Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals (2001) / Chapter Skim
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F Example of the Derivation of AEGL Values Appendix in a Technical Support Document
F Example of the Derivation of AEGL Values Appendix in a Technical Support Document
Pages 186-189
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From page 186... ...
The absence of an AEGL-1 does not imply that exposure below the AEGL-2 is without adverse effects. DERIVATION OF AEGL-2 VALUES Key study: Weeks et al.
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From page 187... ...
were more susceptible to the adverse effects of dimethyThydrazine. Calculations: 360 ppm/30 = 12 ppm C'Xt=k 12ppm x 15 min= 180ppmmin Time scaling: C' x t = k (ten Berge et al.
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From page 188... ...
Uncertainty factors: An uncertainty factor of 3 for interspecies variability was applied because the toxic response to dimethyThydrazine was similar across the species tested. This was especially true for lethality responses (LCso values for varying time periods ranging from 5 min to 4 h)
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From page 189... ...
Exposureresponse data indicated a near linear concentration-response relationship (n = 0.84 for rats, n = 0.80 for dogs)
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