Closing Evidence Gaps in Clinical Prevention

An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine was convened to evaluate evidence gaps described by the United States Preventive Services Taskforce (USPSTF) and other clinical practice guideline developers and to create a taxonomy of evidence gaps for their use in future recommendations and I statements.

The workflow below outlines the steps users can take when using the clinical prevention research taxonomy to identify evidence gaps and develop a research agenda. Users go through three main steps:

  • 1. Yellow box
    Instructs users to review the evidence base regarding whichever clinical prevention topic they are considering.
  • 2. Blue boxes
    Directs users to the three evidence gap facets of the taxonomy. Having reviewed the evidence, users should now be able to use the three facets to systematically identify evidence gaps from the literature base. Users may use one or any combination of the taxonomies according to their own interests.
  • 3. Green box
    This step has two sequential components: users will first use the prioritization criteria facet to set priorities across evidence gaps within a specific topic. Then they will use the study specifications facet to outline the research needs for addressing those evidence gaps.


Review Evidence CLICK AN AREA BELOW TO LEARN MORE Use a systematic review of evidence about the preventive service to develop a recommendation statement. Gather additional information if needed from stakeholders. Characterize Evidence Gaps Using Relevant Taxonomies Develop a Research Agenda Foundational Issues Taxonomy Analytic Framework Taxonomy Dissemination and Implementation Taxonomy Set priorities across all evidence gaps using the prioritization criteria. Outline study specifications to address each high-priority gap.

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Closing Evidence Gaps in Clinical Prevention (2021)