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Appendix E: Drugs Used in the Treatment of MS
Pages 387-400

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From page 387...
... Appendix E Dams Used ~ me Deemed ~ AS ~ 0~ go/
From page 390...
... and Europe As above Total lymphoid irradiation Off label use in the U.S. and Europe As above Paclitaxel Phase II Clinical Trials As above 2-Chlorodeoxyadenosine Phase III Clinical Trials As above Mitoxantrone Phase III Clinical Trials As above IMMUNOMODULATION Therapeutic Medication Status as Putative Mechanisms Strategy Options of 1999 Of Action 1)
From page 391...
... and Europe Phase II Phase I 5) Alter the balance Antibodies to TNFa, Phase I/II of pro-inflammatory IL- 1 (Thl)
From page 392...
... Eliprodil Pirfenidone Testing discontinued; phase III trial revealed an increase in heart attacks associated with this drug Phase I Preclinical testing Phase I Blocks Thl differentiation and effecter function, inhibits IFNg production Inhibits TNF production Prevent neuronal death Prevent neuronal death Prevents gliosis, blocks TNF synthesis continued
From page 393...
... and Europe, remyelination Phase III Oli go den droc yte grafts Preclinical testing Promote remyelination Eliprodil Preclinical testing Promote remyelination
From page 394...
... 394 APPENDIX E o to to to Cut o z o 2 A o to o En o z o C)
From page 395...
... APPENDIX E 395 so ca 0 ~ ca ~ ~ 'd t,.4 ~ 'd ~ .` Cd ~ Cd V Cd V o m~ V~= ~ ~ ° j =' ~ 2 0 ~ ~ ~ == ~ i ' ~ 2 Y ~ 2 =, ~ c == a O ~ ~ ~ i, ~ hi, ~ O a == 2 0 ° y e ~ °5 O ° 3 ~ 2 0 e == ~ ~ ~ ~ c a ° u e 0 ~ e ~ ~ ~ ~ 2 2 2 ° ~ = ~~ ~ c · ' ~ 3 ~ ~ c ~ ~ ~ ~ ~ o ~ O O ~ C ~ ˘ ~ ~ ~ o ~ R o ~ ~ ~ ~ ~ C 00 ~ X m ~0 4o O ~ TIC ~ O O is, ~ ·g ˘ ~ C ~ ~ an, ~ C V ~ ~ ~ ~ ~ ~ .~ ~ ca ~ ~ O O O ~ ~ ~ Z ~
From page 396...
... 396 z o o to to Cal En o z o > z o to o En In a a z a APPENDIX E C)
From page 397...
... APPENDIX E 397 ~ ~ ~ so ca ca 0 ,= ~ ~ ~ .
From page 398...
... 398 APPENDIX E z ~ 3 ~ ~ ~ Q ° ~ ~ ~ o ~ ~ ca c)
From page 400...
... 400 APPENDIX E Drugs Usecl to Treat Various Symptoms: Overview Bladder Control Capsaicin Desmopressin Detrol Dicyclomine hydrochloride Hyoscyamine .


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