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(NAS Colloquium) Virulence and Defense in Host--Pathogen Interactions Common Features Between Plants and Animals (2001) / Chapter Skim
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Plants and Animals Share Functionally Common Bacterial Virulence Factors
Pages 64-70

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From page 64...
... Although many bacterial virulence components are thought to be host-specific, numerous studies have demonstrated the existence of what appear to be universal virulence mechanisms used by diverse bacterial species (1~. Similarly, recent work has revealed common features underlying host defense responses against pathogens in plants, insects, and mammals (2~.
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From page 65...
... aeruginosa strains exhibit ecotype specificity is typical of plant pathogen interacFig.
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From page 66...
... Histologic sections removed from livers and kidneys 36 h postinoculation revealed massive perivascular bacterial invasion of the organs and associated tissue Table 1. Animal mortality and proliferation studies of P
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From page 67...
... GacA encodes a transcriptional activator of genes encoding extracellular products involved in pathogenicity (46~. Isogenic PA14 plcS, toxA, and gacA mutants were constructed by marker exchange, and the resulting mutants were tested for pathogenicity in the Arabidopsis leaf infiltration assay and in the burned mouse model.
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From page 68...
... What Types of Virulence Mechanisms Are Conserved Through Evolution? The "multihost" pathogenesis screens performed in our laboratories identified a variety of virulence-associated genes that encode proteins involved in transcriptional control, posttranscriptional control, efflux systems, biosynthetic enzymes involved in phenazine production, toxins, and proteins of unknown function.
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From page 69...
... Third, and perhaps most importantly, even though many pathogens cause disease in a single or limited number of host species these studies provide strong evidence that there exists several universal bacterial virillence mechnnisms hi~hiv c.onserved across phylogeny. Although some of the virulence-associated genes identified have homologues in other pathogenic bacteria, the exact role of these genes in pathogenesis remains unclear in most cases.
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From page 70...
... (1993) in Pseudomonas aeruginosa as an Opportunistic Pathogen, eds.
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Key Terms

  • virulence mechanisms
  • aeruginosa strains
  • aeruginosa strain
  • days postinfection
  • nonvertebrate hosts

  • mouse model
  • burned mouse
  • cause disease
  • mammalian pathogenesis
  • disease symptoms

  • multihost pathogenesis
  • bacterial virulence
  • arabidopsis leaves
  • elicit disease
  • aeruginosa virulence

  • plant pathogenesis
  • fast killing
  • burn model
  • previously unknown
  • homoserine lactones

  • aeruginosa mutants
  • vessel parenchyma
  • surface attachment
  • bacterial counts
  • common features

  • aeruginosa genes
  • effector molecules
  • systemic spread
  • pathogens cause
  • host species


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