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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals (2001) / Chapter Skim
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G Example of Time-Scaling Calculations Appendix in a Technical Support Document
Pages 190-193

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From page 190...
... has been used to relate exposure concentration and duration to a toxic effect (Rinehart and Hatch 1964~. This concept states that exposure concentration and exposure duration may be reciprocally adjusted to maintain a cumulative exposure constant (k)
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From page 191...
... Two data sets of LC50 values for different time periods of exposure were analyzed using a linear regression analysis of the Tog-log transformation of a plot of C vs t to derive values of n for dimethylhydrazine. Dimethy~hydrazine Dog Data from Weeks et al.
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From page 192...
... Log Time Concentration Time cog Concentration 5 24,500 0.6990 4.3892 15 8,230 1.1761 3.9154 60 4,010 1.4771 3.6031 240 252 2.3802 2.4014 n = 0.84
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From page 193...
... APPENDIX G 193 B - t at Concenb~tion x Time Cure 'l~3,5 \\ ~ 1 \ 3 \ 2 ~~ O.S 1 1.5 2 IS Log nme Calculated LCso values: Min Concentration 30 60 1,449.93 240 276.00 480 120.42 3,323.28
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Key Terms

  • exposure concentration
  • regression analysis
  • cumulative exposure
  • exposure constant
  • toxic effect

  • linear regression
  • effect endpoint
  • equally dependent
  • quantitatively defines
  • relationship relative

  • health effect
  • specific quantitative
  • inverse relationship
  • derived value
  • relate exposure

  • concept states
  • airborne concentration
  • analyzed using
  • specific health
  • derive values

  • progressive decrease
  • time yields
  • relationship described
  • qualitative response
  • reciprocally adjusted

  • empirically derived
  • toxic response
  • time concentration
  • ten berge
  • log time


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