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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals (2001) / Chapter Skim
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E Example of a Summary of a Technical Support Document
Pages 182-185

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 182...
... Data on acute exposures of humans to both isomers of dimethylhydrazine are limited to case reports of accidental exposures. Signs and symptoms of exposure include respiratory irritation, pulmonary edema, nausea, vomiting, end neurologic effects.
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From page 183...
... Lethality has been demonstrated when cumulative exposures exceed these levels only slightly. The available data suggest that there is a very narrow margin between exposures resulting in no significant toxicity and those causing substantial lethality (the lethal concentration for 50% of the animals (LCso)
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From page 184...
... A cancer assessment based upon the carcinogenic potential (withdrawn cancer slope factors) of dimethyThydrazine revealed that AEGL values for a theoretical excess lifetime ~ 0-4 carcinogenic risk exceeded the AEGL- 2 values that were based on noncancer endpoints.
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Key Terms

  • behavioral changes
  • toxic response
  • limited data
  • toxic effects
  • acute exposure

  • exposure guideline
  • observable effects
  • cumulative exposures
  • extreme severity
  • significant toxicity

  • muscle fasciculations
  • dogs exposed
  • narrow margin
  • interspecies variability
  • intraspecies variability

  • humans suggest
  • include respiratory
  • behavioral effects
  • muscle fasciculation
  • dogs varied

  • substantial lethality
  • near linear
  • respiratory tract
  • lethal concentration
  • following chronic

  • seen including
  • responses varied
  • assessment based
  • guideline level
  • neurologic effects


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