Research in Radiotherapy Approaches to Chemical Sensitization (1961) / Chapter Skim
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f r ‘ \ ' " ' Natron +\ " yO ee \ f . \ a a | ok "5 Ly Q ae ° a Nuclear Science Series Report Number 35 _Research in Radiotherapy Approaches to Chemical Sensitization Proceedings of an Informal Conference Carmel, California, May 6-8, 1960 Robert F
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Library of Congress Catalog Card Number: 54-60815
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PREFACE This volume was prepared from the transcript of an informal con- ference held at Carmel, California, May 6-8, 1960. These Proceedings constitute the sixth of a series, following chronologically after National Academy of Sciences-National Research Council Publications 305, 367, 450, 513, and 571.
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and stimulating the discussions. The chairmen were: Henry I
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ACKNOWLEDGMENTS AND INTRODUCTORY REMARKS HENRY S KAPLAN: I would like to welcome all of you here to Carmel and to this Conference.
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HENRY S KAPLAN: I will call now on Dr.
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CONTENTS Preface.
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19. Plans for Unified Staging and Cooperative Reporting of Certain Types of Neoplastic Disease Gilbert H
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To discover the various reactions and interactions in stages 1 and 2 is obviously a difficult task. For the most part, we cannot follow them as they occur, so that it has been necessary to study them indirectly: from the observation of what occurs at the end of stage 2 the investigator endeavors to infer what must have happened previously.
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It is readily appreciated that a model involving a fixed number of targets, sensitive only to direct hits, from which recovery does not occur, would be relatively easy to deal with. On the other hand, if in- direct hits can occur, the analysis becomes more complex.
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distribution. The spread of this curve on the abscissa may be regarded as an index of biologic variation rather than a parameter of the mode of action of x-rays.
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the probability of killing any organism is exactly the same. The dose to hit all targets once (on the average)
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The slope of the final linear part of the curve is equal to 1/Do. From the slope, then, we find that D, = 96 r.
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taking into account the primary and secondary radiation absorption pro- cesses, the physical and chemical interactions that immediately follow, and the fine structure of the living cell -- is one that cannot be ignored. Lea's monograph (5)
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KOHN: No. I merely meant that other complications between the target and the observers supervened to distort the form of the curve so that the targets were no longer apparent.
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BAGSHAW: This curve does not indicate lack of contamination. Even the ones that survive are automatically beyond it.
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2. Time-Dose Factors in the Irradiation of Mammalian Cells IN VITRO Mortimer M
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