmaceutical products between countries and even between sites in different countries within the same company. FUTURE COOPERATION Our current cooperative agreement should continue to be a forum to identify major issues and concerns that deal with the expanding need and importance of defined laboratory animals for biomedical research, drug development, and test- ing and to work toward agreed-upon approaches to defining and monitoring those animals. The issues that come out of this cooperative program hopefully will stimulate other bodies to address the same topics in more detail than is possible for us in one day, once a year. I am referring primarily to the NIH and its constituents, the CIEA as well as funding agencies and pharmaceutical compa- nies in Japan, funding agencies and pharmaceutical companies in the United States, ILAR, ICLAS, and other national and international groups.

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US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.

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