National Academies Press: OpenBook

(NAS Colloquium) The Neurobiology of Pain (1999)

Chapter: Front Matter

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

COLLOQUIUM ON NEUROBIOLOGY OF PAIN

NATIONAL ACADEMY OF SCIENCES
WASHINGTON, D.C. 1999

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

NATIONAL ACADEMY OF SCIENCES

Colloquium Series

In 1991, the National Academy of Sciences inaugurated a series of scientific colloquia, five or six of which are scheduled each year under the guidance of the NAS Council’s Committee on Scientific Programs. Each colloquium addresses a scientific topic of broad and topical interest, cutting across two or more of the traditional disciplines. Typically two days long, colloquia are international in scope and bring together leading scientists in the field. Papers from colloquia are published in the Proceedings of the National Academy of Sciences (PNAS).

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

National Academy of Sciences Colloquium Arnold and Mabel Beckman Center, Irvine

The Neurobiology of Pain

December 11–13, 1998

PROGRAM

Friday, December 11, 1998

Introduction

Ronald Dubner, Colloquium Organizer

Session I: Channels

Chair and Discussion Leader John Hunter, Department of Analgesia, Roche Bioscience

Stephen G. Waxman, Department of Neurology, Yale University School of Medicine

Sodium Channels and the Pathophysiology of Pain

Michael Gold, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School

TTX-R INaand Inflammatory Hyperalgesia

Daniel Weinreich, Department of Pharmacology and Experimental Therapeutics, University of Maryland, School of Medicine

Which Potassium Channels Keep Vagal Afferent Neurons Mellow?

Discussant Peter McNaughton, Department of Physiology, King’s College London

Heat-Activated Ion Currents in Nociceptors–Transduction and Sensitization

Session II: Receptors

Chair and Discussion Leader Patrick Mantyh, Department of Preventive Sciences, School of Dentistry, University of Minnesota

Amy B. MacDermott, Department of Physiology and Cellular Biophysics and Center for Neurobiology and Behavior, Columbia University

AMPA and Kainate Receptor Expression by DRG Neurons in Culture

Edwin W. McCleskey, Vollum Institute, Oregon Health Sciences University

The Role of Sensory Modality-Selective Gene Transcription in Opioid Analgesia

Michael W. Salter, Programmes in Brain and Behavior and Cell Biology, Hospital for Sick Children, and Department of Physiology, University of Toronto

NMDA Receptors and Src in Synaptic Plasticity

Discussant Edward R. Perl, Department of Physiology, University of North Carolina School of Medicine, Chapel Hill

Receptor Expression and Regulation as Mechanisms Underlying Pain and Pain Pathology

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

Saturday, December 12, 1998

Introduction

Michael Gold, Colloquium Organizer

Tribute to John Liebeskind

Gregory Terman, Department of Anesthesiology, University of Washington, Seattle

Session III A: Systems and Imaging

Chair and Discussion Leader Donna Hammond, Anesthesia and Critical Care, University of Chicago

William D. Willis, Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas

Evidence for a Visceral Pain Pathway in the Dorsal Column of the Spinal Cord

Tony L. Yaksh, Anesthesiology Research Laboratory, University of California

The Spinal Biology in Humans and Animals of Pain States Generated by Persistent Small Afferent Input

Discussant Gerald Gebhart, Department of Pharmacology, University of Iowa

Session III B: Systems and Imaging

Chair and Discussion Leader James Campbell, Department of Neurology, Johns Hopkins University Medical School

Howard Fields, University of California, San Francisco

Neuropeptides and Brainstem Pain Modulating Circuits

Kenneth L. Casey, Neurological Service, Veterans Administration Medical Center, Ann Arbor, Michigan

Forebrain Mechanisms of Nociception and Pain: Analysis through Imaging

Discussant M. Catherine Bushnell, McGill University, Montreal

What Are the Essential Cerebral Components?

Session IV: Growth Factors and Cytokines

Chair and Discussion Leader Kenneth Hargreaves, Department of Endodontics, University of Texas Health Sciences Center

William Snider, Department of Neurology, Washington University Medical Center

Trophic Factor Regulation of Nociceptor Development

Lorne M. Mendell, Department of Neurobiology and Behavior, State University of New York at Stony Brook

Neurotrophins and Pain

Linda R. Watkins, Department of Psychology, University of Colorado at Boulder

Immune-to-Brain Communication: Implications for Sickness and Pain

Discussant Stephen B. McMahon, Neuroscience Research Centre, King’s College London

Multiple Trophic Factor Influences on Nociceptive System

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

Saturday, December 12, 1998

Session V: Development and Plasticity

Chair and Discussion Leader Ronald Dubner, Department of Oral and Craniofacial Biological Sciences, University of Maryland Dental School

Maria Fitzgerald, Department of Anatomy and Developmental Biology, University College London

Postnatal Changes in Dorsal Horn Cell Activity–The Development of Spinal Sensory Processing

Clifford J. Woolf, Department of Anesthesia and Critical Care, Massachusetts General Hospital and Harvard Medical School

Signal- and Activity-Dependent Plasticity in the Somatosensory System–Unraveling the Cellular and Molecular Mechanisms of Pain

David J. Mayer, Department of Anesthesiology, Medical College of Virginia

Cellular Mechanisms of Hyperalgesia and Morphine Tolerance and Their Interactions

Discussant Gary Bennett, Department of Neurology, Allegheny University, Philadelphia

The Revolution in Pain Research

Banquet for Colloquium Attendees

Banquet Speaker John Loeser, Department of Neurological Surgery and Anesthesiology, University of Washington Medical Center

Sunday, December 13, 1998

Session VI: Molecular Genetics

Chair and Discussion Leader Charles Inturrisi, Department of Pharmacology, Cornell University Medical College

Allan Basbaum, Department of Anatomy, University of California, San Francisco

The Neurochemistry of Acute and Persistent Pain

Michael A. Moskowitz, Department of Neurosurgery and Neurology, Massachusetts General Hospital

Migraine Pathophysiology and Treatment Mechanisms

Jeffrey Mogil, Department of Psychology, University of Illinois at Urbana

The Genetics of Pain and Pain Inhibition: From Mice to Molecules

George Uhl, National Institute on Drug Abuse, National Institutes of Health

The Mu Opiate Receptor as a Model Gene for Individual Differences in Pain and Pain Modulation

Discussant Frank Porreca, Department of Pharmacology, University of Arizona Health Sciences Center

Antisense Oligodeoxynucleotides against the TTX-Resistant Sodium Channel, PN3, Prevent and Reverse Chronic, Inflammatory and Neuropathic Pain in the Rat

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×
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Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

List of Attendees

Lisa Aimone

George S. Aitken, Delta Medical Dental Centre

David J. Anderson, California Institute of Technology

David Andrew, Barrow Neurological Institute

K. Roger Aoki, Allergan

Dietrich Arndts, Boehringer Ingelheim

Ronald K. Ashley

Laura Audell

Victor Babenko, Aalborg University

Leif K. Bakland, Loma Linda University School of Dentistry

Allan Basbaum, University of California, San Francisco

Gary Bennett, MCP Hahnemann University

Jack M. Berger, University of Southern California School of Medicine

Scott Bowersox, Elan Pharmaceuticals

Walter Bowles, University of Minnesota

Robert Brennan, University of California, Los Angeles

Cathy Bushnell, McGill University

James Campbell, John Hopkins University

Yuqing Cao, University of California, San Francisco

Ken Casey, University of Michigan

Lin Chang, University of California, Los Angeles

Jenny Chen, University of California, Los Angeles

Zhou-Feng Chen, California Institute of Technology

Ken Chow, Allergan

Glenn Clark, University of California, Los Angeles

Patricia Claude, University of Texas, Health Science Center at San Antonio

Amy D. Clegg

Joseph R. Cohen, University of California, Los Angeles

Sean P. Cook, Oregon Health Sciences University-Vollum Institute, L-474

Santosh Coutinho, University of California, Los Angeles

Marie Csete, California Institute of Technology

Minglei Cui, Allergan

Bennet Davis

Xinzhong Dong, California Institute of Technology

Emma Dormand, California Institute of Technology

Ronald Dubner, University of Maryland Dental School

Helena Ennes, University of California, Los Angeles

Mark Erlander, RW Johnson Pharmalogical Research Institute

Stephen EspitiaJack L. Feldman, University of California,

Los Angeles

Howard Fields, University of California, San Francisco

Maria Fitzgerald, University College London

Christopher M. Flores, University of Texas

Nicholas Fuller, Cedars-Sinai Medical Center-The Pain Center

Gerald Gebhart, University of Iowa

Daniel W. Gil, Allergan, Inc.

Michael Gold, University of Maryland Dental School

Jay A. Goldstein

Robert Grimm

Paul Haerich, Loma Linda University

Aldric Hama

Donna Hammond, University of Chicago

Michael Hans

Kenneth Hargreaves, University of Texas, Health Science Center at San Antonio

Michael Hayward, Oregon Health Sciences University

Standiford Helm

David Helton, B. Braun Medical Inc.

Michael A. Henry, University of Colorado Health Science Center

H. Haydon Hill, Rehabilitation Medicine Associates

Dianne Hodges, CoCensys, Inc.

Lynda C. Honour

John Hunter, Roche

Victor Ilyin, CoCensys, Inc

Charles Inturrisi, Cornell University

Douglass L. Jackson, University of Washington-School of Dentistry

Stephen W. Jenkins, Allergan, Inc.

Russell Johnson, University of California, Los Angeles

Gerald J. Jonak, Dupont

Wade Kingery, Veterans Adminstration

Cheryl Kitt, National Institutes of Health

Beat Knusel, Allergan, Inc

Brad Kolls

Chris Konkoy

Lawrence Kruger, University of California, Los Angeles Medical Center

Nancy Lan, CoCensys Inc.

Letitia Lau

Jacqueline E. Lee, University of Colorado, Boulder

Julia Liebeskind

Wei-Jen Lin, Allergan

John Loeser

Page viii Cite
Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

Lin Luo, RW Johnson Pharmalogical Research Institute

Z. David Luo, University of California, San Diego

Kabirullah Lutfy, University of California, Los Angeles

Amy MacDermott, Columbia University

Nigel T. Maidment, University of California, Los Angeles

Celine Maillot, West Los Angeles V.A. Medical Center

Phil Malan, The University of Arizona

Mario G. Maldonado

Annika Malmberg, University of California, San Francisco

Corinne Manetto, Cedars-Sinai Comprehensive Cancer Center

Patrick Mantyh, University of Minnesota

Jianren Mao, VCU

Wendy Martin, Glaxo Wellcome, Inc.

William J. Martin, University of California, San Francisco

Juan Carlos Marvizon, University of California, Los Angeles

Emeran A. Mayer, University of California, Los Angeles, Division of Digestive Diseases

Ed McCleskey, Oregon Health Sciences University

Steve McMahon, King’s College London

Peter McNaughton, King’s College London

Lorne Mendell, State University of New York, Sunny Brook

Robert L. Merrill, University of California, Los Angeles School of Dentistry

Somsak Mitrirattanakul, University of California, Los Angeles

Jeffrey Mogil, University of Illinois at Urbana Champaign

Derek Molliver, Washington University of Saint Louis

Carlo V. Morpurgo

Mike Moskowitz, Harvard University

Million Mulugeta, West Los Angeles V.A. Medical Center

Alexander Nemirovsky

John K. Neubert

Alan Newman

Michael Ossipov, University of Arizona

A. Pace-Floridia

Pamela Pierce Palmer, University of California, San Francisco

Ed Perl, University of North Carolina

Karla Petersen, University of California, San Francisco

Frank Porreca, University of Arizona

Joshua P. Prager, California Pain Medical Center

Robert W. Presley, Pain Care Specialists

Steven Graff Radford, University of California, Los Angeles

John L. Reeves II, University of California, Los Angeles

Ke Ren, University of Maryland

Linda J. Rever

Steven Richeimer, University of California, Davis

Ruth Riley, University of California, San Francisco

Susan Roche, Orofacial Pain Management Clinic

Gary G. Rosengarten, The Pain Center, CSMC

Mike Salter, University of Toronto

Christine Sang

Harry Sernaker, University of Maryland

Seth Silbert, Oregon Health Sciences University-Vollum Inst.

William Snider, Washington University

Michael C. Son

Linda S. Sorkin, University of California, San Diego

Athena Spanoyannis, Allergan Inc.

Igor Spigelman, University of California, Los Angeles, School of Dentistry

Yvette Tache, University of California, Los Angeles

Brad Taylor, University of California, San Francisco

Edgar Tenorio, Elan Pharmaceuticals

Gregory Terman

Arnold Towe, University of Washington

Jodie Trafton, University of California, San Francisco

George Uhl, National Institute of Health

Clayton Varga, PRI

Douglas R. Wall

Wendy M. Walwyn, University of California

John Y.-X. Wang, Elan Pharmaceuticals

Yu Hua Wang, University of California, Los Angeles

Linda Watkins, University of Colorado

Steve Waxman, Yale University

Jen Yu Wei, University of California, Los Angeles, School of Medicine

Daniel Weinreich, University of Maryland

Ursula Wesselman, Johns Hopkins University

Larry A. Wheeler, Allergan

Joan Wilentz, National Institute of Dental and Cranofacial Research

William Willis, University of Texas Medical Branch

Steven P. Wilson, University of South Carolina School of Medicine

Richard Woodward, Cocensys Inc.

Clifford Woolf, Harvard University

Tony Yaksh, University of California, San Diego

Jen Yu, University of California, Irvine Medical Center

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×

P ROCEEDINGS OF THE N ATIONAL A CADEMY OF S CIENCES OF THE U NITED S TATES OF A MERICA

Table of Contents

Papers from a National Academy of Sciences Colloquium on The Neurobiology of Pain

 

 

The neurobiology of pain
Ronald Dubner and Michael Gold

 

7627–7630

 

 

John C. Liebeskind (1935–1997): A tribute
Gregory W. Terman

 

7631–7634

 

 

Sodium channels and pain
S. G. Waxman, S. Dib-Hajj, T. R. Cummins, and J. A. Black

 

7635–7639

 

 

A comparison of the potential role of the tetrodotoxin-insensitive sodium channels, PN3/SNS and NaN/SNS2, in rat models of chronic pain
Frank Porreca, Josephine Lai, Di Bian, Sandra Wegert, Michael H. Ossipov, Richard M. Eglen, Laura Kassotakis, Sanja Novakovic, Douglas K. Rabert, Lakshmi Sangameswaran, and John C. Hunter

 

7640–7644

 

 

Tetrodotoxin-resistant Na+ currents and inflammatory hyperalgesia
Michael S. Gold

 

7645–7649

 

 

Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons
Ruth Cordoba-Rodriguez, Kimberly A. Moore, Joseph P. Y. Kao, and Daniel Weinreich

 

7650–7657

 

 

Ion channels gated by heat
P. Cesare, A. Moriondo, V. Vellani, and P. A. McNaughton

 

7658–7663

 

 

Causalgia, pathological pain, and adrenergic receptors
Edward R. Perl

 

7664–7667

 

 

Forebrain mechanisms of nociception and pain: Analysis through imaging
Kenneth L. Casey

 

7668–7674

 

 

A visceral pain pathway in the dorsal column of the spinal cord
William D. Willis, Elie D. Al-Chaer, Michael J. Quast, and Karin N. Westlund

 

7675–7679

 

 

The spinal biology in humans and animals of pain states generated by persistent small afferent input
Tony L. Yaksh, Xiao-Ying Hua, Iveta Kalcheva, Natsuko Nozaki-Taguchi, and Martin Marsala

 

7680–7686

 

 

Supraspinal contributions to hyperalgesia
M. O. Urban and G. F. Gebhart

 

7687–7692

 

 

Neurotrophins and hyperalgesia
X.-Q. Shu and L. M. Mendell

 

7693–7696

 

 

Src, a molecular switch governing gain control of synaptic transmission mediated by N-methyl-D-aspartate receptors
Xian-Min Yu and Michael W. Salter

 

7697–7704

Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
×
Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
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Suggested Citation:"Front Matter." National Academy of Sciences. 1999. (NAS Colloquium) The Neurobiology of Pain. Washington, DC: The National Academies Press. doi: 10.17226/9630.
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