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(NAS Colloquium) Virulence and Defense in Host--Pathogen Interactions Common Features Between Plants and Animals (2001) / Chapter Skim
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Molecular and Cell Biology Aspects of Plague
Pages 27-32

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From page 27...
... This Yop virulon allows extracellular Yersinia docked at the surface of a host cell to inject specialized proteins, called Yops, across the plasma membrane. The injected Yops disturb the dynamics of the cytoskeleton and block the production of pro-inflammatory cytokines, thereby favoring the survival of the invading Yersinia.
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From page 28...
... In contrast with YopB, YopD, and LcrV, LcrG is not a released protein, but its exact localization in the bacterium remains elusive. It is required for efficient translocation of Yersinia Yop effecter proteins into the eukaryotic cells but it is not required for pore formation.
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From page 29...
... Both SycE and SycH are required for efficient translocation of their partner Yops into eukaryotic cells (35~. However, when YopE is delivered by a Yersinia polymutant strain that synthesizes an intact secretion and translocation apparatus but no other effecter than YopE, it appears that YopE is delivered even in the absence of its chaperone and chaperone-binding site (70~.
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From page 30...
... . Studies using HeLa cells have shown that YopH dephosphorylates p130CaS, paxillin, and the focal adhesion kinase (FAK)
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From page 31...
... Through the analysis of various mutants, YopH appeared to be the main effector involved in these events. Thus YopH not only contributes to the evasion of the innate immune response but it could also incapacitate the host adaptive immune response.
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From page 32...
... 59. Schesser, K., Spiik, A.-K., Dukuzumuremyi, J.-M., Neurath, M
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Key Terms

  • eukaryotic cells
  • plasma membrane
  • iii secretion
  • yop virulon
  • eukaryotic cell

  • focal adhesion
  • yop effectors
  • secretion signal
  • hela cells
  • unpublished results

  • ysc apparatus
  • ysc secretion
  • called yops
  • extracellular yersinia
  • secretion channel

  • translocators yopb
  • secretion apparatus
  • phosphotyrosine phosphatase
  • ysc proteins
  • outer membrane

  • target cell
  • hybrid proteins
  • yoph dephosphorylates
  • immune response
  • inner membrane

  • proteins called
  • translocation apparatus
  • adenylate cyclase
  • syc chaperones
  • adhesion proteins


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