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Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals (2001) / Chapter Skim
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H Example of a Carcinogenicity Assessment Appendix in a Technical Support Document
Pages 194-195

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From page 194...
... To convert to a level of monomethy~hydrazine that would cause a theoretical excess cancer risk of 10-4: Risk of 1 x 10-4 = (1 X 10-4/1) x 1 mg/m3 To convert a 70-y exposure to a 24-h exposure: 194 1 x 10~4mg/m3 (virtually safe dose)
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From page 195...
... 20.6 mg/m3 (~.5 ppm) Because the AEGL-2 values based upon acute toxicity were equivalent to or Tower than the i0-4 risk values derived based on potential carcinogenicity, the acute toxicity data were used for the AEGEs for dimethy~hydrazine.
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Key Terms

  • acute toxicity
  • carcinogenicity assessment
  • cancer risk
  • toxicity data
  • values derived

  • preliminary carcinogenicity
  • derived based
  • values based
  • inhalation slope
  • theoretical excess

  • described methodologies
  • follows previously
  • previously described
  • assessment follows
  • withdrawn inhalation

  • risk values
  • excess cancer
  • potential carcinogenicity
  • withdrawn slope
  • human inhalation

  • virtually safe
  • cancer process
  • inhalation rate
  • risk levels
  • multistage factor

  • body weight
  • safe dose
  • uncertainty regarding
  • fractional exposure


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