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Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc (2001) / Chapter Skim
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15 A Research Agenda
Pages 580-586

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From page 580...
... APPROACH The following approach resulted in the research agenda iclentified in this chapter: 1. Identify gaps in knowledge to unclerstanci the role of the nutrients in human health, functional and biochemical indicators to assess nutrient requirements, methodological problems related to the assessment of intake of these micronutrients and to the assessment of acloquacy of intake, relationships of nutrient intake to chronic disease, and adverse effects of nutrients; 2.
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From page 581...
... An indicator of nutrient status is neecleci for which a cutoff point has been iclentifieci, below which nutrient status is clocumenteci to be impaired. (In the case of manganese, serum manganese concentrations appear to be sensitive to large variations in manganese intake; however, there is a lack of information to indicate that this indicator reflects manganese status.)
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From page 582...
... Several assumptions that cannot be tested experimentally are often neecleci, and the numbers obtained for body pool sizes are inherently imprecise. Even if accurate assessments of body pools were possible and were obtained, such information would be useful in setting a requirement only if one could establish the body pool size at which functional deficiency occurs.
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From page 583...
... Therefore, further research is neecleci to evaluate the metabolic role of these five trace minerals in human health. Methodo;logy For some micronutrients, serious limitations exist in the methods available to analyze laboratory values indicative of micronutrient status or to determine the micronutrient content of foocis, or both.
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From page 584...
... Thus, information on which to base a UL is extremely limited for some micronutrients. THE RESEARCH AGENDA Five major types of information gaps were noted: (1)
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From page 585...
... and Canaclian nutritional surveys. Because of a lack of sufficient ciata, a Tolerable Upper Intake Level (UL)
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Key Terms

  • food components
  • preformed vitamin
  • body mass
  • trace minerals
  • upper intake

  • chronic diseases
  • body pool
  • intake level
  • estimated average
  • average requirements

  • tolerable upper
  • body pools
  • clinical endpoints
  • biochemical indicators
  • intermediate endpoints

  • clinical consequence
  • serum manganese
  • balance studies
  • micronutrient status
  • research paradigms

  • increasing evidence
  • analyze laboratory
  • composition tables
  • positive control
  • identify gaps

  • impaired status
  • necessarily equivalent
  • chronic disease
  • average requirement
  • include underreporting


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