Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals (2001) / Chapter Skim
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1 Overview of AEGL Program and NAC/AEGL Committee
1 Overview of AEGL Program and NAC/AEGL Committee
Pages 19-33
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From page 19... ...
This voluntary program identified a list of more than 400 acutely toxic chemicals and provided this information, together with interim technical guidance, for the development of emergency response plans at the local community level. At that time, EPA adopted the National Institute for Occupational Safety and Health SLOSH)
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At a workshop hosted by EPA in ~ 987, it was proposed by EPA that the ERP Committee and scientists from federal and state agencies as well as scientists and clinicians from academia and public interest groups pool their technical and financial resources and formica single committee comprising scientists from both the public sector and the private sector to develop AEGL values. EPA conceived the idea to formulate general guidance for developing short-term exposure limits and together with the Agency for Toxic Substances and Diseases Registry (ATSDR)
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The community emergency exposure levels (CEELs) and the acute exposure guideline levels (AEGEs)
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. Each AEGL tier is distinguished by varying degrees of severity of toxic effects, as initially conceived by the ERP Committee and further defined in Guidelines for Developing Community Emergency Exposure Levels for Hazardous Substances MARC 1 993a)
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From page 23... ...
, and the use of uncertainty factors, modifying factors, interspecies and intraspecies extrapolation methods, time scaring, carcinogenic risk assessment, and other methods and procedures relevant to the development of AEGL values. COMMITTEE MEMBERSHIP AND ORGANIZATIONAL STRUCTURE The NAC/AEGL Committee comprises representatives of federal, state and local agencies and organizations in the private sector that derive programmatic or operational benefits from the AEGL values.
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SELECTION OF CHEMICALS FOR AEGL DEVELOPMENT A master list of approximately 1,000 acutely toxic chemicals was initially compiled through the integration of individual priority lists of chemicals submitted by each U.S. federal agency.
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From page 25... ...
for the development of short-term exposure limits, the comprehensive nature of data collection and evaluation, the consistency of the methodologies and procedures used to develop the values, the potential of acute toxicity testing in cases of inadequate data, and the adoption of the most comprehensive peer-review process ever used to establish shortterm exposure limits for acutely toxic chemicals. The comprehensive data-gathering process involves literature searches for all relevant published data and the mobilization of all relevant unpublished data.
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From page 26... ...
A detailed summary of the AEGL development process is presented in the next section. THE AEGL DEVELOPMENT AND PEER-REVIEW PROCESS The process that has been established for the development of the AEGL values is the most comprehensive ever used for the determination of shortterm exposure limits for acutely toxic chemicals.
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From page 27... ...
Stage 2: Proposed AEGLs Once the NAC/AEGL Committee has reached a consensus or a two-thirds majority vote on the AEGL values and supporting rationale, they are referred to as "proposed" AEGEs and are published in the Federal Register for a 30day review and comment period. Following publication, the committee reviews the public comments, addresses and resolves relevant issues, and seeks a consensus or a two-thirds majority vote of those present on the original or modified AEGL values and the accompanying scientific rationale.
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From page 28... ...
Final AEGL values may be used on a permanent basis by all federal, state and local agencies, and private organizations. It is possible that new data will become available from time to time that challenges the scientific credibility of final AEGLs.
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Reviews, comments, and revisions are continuous up to the time of the meeting, and committee members are expected to be familiar with the draft, proposed, or interim AEGLs, the supporting rationale, and other data and information in each TSD, and to participate in the resolution of residual issues at the meeting. Procedures for the AEGL Development Teams and the other committee members regarding work on proposed or interim AEGLs are similar to those for draft AEGLs.
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From page 30... ...
VALUE OF A COLLABORATIVE EFFORT IN TO AEGL PROGRAM The value of a collaborative effort in the AEGL program is related primariTy to the pooling of substantial resources of the various stakeholders and the direct or indirect involvement of a significant portion ofthe relevant scientific community from both the public and private sectors. These factors, in turn, promote greater productivity, efficiency, and cost effectiveness of such an effort and greatly enhance the scientific credibility of the AEGEs that are developed by the committee.
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From page 31... ...
This approach eliminates inconsistencies and contusion among individuals and organizations involved in emergency planning, response, and prevention of chemical accidents. In global terms, the NAC/AEGL Committee represents an approach to unifying the international community In the development and use of chemical emergency exposure limits.
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From page 32... ...
Because of the complex nature of chemical accidents, the populations at risk, the variable capabilities among emergency response units, and many other considerations related to a specific event, it is beyond the scope of this document to discuss or speculate on specific actions that should or could be taken at any point in time or at a given level of exposure to a specific chemical. However, emergency responders and planners know that various options are available, depending upon the circumstances, for reducing or even preventing the adverse impacts of chemical releases.
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From page 33... ...
OVERVIEW OFAEGL PROGRAMAND NAC/AEGL COMMITTEE Threshold Levers DEATH AEGL~ DISABLING ~-2 DISCC~IFOIU AEGL-1 DErECTABILllY FIGURE 1-1 Hazard assessment. Elects Increasing likelihood of dam 4~ rrmt~:dF~abili~to~es~4e All; -1rcreasi'ng~se~j9~: ~ irreversible or cuber serious long-lasting effects Anaease in ramble disairf~t .
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